|
Affiliation Department |
Department of Life Science and Applied Chemistry
|
|
Title |
Associate Professor |
|
External Link |
|
MIZUNO Toshihisa
|
|
|
Degree
-
Doctor (Engineering) ( Kyushu University )
-
Master (Engineering) ( Kyushu University )
From School
-
Nagoya Institute of Technology Faculty of Engineering Graduated
- 1995.03
Country：Japan
From Graduate School
-
Kyushu University Graduate School, Division of Engineering Master's Course Completed
1995.04 - 1997.03
-
Kyushu University Graduate School, Division of Engineering Doctor's Course Completed
1997.04 - 2000.03
Country：Japan
External Career
-
テキサス大学オースチン校博士研究員 研究員
2001.04 - 2002.03
Country：United States
-
日本学術振興会 日本学術振興会特別研究員
1999.04 - 2001.03
Country：Japan
Research Career
-
膜タンパク質可溶化試薬の開発
Grant-in-Aid for Scientific Research
Project Year： 2011.04
-
Rational design of the stimuli-respondent proteins
Grant-in-Aid for Scientific Research
Project Year： 2004.04 - 2010.03
Papers
-
Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol Reviewed International journal
Natsumi Sumito, Shuhei Koeda, Naoki Umezawa, Yasumichi Inoue, Shinya Tsukiji, Tsunehiko Higuchi, Toshihisa Mizuno
Bioconjugate Chemistry xx ( xx ) xx - xx 2020.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Development of New Antimicrobial Agents from Cationic PG-surfactants containing oligo-Lys peptide Reviewed International journal
R. Kimura, M. Shibata, S. Koeda, A. Miyagawa, H. Yamamura, T. Mizuno
Bioconjugate Chemistry 29 ( 12 ) 2018.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Construction of Enzyme-encapsulated Fibermats from the Cross-linkable Copolymers Poly(acrylamide)-co-poly(diacetone acrylamide) with the Bi-functional Cross-linker, Adipic Acid Dihydrazide Reviewed International coauthorship International journal
Yuya Ido, Anthony L. B. Maçon, Makito Iguchi, Yuto Ozeki, Shuhei Koeda, Akiko Obata, Toshihiro Kasuga, Toshihisa Mizuno
Polymer 132 342 - 352 2017.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Design of New Extraction Surfactants for Membrane Proteins from Peptide-Gemini Surfactants (PG-surfactants) International journal
M. Shibata, S. Koeda, T. Noji, K. Kawakami, Y. Ido, Y. Amano, N. Umezawa, T. Higuchi, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno
Bioconjugate Chemistry 27 ( 10 ) 2469 - 2479 2016.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Coaxial Electrospun Fibermat of Poly(AM/DAAM)/ADH and PCL: Versatile Platform for Encapsulating Functionally Active Enzymes Reviewed International journal
Yuji Tanikawa, Yuya Ido, Ren Ando, Akiko Obata, Kenji Nagata, Toshihiro Kasuga, Toshihisa Mizuno
Bulletin of the Chemical Society of Japan 93 1155 - 1163 2020.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Construction of DNAzyme-Encapsulated Fibermats Using the Precursor Network Polymer of Poly(γ-glutamate) and 4-Glycidyloxypropyl Trimethoxysilane Reviewed International journal
Koji Mizuno, Shuhei Koeda, Akiko Obata, Jun Sumaoka, Toshihiro Kasuga, Julian R. Jones, Toshihisa Mizuno
Langmuir 33 ( 16 ) 4028 - 4035 2017.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Rational Design of Novel High-Molecular-Weight Solubilization Surfactants for Membrann Proteins from the peptide gemini surfactants (PG-surfactants) Reviewed International journal
S. Koeda, T. Suzuki, T. Noji, K. Kawakami, Y. Ido, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno
Tetrahedron 72 6898 - 6908 2016.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Light-induced hydrogen production by Photosystem I–Pt nanoparticle conjugates immobilized in porous glass plate nanopores Reviewed International journal
T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa
Res. Chem. Intermed 42 ( 0 ) 7731 - 7742 2016.09
Language：English Publishing type：Research paper (scientific journal)
-
Construction and Characterization of Protein-Encapsulated Electrospun Fibermats Prepared from a Silica/Poly(γ-glutamate) Hybrid Reviewed International journal
S. Koeda, K. Ichiki, N. Iwanaga, K. Mizuno, M. Shibata, A. Obata, T. Kasuga, T. Mizuno
Langmuir 32 ( 1 ) 221 - 229 2015.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Applications of Peptide Gemini Surfactants as Solubilization Surfactants for Photosystems I and II of Cyanobacteria Reviewed
Shuhei Koeda, Katsunari Umezaki, Tomoyasu Noji, Atsushi Ikeda, Keisuke Kawakami, Masaharu Kondo, Yasushi Yamamoto, Jian-Ren Shen, Keijiro Taga, Takehisa Dewa, Mamoru Nango, Toshiki Tanaka, Toshihisa Mizuno
Langmuir 29 ( 37 ) 11667 - 11680 2013.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Misc
-
生理活性を保持した不織布の開発 Invited
水野稔久、小幡亜希子
( 7 ) 5 - 16 2017.07
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
-
生理活性を保持した不織布の開発 Invited
水野稔久、小幡亜希子
Chemical Engineering 60 ( 12 ) 911 - 920 2015.12
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media) Publisher：化学工業社
-
Construction of the Artificial Proteins Whose Functions Can Be Altered with the Specific External Inputs by Using the Engineered Protein Modules
Toshihisa Mizuno, Masayuki Oda, Toshiki Tanaka
NetsuSokutei 35 ( 5 ) 227 - 236 2008.10
Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (international conference proceedings) Publisher：The Japan Society of Calorimetry and Thermal Analysis
Presentations
-
Novel method to construct the protein-encapsulated fibermats by electrospinning and application to immobilization enzymes Invited International conference
2022.12
Event date： 2022.12
Language：English Presentation type：Oral presentation (invited, special)
-
Development and functional evaluation of core-shell fibermat with detectable lactic acid concentration International conference
Yuna Kato, Toshihisa Mizuno
2022.12
Event date： 2022.12
Language：English Presentation type：Oral presentation (general)
-
Construction of the protein capsule composed of the amphiphilic proteins, OLE-ZIP and ProG-OLE-ZIP, and evaluation of cell-type selective cytosolic delivery of the guest proteins International conference
Kousuke Takahashi, Taiki Nishiyama, Toshihisa Mizuno
2022.12
Event date： 2022.12
Language：English Presentation type：Oral presentation (general)
-
細胞膜透過PG-surfactantを用いた外来ペプチド・蛋白質の細胞内導入、細胞種選択的なキャリア開発への取り組み
山田桃果、今井豊大、解江諒平、住藤夏美、井上靖道、梅澤直樹、水野稔久
第12回CSJ化学フェスタ2022 2022.10
Event date： 2022.10
Language：Japanese Presentation type：Poster presentation
-
乳酸濃度を検出可能なコアシェル不織布の開発と機能評価
加藤柚奈、水野稔久
第12回CSJ化学フェスタ2022 2022.10
Event date： 2022.10
Language：Japanese Presentation type：Poster presentation
-
両親媒性蛋白質からなる蛋白質カプセルのDDSキャリアとしての応用
高橋孝介、西山泰貴、水野稔久
第12回CSJ化学フェスタ2022 2022.10
Event date： 2022.10
Language：Japanese Presentation type：Poster presentation
-
細胞膜透過PG-surfactantを用いた新規細胞内TGFβシグナル伝達抑制剤の開発
山田桃果、今井豊大、住藤夏美、井上靖道、梅澤直樹、水野稔久
第71回高分子討論会 2022.09
Event date： 2022.09
Language：Japanese Presentation type：Poster presentation
-
P. PolymyxaのPmxBに含まれるアデニル化ドメインの活性評価
真野太一・水野稔久
第71回高分子討論会 2022.09
Event date： 2022.09
Language：Japanese Presentation type：Poster presentation
-
1本鎖型抗体を共有結合により導入した両親媒性蛋白質の設計と蛋白質カプセルの形成能評価
高橋孝介、西山泰貴、水野稔久
第71回高分子討論会 2022.09
Event date： 2022.09
Language：Japanese Presentation type：Poster presentation
-
センサー蛋白質内包固定化コアシェル不織布の開発
加藤柚奈、水野稔久
第71回高分子討論会 2022.09
Event date： 2022.09
Language：Japanese Presentation type：Poster presentation
Industrial Property Rights
-
リポペプチド誘導体を含む抗菌剤
木村亮介、水野稔久、山村初雄、宮川淳
Application no：2017-094745 Date applied：2017.05
Country of applicant：Domestic Country of acquisition：Domestic
-
金属イオン応答性蛍光発色タンパク質
水野稔久、村尾香織、田中俊樹
Application no：2006-247008 Date applied：2006.10
Country of applicant：Domestic Country of acquisition：Domestic
Awards
-
優秀ポスター賞
2022.05 高分子学会 タンパク質を内包可能なタンパク質カプセル設計と抗体修飾による細胞内導入評価
高橋孝介、西山泰貴、水野稔久
Award type：Award from Japanese society, conference, symposium, etc.
-
中部支部奨励賞
2022.05 第86回 生化学会中部支部 ゲスト蛋白質を内包可能な蛋白質カプセルへの抗体表面修飾と細胞内導入評価
高橋孝介、西山泰貴、水野稔久
Award type：Award from Japanese society, conference, symposium, etc.
-
第 9 回 CSJ 化学フェスタ 2019 学生ポスター賞
2019.11 公益社団法人 日本化学会
⻄山 泰貴
Award type：Award from Japanese society, conference, symposium, etc. Country：Japan
-
永井学術賞
2017.03 永井科学技術財団
水野稔久
Award type：International academic award (Japan or overseas) Country：Japan
Scientific Research Funds Acquisition Results
-
外来蛋白質の細胞膜透過キャリアとしてのアルキル鎖を複数含むカチオン性ペプチド開発
2020.04 - 2023.03
科学研究費補助金 基盤研究(C)
-
生体高分子の3次元印刷を可能とする新規バイオインキの開発と生体材料構築への応用
2017.04 - 2020.03
科学研究費補助金 基盤研究(C)
水野稔久
-
膜蛋白質の機能分子としての利用を指向した新規ゲル化手法の開発とナノ材料創成
2014.04 - 2017.03
科学研究費補助金 基盤研究(C)
Other External Funds
-
ペプチドジェミニ界面活性剤ベースの蛋白質医薬品導入試薬の開発
2020.04 - 2021.03
民間財団等 高橋産業経済研究財団
Grant type：Competitive
-
ペプチドジェミニ界面活性剤ベースの蛋白質医薬品導入試薬の開発
2019.04 - 2020.03
民間財団等 高橋産業経済研究財団
Grant type：Competitive
-
生体高分子の３次元配列化に利用可能なバイオインキの開発
2017.04 - 2019.03
民間財団等 小笠原科学技術振興財団
Grant type：Competitive
-
乳糖不耐症者を対象とした新規ラクターゼ固定化担体の開発
2017.04 - 2019.03
民間財団等 東海産業技術振興財団 一般発展型
Grant type：Competitive
-
核酸アプタマー内包固定化不織布の作成と分子センサーへの応用
2016.04 - 2017.03
民間財団等 小柳財団
Grant type：Competitive
Past of Commissioned Research
-
不織布型の新規酵素固定化担体の開発
Grant number：JPMJTM20EH 2020 - 2022.03
科学技術振興機構 研究成果最適展開支援プログラム(A-STEP) General Consignment Study
Authorship：Principal investigator Grant type：Competitive