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Affiliation Department |
Department of Life Science and Applied Chemistry
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Title |
Associate Professor |
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External Link |
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MIZUNO Toshihisa
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Degree
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Doctor (Engineering) ( 2000.03 Kyushu University )
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Master (Engineering) ( 1997.03 Kyushu University )
Research Interests
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Biofunctional chemistry, Protein Engineering, Peptide Engineering
Research Areas
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Nanotechnology/Materials / Chemical biology
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Nanotechnology/Materials / Nanobioscience
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Nanotechnology/Materials / Structural materials and functional materials
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Nanotechnology/Materials / Polymer materials
From School
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Nagoya Institute of Technology Faculty of Engineering Graduated
- 1995.03
Country：Japan
From Graduate School
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Kyushu University Graduate School, Division of Engineering Doctor's Course Completed
1997.04 - 2000.03
Country：Japan
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Kyushu University Graduate School, Division of Engineering Master's Course Completed
1995.04 - 1997.03
External Career
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テキサス大学オースチン校博士研究員 研究員
2001.04 - 2002.03
Country：United States
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日本学術振興会 日本学術振興会特別研究員
1999.04 - 2001.03
Country：Japan
Professional Memberships
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Sigma Xi, 米国科学研究名誉協会, 正会員
2023.11
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高分子学会
2015.04
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Division of Biofunctional Chemistry
2002.04
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The Chemical Society of Japan
1995.04
Research Career
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タンパク質固定化不織布の材料開発・機能開発
The Other Research Programs
Project Year： 2010.04
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蛋白質カプセルを利用した薬剤タンパク質のDDSキャリア開発
The Other Research Programs
Project Year： 2017.04
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ジェミニ型ペプチド界面活性剤の材料開発・機能開発
(not selected)
Project Year： 2010.04
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天然樹脂からの光応答性細胞培養足場材の開発
The Other Research Programs
Project Year： 2018.04
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非リボソームペプチド合成酵素に対する研究
The Other Research Programs
Project Year： 2020.04
Papers
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Design of Cell Adhesive Shellac derivatives and endowment of photo-switchable cell-adhesion properties Reviewed
Yurino Sunakawa, Mai Kondo, Yasushi Yamamoto, Tomohiko Inomata, Yasumichi Inoue, Daisuke Mori, Toshihisa Mizuno
ACS Applied Bio Materials 2023.11
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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Construction of the lactate-sensing fibremats by confining sensor fluorescent protein of lactate inside nanofibers of the poly(HPMA/DAMA)/ADH-nylon 6 core–shell fibremat Reviewed
Yuna Kato, Shuichi Iwata, Yusuke Nasu, Akiko Obata, Kenji Nagata, Robert E. Campbell, Toshihisa Mizuno
RSC Advances 23 29584 - 29593 2023.10
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1039/D3RA06108F
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Construction and characterisation of lactase-encapsulated core–shell fibremats comprising poly(AM/DAAM)/ADH nano-fibre core and thin nylon 6 or acetyl cellulose shell Reviewed
Taira Ishiguro, Akiko Obata, Kenji Nagata, Toshihiro Kasuga, Toshihisa Mizuno
RSC Advances 22 34931 - 34940 2022.12
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1039/D2RA06620C
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Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol Reviewed International journal
Natsumi Sumito, Shuhei Koeda, Naoki Umezawa, Yasumichi Inoue, Shinya Tsukiji, Tsunehiko Higuchi, Toshihisa Mizuno
Bioconjugate Chemistry 31 ( 3 ) 821 - 833 2020.01
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Development of New Antimicrobial Agents from Cationic PG-surfactants containing oligo-Lys peptide Reviewed International journal
R. Kimura, M. Shibata, S. Koeda, A. Miyagawa, H. Yamamura, T. Mizuno
Bioconjugate Chemistry 29 ( 12 ) 2018.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Scaffolds Designing from Protein-loadable Coaxial Electrospun Fibermats of poly(acrylamide)-co-poly(diacetone acrylamide) and Gelatin Reviewed International journal
Yuji Tanikawa, Akiko Obata, Kenji Nagata, Toshihiro Kasuga, Toshihisa Mizuno
Current Applied Polymer Science 4 01 2021.07
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Design of PG-surfactants bearing polyacrylamide polymer chain to solubilize membrane proteins in a surfactant-free buffer Reviewed International journal
Taro Shimamoto, Tatsuki Nakakubo, Tomoyasu Noji, Shuhei Koeda, Keisuke Kawakami, Nobuo Kamiya, Toshihisa Mizuno
International Journal of Molecular Sciences 22 1524 2021.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Construction of Protein-loadable Protein Cages Using the Hybrid Proteins of the Oleosin Hydrophobic Domain and Hydrophilic Dimeric Coiled-coil Reviewed
Taiki Nishiyama, Kento Sugiura, Kouta Sugikawa, Atsushi Ikeda, Toshihisa Mizuno
Colloid and Interf. Sci. Commun. 40 100352 2021.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Coaxial Electrospun Fibermat of Poly(AM/DAAM)/ADH and PCL: Versatile Platform for Encapsulating Functionally Active Enzymes Reviewed International journal
Yuji Tanikawa, Yuya Ido, Ren Ando, Akiko Obata, Kenji Nagata, Toshihiro Kasuga, Toshihisa Mizuno
Bulletin of the Chemical Society of Japan 93 1155 - 1163 2020.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Synthesis and characterization of chemically-reactive solubilization surfactants for membrane proteins and preparation of membrane protein hydrogel microfibers Reviewed
Aki Taniguchi, Shuhei Koeda, Tomoyasu Noji, Keisuke Kawakami, Natsumi Sumito, Takehisa Dewa, Shigeru Itoh, Nobuo Kamiya, Toshihisa Mizuno
Colloid and Interf. Sci. Commun. 32 100199 2019.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Misc
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生理活性を保持した不織布の開発 Invited
水野稔久、小幡亜希子
( 7 ) 5 - 16 2017.07
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
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生理活性を保持した不織布の開発 Invited
水野稔久、小幡亜希子
Chemical Engineering 60 ( 12 ) 911 - 920 2015.12
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：化学工業社
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Construction of the Artificial Proteins Whose Functions Can Be Altered with the Specific External Inputs by Using the Engineered Protein Modules
Toshihisa Mizuno, Masayuki Oda, Toshiki Tanaka
NetsuSokutei 35 ( 5 ) 227 - 236 2008.10
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings) Publisher：The Japan Society of Calorimetry and Thermal Analysis
Presentations
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ラクターゼを固定化したコアシェル不織布の開発
水野 稔久、石黒 泰良、谷川 雄治、井戸 祐也
2023年 繊維学会秋季研究発表会 2023.11
Event date： 2023.11
Language：Japanese Presentation type：Oral presentation (general)
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乳酸センサータンパク質内包コアシェル不織布の機能評価と細胞培養材料への応用
加藤 柚奈、水野 稔久
2023年 繊維学会秋季研究発表会 2023.11
Event date： 2023.11
Language：Japanese Presentation type：Oral presentation (general)
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Cloning Enzyme Modules 1 and 10 in Polymyxin B Biosynthesis: Assessing Enzymatic Activities and Substrate Amino Acid Specificities International conference
Mai Nemoto, Taichi Mano, Wataru Ando, Toshihisa Mizuno
6th G’L’owing Polymer Symposium in KANTO (GPS-K 2023) 2023.11
Event date： 2023.11
Language：English Presentation type：Oral presentation (general)
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Core-shell fibermats, encapsulating ligand-binding proteins, via SCES method for isolation and concentration of target ligands International conference
Momoka Kato, Toshihisa Mizuno
6th G’L’owing Polymer Symposium in KANTO (GPS-K 2023) 2023.11
Event date： 2023.11
Language：English Presentation type：Oral presentation (general)
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Construction of the lactate-sensing fibermats by confining sensor fluorescent protein of lactate inside nanofibers of the poly(HPMA/DAMA)/ADH-nylon6 core-shell fibermat Invited International conference
T. Mizuno, Y. Kato
16th International Symposium on Nanomedicine (ISNM2023) 2023.11
Event date： 2023.11
Language：English Presentation type：Oral presentation (invited, special)
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乳酸センサータンパク質を内包したコアシェル不織布の細胞培養材料への応用
加藤 柚奈、水野 稔久
第72回高分子討論会 2023.09
Event date： 2023.09
Language：Japanese Presentation type：Poster presentation
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Polymyxin B合成酵素を構成する酵素モジュールの遺伝子クローニングと蛋白質精製手法の検討
根本 真衣、水野 稔久
第72回高分子討論会 2023.09
Event date： 2023.09
Language：Japanese Presentation type：Poster presentation
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Polymyxin合成酵素モジュールの単離精製とそこに含まれるアデニル化ドメインの活性評価
真野 太一、水野 稔久
第72回高分子討論会 2023.09
Event date： 2023.09
Language：Japanese Presentation type：Poster presentation
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クマリン修飾Shellacを用いた細胞接着性の光制御
砂川 祐莉乃、近藤 麻衣、水野 稔久
第72回高分子討論会 2023.09
Event date： 2023.09
Language：Japanese Presentation type：Poster presentation
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異なる長さのリンカーを導入したVHH抗体融合両親媒性蛋白質による蛋白質カプセルの作製とがん細胞内への導入評価
高橋 孝介、西山 泰貴、水野 稔久
第72回高分子討論会 2023.09
Event date： 2023.09
Language：Japanese Presentation type：Poster presentation
Industrial Property Rights
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リポペプチド誘導体を含む抗菌剤
木村亮介、水野稔久、山村初雄、宮川淳
Application no：2017-094745 Date applied：2017.05
Country of applicant：Domestic Country of acquisition：Domestic
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金属イオン応答性蛍光発色タンパク質
水野稔久、村尾香織、田中俊樹
Application no：2006-247008 Date applied：2006.10
Country of applicant：Domestic Country of acquisition：Domestic
Awards
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中部支部奨励賞
2022.05 第86回 生化学会中部支部 ゲスト蛋白質を内包可能な蛋白質カプセルへの抗体表面修飾と細胞内導入評価
高橋孝介、西山泰貴、水野稔久
Award type：Award from Japanese society, conference, symposium, etc.
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優秀ポスター賞
2022.05 高分子学会 タンパク質を内包可能なタンパク質カプセル設計と抗体修飾による細胞内導入評価
高橋孝介、西山泰貴、水野稔久
Award type：Award from Japanese society, conference, symposium, etc.
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第 9 回 CSJ 化学フェスタ 2019 学生ポスター賞
2019.11 公益社団法人 日本化学会
⻄山 泰貴
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
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永井学術賞
2017.03 永井科学技術財団
水野稔久
Award type：International academic award (Japan or overseas) Country：Japan
Scientific Research Funds Acquisition Results
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外来蛋白質の細胞膜透過キャリアとしてのアルキル鎖を複数含むカチオン性ペプチド開発
2020.04 - 2023.03
科学研究費補助金 基盤研究(C)
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生体高分子の3次元印刷を可能とする新規バイオインキの開発と生体材料構築への応用
2017.04 - 2020.03
科学研究費補助金 基盤研究(C)
水野稔久
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膜蛋白質の機能分子としての利用を指向した新規ゲル化手法の開発とナノ材料創成
2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Other External Funds
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ペプチドジェミニ界面活性剤ベースの蛋白質医薬品導入試薬の開発
2020.04 - 2021.03
民間財団等 高橋産業経済研究財団
Grant type：Competitive
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ペプチドジェミニ界面活性剤ベースの蛋白質医薬品導入試薬の開発
2019.04 - 2020.03
民間財団等 高橋産業経済研究財団
Grant type：Competitive
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生体高分子の３次元配列化に利用可能なバイオインキの開発
2017.04 - 2019.03
民間財団等 小笠原科学技術振興財団
Grant type：Competitive
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乳糖不耐症者を対象とした新規ラクターゼ固定化担体の開発
2017.04 - 2019.03
民間財団等 東海産業技術振興財団 一般発展型
Grant type：Competitive
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核酸アプタマー内包固定化不織布の作成と分子センサーへの応用
2016.04 - 2017.03
民間財団等 小柳財団
Grant type：Competitive
Past of Commissioned Research
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不織布型の新規酵素固定化担体の開発
Grant number：JPMJTM20EH 2020 - 2022.03
科学技術振興機構 研究成果最適展開支援プログラム(A-STEP) General Consignment Study
Authorship：Principal investigator Grant type：Competitive