Papers - NAKAMURA Shuichi
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Amine-Ligated Boryl Radical-Enabled Hydrofunctionalization of Styrenes via Halogen-Atom Transfer of Alkyl and Aryl Bromides Invited Reviewed
Naoki Yasukawa, Naito Seiya, Koki Obata, Shuichi Nakamura
Synthesis 2024.10
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
ケトンへのアミノチオールの分子内環化反応の論文で、我々がこれまでに開発してきたイミダゾリン-リン酸触媒で高選択性の発現に初めて成功しました。
ケトン特異的な反応で四置換不斉炭素の構築に成功しました。DOI： 10.1055/a-2427-9313
Other Link： https://doi.org/10.1055/a-2427-9313
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Asymmetric Conjugate Addition of Phosphine Sulfides to α-Substituted β-Nitroacrylates Using Cinchona Alkaloid Amide Catalysts Reviewed
Kosei Miyake, Akane Iwamura, Kazuki Fujita, Tsunayoshi Takehara, Takeyuki Suzuki, Naoki Yasukawa, Shuichi Nakamura*
Organic Letters 26 ( 39 ) 8233 - 8238 2024.09
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1021/acs.orglett.4c02643
Other Link： https://pubs.acs.org/doi/10.1021/acs.orglett.4c02643
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Organocatalytic Asymmetric Synthesis of 2,3-Dihydro-4H-imidazol-4-ones via Cyclocondensations of N-Silyl Iminoesters Reviewed
Kazuki Ogura, Shota Ando, Tsunayoshi Takehara, Takeyuki Suzuki, Shuichi Nakamura*
ACS Catalysis 14 ( 18 ) 13792 - 13799 2024.09
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
Other Link： https://pubs.acs.org/doi/10.1021/acscatal.4c04230
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Enantioselective Addition of Thiols to Acyclic Ketiminoesters Using Cinchona Alkaloid Amide/Zinc(II) Catalysts Reviewed
Yuka Iizuka, Koki Obata, Tsunayoshi Takehara, Takeyuki Suzuki, Shuichi Nakamura
Advanced Synthesis & Catalysis 2024.08
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
ケトンへのアミノチオールの分子内環化反応の論文で、我々がこれまでに開発してきたイミダゾリン-リン酸触媒で高選択性の発現に初めて成功しました。
ケトン特異的な反応で四置換不斉炭素の構築に成功しました。Other Link： https://onlinelibrary.wiley.com/doi/10.1002/adsc.202400674
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Photoredox-Catalyzed 1,4-Peroxidation−Sulfonylation of Enynones: A Three-Component Radical Coupling Approach for the Synthesis of Highly Functionalized Allenes Reviewed
Divya Bhatt, Kosei Miyake, Shuichi; Nakamura, Hum Young Kim, Kyungsoo Oh
Organic Letters 26 ( 15 ) 2955 - 2959 2024.04
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1021/acs.orglett.4c00517
Other Link： https://pubs.acs.org/doi/10.1021/acs.orglett.4c00517
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Catalytic Enantioselective Construction of an α-Thio-Substituted α-Aminonitriles-Bearing Tetrasubstituted Carbon Center Reviewed
Yusuke Oyamada, Miku Fujii, Tsunayoshi Takehara, Takeyuki Suzuki, Shuichi Nakamura*
ACS Catalysis 14 ( 5 ) 3411 - 3419 2024.02
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
Other Link： https://pubs.acs.org/doi/10.1021/acscatal.3c05757
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Organocatalytic Stereoselective Decarboxylative Addition of α-Amido Malonic Acid Half Oxyesters to Isatins Reviewed
Kazuki Fujita, Ibuki Kumazawa, Jyunpei Yokoi, Kazuki Abe, Tsunayoshi Takehara, Takeyuki Suzuki, Naoki Yasukawa, Shuichi Nakamura
Advanced Synthesis & Catalysis 366 ( 3 ) 438 - 443 2024.01
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
ケトンへのアミノチオールの分子内環化反応の論文で、我々がこれまでに開発してきたイミダゾリン-リン酸触媒で高選択性の発現に初めて成功しました。
ケトン特異的な反応で四置換不斉炭素の構築に成功しました。Other Link： https://onlinelibrary.wiley.com/doi/110.1002/adsc.202301100
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Accessing unnatural α-amino acids with tetrasubstituted stereogenic centers via catalytic enantioselective reactions of ketimine-type α-iminoesters/α-iminoamides Invited Reviewed
Naoki Yasukawa and Shuichi Nakamura
59 ( 54 ) 8343 - 8374 2023.06
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1039/D3CC02236F
Other Link： https://pubs.rsc.org/en/content/articlelanding/2023/CC/D3CC02236F
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Enantioselective Construction of Consecutive Tetrasubstituted Stereogenic Centers by Reaction of α-Substituted β-Nitroacrylates with Oxazol-5-(4H)-ones Catalyzed by Cinchona Alkaloid Sulfonamide Catalysts Reviewed International journal
Kazuki Fujita, Momona Hattori, Tsunayoshi Takehara, Takeyuki Suzuki, and Shuichi Nakamura*
2023.04
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1021/acs.orglett.3c00783
Other Link： https://pubs.acs.org/doi/10.1021/acs.orglett.3c00783
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Direct Catalytic Enantioselective Reaction of -Isocyanoacetonitriles with Ketimines Using Cinchona Alkaloid AmideCu(II) Catalysts Reviewed International journal
Shuichi Nakamura, Masato Kibe, Tsunayoshi Takehara, Takeyuki Suzuki
Organic Letters 25 ( 6 ) 1040 - 1044 2023.02
Authorship：Lead author, Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：ACS
αイソシアノアセトニトリルを不斉合成反応に適用した初めての不斉反応の開発に成功しました。
当研究室で開発した触媒を用いることで、合成が難しいとされる連続四置換不斉炭素の構築を行いました。
反応機構は、ＤＦＴ計算を用い、遷移状態解析・ＮＣＩ解析を行い、解明しました。DOI： 10.1021/acs.orglett.3c00259
Other Link： https://pubs.acs.org/doi/10.1021/acs.orglett.3c00259
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Enantioselective Synthesis of Benzothiazolines from Fluoroalkyl Ketones Using Chiral Imidazoline-Phosphoric Acid Catalysts Reviewed International coauthorship
Yuka Iizuka, Tatsumi Wada, Kazuki Ogura, Tsunayoshi Takehara, Takeyuki Suzuki, Shuichi Nakamura
Advanced Synthesis & Catalysis 364 ( 24 ) 4271 - 4274 2022.12
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
ケトンへのアミノチオールの分子内環化反応の論文で、我々がこれまでに開発してきたイミダゾリン-リン酸触媒で高選択性の発現に初めて成功しました。
ケトン特異的な反応で四置換不斉炭素の構築に成功しました。Other Link： https://onlinelibrary.wiley.com/doi/10.1002/adsc.202201039
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Enantioselective allenylation of ketimines derived from isatins using chiral bis(imidazoline)-palladium catalysts Reviewed International coauthorship
Yusuke Oyamada, Shintaro Yamasaki, Mika Tsuzuki, Takumi Kitagawa, Masaru Kondo, Takahiro Sasamori, Shuichi Nakamura
Advanced Synthesis & Catalysis 364 ( 24 ) 4255 - 4259 2022.11
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
ビスイミダゾリンPD触媒を用いて、ケチミンへのエナンチオ選択的なアレニル化反応に成功しました。
置換基のついたアレニル化反応例は、これまでにも報告されていましたが、単純アレニル化は初めての成功例です。
分子軌道計算を用いて、反応機構を解明しました。Other Link： https://onlinelibrary.wiley.com/doi/10.1002/adsc.202201017
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Enantioselective Reaction of N-Unprotected Activated Ketimines with Phosphine Oxides Catalyzed by Chiral Imidazoline-Phosphoric Acids Reviewed International journal
Ogura, Kazuki; Isozumi, Itsuki; Takehara, Tsunayoshi; Suzuki, Takeyuki; Nakamura, Shuichi
Organic Letters 24 ( 43 ) 8088 - 8092 2022.10
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：ACS
我々が開発をしてきたイミダゾリン-リン酸触媒を用いることで、ケトエステル類へのPictet-Spengler反応で四置換不斉炭素構築に成功しました。
鎖状ケトエステルでの初めての成功例です。 -
Enantioselective Pictet–Spengler Reaction of Acyclic α-Ketoesters Using Chiral Imidazoline-Phosphoric Acid Catalysts Reviewed International journal
Shuichi Nakamura, Yoichiro Matsuda, Tsunayoshi Takehara, Takeyuki Suzuki
Organic Letters 24 ( 4 ) 1072 - 1076 2022.01
Authorship：Lead author, Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：ACS
我々が開発をしてきたイミダゾリン-リン酸触媒を用いることで、ケトエステル類へのPictet-Spengler反応で四置換不斉炭素構築に成功しました。
鎖状ケトエステルでの初めての成功例です。DOI： 10.1021/acs.orglett.1c04316
Other Link： http://dx.doi.org/10.1021/acs.orglett.1c04316
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Asymmetric Synthesis of Cyclic Amines with Tetrasubstituted Stereocenters via Aza-Henry Reaction of Cyclic Ketimines using Cinchona Alkaloid Sulfonamide/Zinc(II) Catalysts Reviewed International journal
Naoki Yasukawa,* Ami Yamanoue, Tsunayoshi Takehara, Takeyuki Suzuki, Shuichi Nakamura*
Chemical Communications 58 ( 9 ) 1318 - 1321 2022.01
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：RCS
プロリン由来の環状イミンに我々が開発してきた不斉触媒を用いて、不斉aza-Henry反応の開発に成功しました。
反応機構は、分子軌道計算によって明らかにしています。DOI： 10.1039/D1CC06492D
Other Link： http://dx.doi.org/10.1039/D1CC06492D
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Enantioselective Reaction of N-Cyano Imines: Decarboxylative Mannich-type Reaction with Malonic Acid Half Thioesters Reviewed International journal
Yusuke Oyamada, Kazuto Inaba, Takahiro Sasamori, Shuichi Nakamura*
Chemical Communications 58 ( 13 ) 2172 - 2175 2022.01
Authorship：Last author, Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：RCS
窒素上にシアノ基を導入したイミンへのエナンチオ選択的反応はこれまでに全く報告例がありませんでしたが、
シアノ基を活性化することで高度な立体制御に成功しました。
N-シアノイミンの初めてのエナンチオ選択的反応例になります。DOI： 10.1039/D1CC07191B
Other Link： http://dx.doi.org/10.1039/D1CC07191B
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Enantiodivergent Reaction of Ketimines with Malononitriles Using Single Cinchona Alkaloid Sulfonamide Catalysts Reviewed International journal
Shuichi Nakamura, Natsuki Matsumoto, Masato Kibe, Kazuki Abe, Tsunayoshi Takehara, Takeyuki Suzuki
Advanced Synthesis & Catalysis x ( x ) x - x 2021.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley
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Enantioselective Vinylogous Mannich Reaction of Acyclic Vinylketene Silyl Acetals with Acyclic Ketimines Reviewed International journal
Kazuki Ogura, Tsunayoshi Takehara, Takeyuki Suzuki, Shuichi Nakamura*
Advanced Synthesis & Catalysis x ( x ) x - x 2021.07
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley
直鎖のケチミンと直鎖ビニルケテンシリルアセタールの反応による不斉ビニロガスMannich反応を検討しました。
ケチミンとビニルケテンシリルアセタールの両方が鎖状の例としては、初めてとなり、キラルビスイミダゾリン-Zn(II)触媒を用いることで達成しました。
分子軌道計算による反応遷移状態の解明も行いました。Other Link： http://dx.doi.org/10.1002/adsc.202100872
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Enantioselective Reaction of 2H-Azirines with Oxazol-5-(4H)-ones Catalyzed by Cinchona Alkaloid Sulfonamide Catalysts Reviewed International journal
Kazuki Fujita, Masataka Miura, Yasuhiro Funahashi, Tsubasa Hatanaka, and Shuichi Nakamura*
Organic Letters 23 ( 6 ) 2104 - 2018 2021.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：ACS
当研究室で開発した不斉触媒を用いることで、オキサゾロンの2H-アジリンへの不斉Mannich反応の開発に成功しました。
この反応により、連続四置換不斉炭素を構築することが可能となりました。
また、非常に珍しいオキサゾロンの2位に不斉反応し、ケチミンへの世界初の反応例を見出しました。DOI： 10.1021/acs.orglett.1c00259
Other Link： https://pubs.acs.org/doi/10.1021/acs.orglett.1c00259
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Catalytic Enantioselective Synthesis of N,N‐Acetals from α‐Dicarbonyl Compounds Using Chiral Imidazoline‐Phosphoric Acid Catalysts Reviewed International journal
Shuichi Nakamura Tatsumi Wada Tsunayoshi Takehara Takeyuki Suzuki
Advanced Synthesis & Catalysis 2020.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley
ケトンの不斉アミナール化反応を開発しました。鎖状ケトンへの反応は難しいことが知られていましたが、我々の研究室で開発した触媒を用いることで高立体選択性の発現に成功しました。
Other Link： https://doi.org/10.1002/adsc.202001128
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piky-shaped niobium pentoxide nano-architecture: highly stable and recoverable Lewis acid catalyst Reviewed International journal
Teruaki Fuchigami, Mami Kuroda, Shuichi Nakamura, Masaaki Haneda and Ken-ichi Kakimoto
Nanotechnology 31 ( 32 ) 325705 - 325705 2020.04
Language：English Publishing type：Research paper (scientific journal) Publisher：IOP Science
spily型酸化ニオブのルイス酸特性の解明と有機合成への応用（名工大 柿本研、羽田研との共同研究）
Other Link： https://iopscience.iop.org/article/10.1088/1361-6528/ab8cf3
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Catalytic enantioselective decarboxylative nucleophilic addition reactions using chiral organocatalysts Invited Reviewed International journal
Kengo Hyodo, Shuichi Nakamura
Organic & Biomolecular Chemistry 2020.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：RSC
有機触媒を用いる脱炭酸型不斉求核付加反応の総合論文
DOI： 10.1039/D0OB00127A
Other Link： https://dx.doi.org/10.1039/D0OB00127A
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Enantioselective Vinylogous Mannich Reaction of Acyclic Vinylketene Silyl Acetals with Ketimines Using Chiral Bis(imidazoline)-Cu(II) Catalysts Reviewed International journal
Shuichi Nakamura,* Koichi Matsuzaka, Tsubasa Hatanaka, Yasuhiro Funahashi
Organic Letters 2020.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：ACS
直鎖系ビニルケテンシリルアセタールを用いるケチミン類への世界初のビニロガスMannich反応に成功した。また、さらに共役系を伸ばした求核剤をもちいビスビニロガスMannich反応の開発にも成功した
DOI： 10.1021/acs.orglett.0c00289
Other Link： https://dx.doi.org/10.1021/acs.orglett.0c00289
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Enantioselective conjugate addition of an a,a-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes Reviewed International journal
Shuichi Nakamura,* Akari Tokunaga, Hikari Saito, Masaru Kondo
Chemical Communications 55 ( 37 ) 5391 - 5394 2019.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：RSC
ジチオアセトニトリルの共役付加反応を世界で初めて可能としました。合成した化合物から、医薬品の有効成分であるロリプラム（抗炎症剤：選択的ホスホジエステラーゼ阻害薬）へと変換も行いました。
DOI： 10.1039/c9cc02443c
Other Link： http://dx.doi.org/10.1039/c9cc02443c
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Enantioselective Reaction of 2H-Azirines Reviewed International journal
Shuichi Nakamura*
Chemistry An Asian Journal 14 ( 9 ) 1323 - 1330 2019.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：RSC
アジリンの不斉反応について取りまとめた
Other Link： http://dx.doi.org/10.1002/asia.201900107
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Enantioselective Aza-Friedel-Crafts Reaction of Cyclic Ketimines with Indoles Using Chiral Imidazoline-Phosphoric Acid Catalysts Reviewed International journal
Shuichi Nakamura*, Takashi Furukawa, Tsubasa Hatanaka, Yasuhiro Funahashi
Chemical Communications 54 ( 31 ) 3811 - 3814 2018.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：RSC
環状のケチミンにインドール類を反応させるaza-Friedel-Crafts型反応の初めての例で、当研究室で開発した不斉イミダゾリン-リン酸触媒を用いることで成功した。
DOI： 10.1039/C8CC00594J
Other Link： http://dx.doi.org/10.1039/C8CC00594J
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Catalytic Enantioselective Reaction of 2H-Azirines with Thiols Using Cinchona Alkaloid Sulfonamide Catalysts Reviewed International journal
Shuichi Nakamura*, Daiki Hayama, Masataka Miura, Tsubasa Hatanaka, Yasuhiro Funahashi
Organic Letters 2018.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
アジリン類へのチオールの付加による光学活性N,S-アセタールの合成を検討した。不斉触媒として、これまでに当研究室で開発したシンコナアルカロイド-キノリンスルホンアミド触媒を利用したところ、高立体選択的に反応が進行することが明らかとなった。
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理論科学から化学産業へ：医薬品類の発展 Invited Reviewed
中村修一
化学史研究 44 ( 3 ) 144 - 149 2017.09
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
理論科学から化学産業への発展として、医薬品類の発展・展開について概説した。
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Catalytic Enantioselective Reaction of Allenylnitriles with Imines Using Chiral Bis(imidazoline)s-Palladium(II) Pincer Complexes Reviewed International journal
Masaru Kondo, Masashi Omori, Tsubasa Hatanaka, Yasuhiro Funahashi, Shuichi Nakamura
Angew. Chem. Int. Ed. 56 ( 30 ) 8677 - 8680 2017.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
独自に開発した不斉パラジウム触媒を用いることで、これまでに不斉合成反応において利用することができなかったアレニルニトリル類のイミン類への反応の開発に成功しました。合成した化合物群は、生物活性物質の合成中間体として利用が可能です。
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Enantioselective Reaction of 2H-Azirines with Phosphite Using Chiral Bis(imidazoline)/Zinc(II) Catalysts Reviewed
Shuichi Nakamura,* Daiki Hayama
Angew. Chem. Int. Ed. 56 ( 30 ) 8785 - 8789 2017.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
今回、独自に開発した不斉ビスイミダゾリン触媒を用いることで、これまでに不斉合成反応において、ほとんど利用されてこなかったアジリン類への高立体選択的不斉求核付加反応の開発に世界で初めて成功しました。
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Direct catalytic enantioselective Mannich-type reaction of a,a-dithioacetonitriles with imines using chiral bis(imidazoline)-Pd complexes Reviewed International journal
Masaru Kondo, Hikari Saito, Shuichi Nakamura*
Chemical Communications 53 ( 0 ) 6776 - 6779 2017.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：RSC
a,a-ジチオアセトニトリルを用いるイミン類への不斉求核付加反応の開発に成功した。触媒として、当研究室で開発しているビスイミダゾリン-Pd触媒を用いたところ、高立体選択的に反応が進行することが明らかとなった。また、ジチオ部分、ニトリル基部分の合成的変換にも成功した。
DOI： 10.1039/C7CC03307A
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Enantioselective Barbier-type Allylation of Ketones Using Allyl halide and Indium in Water Reviewed International journal
Shuichi Nakamura, Yoshichika Hara, Takashi Furukawa, Tsunehisa Hirashita
RSC Advances 7 ( 25 ) 15582 - 15585 2017.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
近年、環境調和型溶媒として、水が注目されている。そこで、ケトンへの水中での不斉アリル化反応を検討した。触媒として、当研究室で開発したt-ブチルカルボニル基を導入したイミダゾリン触媒を用い、藩王を検討したところ、比較的、高立体選択的に反応が進行することが明らかとなった。
DOI： 10.1039/c7ra01038a
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Enantioselective Oxidative Ring-Opening Reaction of Aziridines with Nitroesters Using Cinchona Alkaloid Amide/Nickel(II) Catalysts Reviewed International journal
Noriyuki Shiomi, Keisuke Yamamoto, Kazuma Nagasaki, Tsubasa Hatanaka, Yasuhiro Funahashi, Shuichi Nakamura
Organic Letters 19 ( 1 ) 74 - 77 2017.02
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
世界で初めて、アジリジンをニトロエステルの酸素部位で酸化的開環反応をして、光学活性αアミノケトンを合成した。用いる触媒としては、これまでに全く検討例のない、テトラゾールを導入したシンコナアルカロイド触媒で高立体的に生成物を得ることに成功した。
DOI： 10.1021/acs.orglett.6b03346
Other Link： http://pubs.acs.org/doi/abs/10.1021/acs.orglett.6b03346
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Desymmetrization of Aziridine with Malononitrile using Cinchona Alkaloid Amide/Zinc(II) Catalysts Reviewed International journal
Noriyuki Shiomi, Mami Kuroda, Shuichi Nakamura
Chemical Communicatios 53 ( 11 ) 1817 - 1820 2017.01
Language：English Publishing type：Research paper (scientific journal)
<font face="Times New Roman">アジリジンのマロノニトリルによる不斉非対称化反応を検討した。<span class="text_exposed_show">用いる触媒としては、当研究室でこれまでに開発してきたシンコナアルカロイド触媒を用いたところ、世界で初めて高立体的に生成物を得ることに成功した。</span></font>
DOI： 10.1039/C6CC09457K
Other Link： http://dx.doi.org/10.1039/C6CC09457K
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Direct catalytic enantioselective Mannich-type reaction of dichloroacetonitriles using chiral bis(imidazoline)-Pd catalysts Reviewed International journal
Masaru Kondo, Mami Sugimoto, Shuichi Nakamura
Chemical Communications 52 ( 93 ) 13604 - 13607 2016.10
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
我々の研究室で開発している触媒を用いて、様々な化合物に変換可能なa,a-ジクロロ-b-アミノニトリル類を高収率・高立体選択的に合成することに成功しました。
DOI： 10.1039/C6CC07982B
Other Link： http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc07982b#!divAbstract
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Highly Activated Second-Generation Grubbs-Hoveyda Catalyst Driven by Intramolecular Steric Strain Reviewed International journal
Yuki Kobayashi, Hiroki Miyazaki, Sae Inukai, Chika Takagi, Reo Makino, Kento Shimowaki, Rina Igarashi, Yuya Sugiyama, Shuichi Nakamura, Masato Matsugi
Synlett 27 ( 16 ) 2352 - 2356 2016.07
Language：English Publishing type：Research paper (scientific journal)
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Enantioselective Construction of Imidazolines Having Vicinal Tetra-substituted Stereocenters by Direct Mannich Reaction of a-Substituted a-Isocyanoacetates with Ketimines Reviewed International journal
Shuichi Nakamura,* Ryota Yamaji, Masaru Iwanaga
Chem. Commun. 52 ( 47 ) 7462 - 7465 2016.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：RSC
α置換イソニトリル化合物とケチミンとのMannich反応を検討しました。我々がこれまでに開発してきたシンコナアルカロイド-ピコリンアミド触媒を修飾することで、これまでに困難であった不活性型ケチミンへの反応によるイミダゾリン形成反応の開発に世界で初めて成功しました。
DOI： 10.1039/C6CC02911F
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Organocatalytic Enantioselective aza-Friedel-Crafts reaction of Cyclic Ketimines with Pyrroles using Imidazoline-phosphoric Acid Catalysts Reviewed International journal
Shuichi Nakamura,* Nazumi Matsuda, Mutsuyo Ohara
Chem. Eur. J. 22 ( 28 ) 9478 - 9482 2016.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley
これまでに困難とされていた環状ケチミンへのピロール類のFriedel-Crafts反応を検討しました。当研究室で開発したイミダゾリンリン酸触媒を用いることにより、高立体選択的に光学活性四置換不斉炭素を有するアミン類の合成に成功しました。
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Organocatalytic Enantioselective Conjugate Addition of Malonic Acid Half Thioesters to Coumarin-3-carboxylic Acids Using N-Heteroarenesulfonyl Cinchona Alkaloid Amides Reviewed
Shuichi Nakamura, Ayaka Toda, Masahide Sano, Tsubasa Hatanaka, Yasuhiro Funahashi
Advanced Synthesis & Catalysis 358 ( 7 ) 1029 - 1034 2016.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
マロン酸ハーフチオエステルのα,β-不飽和エステル類への共役付加反応を行いました。マロン酸ハーフチオエステルの共役付加反応はいくつか報告例が有りますが、α,β-不飽和エステルへの不斉反応例は、これまでに報告例がありませんでした。我々の研究室で開発した不斉有機分子触媒を用いることで、高収率・高立体選択的に生成物を得ることに成功しました。
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Enantioselective Reaction Using Palladium Pincer Complexes with C2-Symmetric Chiral Bis(imidazoline)s Invited Reviewed International journal
Shuichi Nakamura
J. Synth. Org. Chem. Jpn. 73 ( 11 ) 1062 - 1071 2015.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
これまでに我々が開発してきたビスイミダゾリン-Pd触媒について概説した。
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Catalytic enantioselective reaction of a-phenylthioacetonitriles using chiral bis(imidazoline)-Pd catalysts Reviewed International journal
Masaru Kondo, Natsumi Kobayashi, Tsubasa Hatanaka, Yasuhiro Funahashi, Shuichi Nakamura*
Chemistry - A European Journal 21 ( 25 ) 9066 - 9070 2015.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley-VCH
これまでに全く報告例のないαチオニトリルを求核剤にするイミンへの不斉求核付加反応を検討しました。我々がこれまでに研究を行ってきたビスイミダゾリン-Pd触媒を用いることで、世界ではじめてチオニトリルを用いる不斉反応に成功しました。
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Catalytic Enantioselective Reaction of α-Aminoacetonitriles Using Chiral Bis(imidazoline)-Pd Catalysts Reviewed
Masaru Kondo, Tomoki Nishi, Tsubasa Hatanaka, Yasuhiro Funahashi, Shuichi Nakamura*
Angewandte Chemie International Edition 54 ( 28 ) 8198 - 8202 2015.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
これまでにほとんど報告例のないαアミノニトリルを求核剤にするイミンへの不斉求核付加反応を検討しました。
我々がこれまでに研究を行ってきたビスイミダゾリン-Pd触媒を用いることで、高立体選択性の発現に成功しました。また、ジアゾ化合物との反応では、a,a-ジアミノニトリル化合物の合成にも成功しました。 -
Organocatalytic Enantioselective Peroxidation of Ketimines Derived from Isatins Reviewed
Shuichi Nakamura,* Shun Takahashi
Organic Letters 17 ( 11 ) 2590 - 2593 2015.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
これまでにまったく報告例のないヒドロペルオキシドとケチミンとの反応において我々オリジナルのヘテロアレーンスルホニル化シンコナアルカロイド触媒を利用することにより、光学活性α-アミノペルオキシドを合成することに成功しました。
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Direct Enantioselective Vinylogous Mannich Reaction of Ketimines with g-Butenolide by Using Cinchona Alkaloid Amide/Zinc(II) Catalysts Reviewed International journal
Shuichi Nakamura*, Ryota Yamaji, Masashi Hayashi
Chemistry - A European Journal 21 ( 27 ) 9615 - 9618 2015.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley-VCH
これまでにほとんど検討例のないγ-ブテノリドの直接的ビニロガスマンニッヒ反応を検討した。当研究室で開発してシンコナアルカロイド-ピコリンアミド型触媒を用いることで、高立体選択的に生成物を得ることに成功した。
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Organocatalytic Enantioselective Decarboxylative Reaction of Malonic Acid Half Thioesters with Cyclic N-Sulfonyl Ketimines Using N-Heteroarenesulfonyl Cinchona Alkaloid Amides Reviewed
Shuichi Nakamura*, Masahide Sano, Ayaka Toda, Daisuke Nakane, Hideki Masuda
Chemistry - A European Journal 2015.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
ケチミンへの脱炭酸型Mannich反応を検討した。当研究室で開発したスルホンアミド型触媒を用いることで、高エナンチオ選択的に生成物を得ることに成功した。触媒を使い分けることで、両鏡像異性体を作り分けることが可能となった。
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Organocatalytic Enantioselective Addition of Thiols to Ketimines Derived from Isatins Reviewed
Shuichi Nakamura,* Shun Takahashi, Daisuke Nakane, Hideki Masuda
Organic Letters inpress 2014.12
Language：English Publishing type：Research paper (scientific journal)
これまでに全く報告例のないケチミン類へのチオール類の付加反応を検討した。当研究室で以前開発した触媒を用いることで、世界ではじめて、高収率高エナンチオ選択的に生成物を得ることに成功し、触媒を使い分けることで、両鏡像異性体を作り分けられることを明らかにした。
DOI： 10.1021/ol503309s
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Desymmetrization of meso-Aziridines with TMSNCS Using Metal Salts of Novel Chiral ImidazolinePhosphoric Acid Catalysts Reviewed
Shuichi Nakamura, Mutsuyo Ohara, Madoka Koyari, Masashi Hayashi, Kengo Hyodo, Nadaf Rashid Nabisaheb, and Yasuhiro Funahashi
Organic Letters 16 ( 17 ) 4452 - 4455 2014.08
Language：English Publishing type：Research paper (scientific journal)
新規なイミダゾリン-リン酸ハイブリッド型触媒を設計・合成した。設計した触媒を用い、アジリジンのTMSNCSによる不斉開環反応を検討したところ、高立体選択的に反応が進行することが明らかとなった。得られた生成物は、生理活性物質に多く含まれるβ-アミノチオール、β-アミノスルホン酸へと変換することが出来た。
DOI： 10.1021/ol501990t
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Direct Asymmetric Mannich-Type Reaction of a-Isocyanoacetates with Ketimines using Cinchona Alkaloid Amide/Copper(II) Catalysts Reviewed
Masashi Hayashi, Masaru Iwanaga, Noriyuki Shiomi, Daisuke Nakane, Hideki Masuda, Shuichi Nakamura
Angewandte Chemie International Edition 53 ( 32 ) 8411 - 8415 2014.07
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
以前に我々が開発したキナアルカロイド-ピコリンアミド触媒を用い、ケチミンへのイソシアノエステルの付加によるイミダゾリン形成反応を高立体選択的に進行させることに成功した。
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Direct Enantioselective Three-Component Synthesis of Optically Active Propargylamines in Wa Reviewed
Mutsuyo Ohara, Yoshichika Hara, Tohru Ohnuki, Shuichi Nakamura
Chemistry - A European Journal 20 ( 29 ) 8848 - 8851 2014.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
新しい不斉触媒を開発し、アルデヒド、アミン、アルキンの三成分連結型反応を水中にて行うことに成功した。生成物は、塩析によって容易に水相と有機相が分離でき、簡便に精製できることが明らかとなった。
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Catalytic enantioselective decarboxylative reactions using organocatalysts Invited Reviewed
Shuichi Nakamura
Organic & Biomolecular Chemistry 3 ( 12 ) 394 - 405 2013.11
Language：English Publishing type：Research paper (scientific journal)
有機触媒的な脱炭酸型触媒的エナンチオ選択的不斉合成反応を概説した。
DOI： 10.1039/C3OB42161A
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Catalytic Enantioselective Allylation of Ketimines Using Palladium Pincer Complexes with Chiral Bis(imidazoline)s Reviewed
Shuichi Nakamura, Kengo Hyodo, Masayuki Nakamura, Daisuke Nakane, Hideki Masuda
Chemistry - A European Journal 23 ( 19 ) 7304 - 7309 2013.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
イサチンから誘導されるケチミンへの不斉触媒的アリル化反応を検討した。我々が以前に開発したビスイミダゾリン-パラジウムピンサー型触媒を用いることで、高立体選択的に反応が進行することが明らかとなった。
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Cinchona Alkaloid Amide/Copper(II) Catalyzed Diastereo- and Enantioselective Vinylogous Mannich Reaction of Ketimines with Siloxyfurans Reviewed
Masashi Hayashi, Masahide Sano, Yasuhiro Funahashi, Shuichi Nakamura
Angewandte Chemie International Edition 21 ( 52 ) 5557 - 5560 2013.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
ケチミンへのビニロガスマンニッヒ反応は、有用生理活性物質を合成する上で非常に有用な反応であるが、限定的な例でのみでしか、成功例は報告されていなかった。そこで、ケチミンへのビニロガスマンニッヒ反応において、我々が以前に開発した不斉触媒と酢酸銅を組み合わせ、反応を行った所、非常に高度の立体選択性が得られることが明らかとなった。
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Catalytic Enantioselective Decarboxylative Cyanoalkylation of Imines Using Palladium Pincer Complexes with C2-Symmetric Chiral Bis(imidazoline)s Reviewed
Kengo Hyodo, Masaru Kondo, Yasuhiro Funahashi and Shuichi Nakamura
Chemistry A European Journal 19 ( 13 ) 4128 - 4134 2013.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
イミンへのシアノ酢酸の脱炭酸型シアノメチル化反応を検討した。我々が開発してきたビスイミダゾリン-パラジウムピンサー型触媒を用いることで高度な立体制御に成功した。また、得られた生成物をPDE-4阻害剤へと誘導した。
Other Link： http://onlinelibrary.wiley.com/doi/10.1002/chem.201203782/abstract
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Cinchona Alkaloid Amides/Dialkylzinc Catalyzed Enantioselective Desymmetrization of Aziridines with Phosphites Reviewed
Masashi Hayashi, Noriyuki Shiomi, Yasuhiro Funahashi, and Shuichi Nakamura
J. Am. Chem. Soc. 47 ( 134 ) 19366 - 19369 2012.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
これまでに全く報告例のないアジリジンのリン化合物による不斉開環反応を検討した。我々が開発した新規キナアルカロイドアミド－亜鉛（II)触媒を用いることにより、高立体選択的に反応が進行し、βアミンのホスホン酸誘導体を与えることが明らかとなった。
DOI： 10.1021/ja309963w
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Enantioselective Aza-Morita-Baylis-Hillman Reaction of Acrylonitrile Catalyzed by Palladium(II) Pincer Complexes with C2-Symmetric Chiral Bis(imidazoline)s Reviewed
Kengo Hyodo, Shuichi Nakamura, and Norio Shibata
Angewandte Chemie International Edition 41 ( 51 ) 10337 - 10341 2012.10
Language：English Publishing type：Research paper (scientific journal)
我々が開発を行なってきたビスイミダゾリン-パラジウムピンサー型触媒を用い、アクリロニトリルへのaza-Morita-Bailys-Hillman反応を検討した。本触媒系では高エナンチオ選択的に反応が進行することが明らかとなった。アクリロニトリルへの反応の成功例は、全く報告されておらず、本邦が世界初の成功例となる。
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Enantioselective Synthesis of AG-041R Using N-Heteroarenesulfonyl Cinchona Alkaloid Amides Reviewed
Noriyuki Hara, Shuichi Nakamura, Masahide Sano, Ryota Tamura, Yasuhiro Funahashi, Norio Shibata
Chemistry A European Journal 30 ( 18 ) 9276 - 9280 2012.07
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
新規に開発したヘテロアレーンスルホニル基を有するキナアルカロイド触媒を用い、イサチンケチミンへの脱炭酸型Mannich反応を検討した。反応は高エナンチオ選択的に進行し、生理活性物質であるAG-041Rの不斉合成を達成した。本反応は、ケチミン類への不斉脱炭酸型Mannich反応の世界で初めての成功例となった。
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Enantioselective Synthesis of Imidazolines with Quaternary Stereocenters by Organocatalytic Reaction of N-(Heteroarenesulfonyl)imines with Isocyanoacetates Reviewed
Shuichi Nakamura, Yuri Maeno, Mutsuyo Ohara, Akiko Yamamura, Yasuhiro Funahashi, Norio Shibata
Organic Letters 12 ( 14 ) 2960 - 2963 2012.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
イミンへのイソシアニドの不斉求核付加－環化反応によるイミダゾリン形成反応を検討した。イミンとしてピリジルスルホニルイミンを用いることで高ジアステレオ、エナンチオ選択的に反応が進行し、4置換不斉炭素を有するイミダゾリン化合物の合成に成功した。4置換不斉炭素を有するイミダゾリン形成反応は世界初の例である。
DOI： 10.1021/ol301256q
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A fluorous Mukaiyama coupling reagent for a concise condensation reaction: utility of medium-fluorous strategy Reviewed
Yuya Sugiyama, Yuki Kurata, Yoko Kunda, Atsushi Miyazaki, Junko Matsui, Shuichi Nakamura, Hiromi Hamamoto, Takayuki Shioiri, Masato Matsugi
Tetrahedron 20 ( 68 ) 3885 - 3892 2012.05
Language：English Publishing type：Research paper (scientific journal)
フルオラス鎖を含有する向山縮合試薬を開発した。分子軌道計算によって反応性等の解明を行った。
DOI： 10.1016/j.tet.2012.03.034
Other Link： http://dx.doi.org/10.1016/j.tet.2012.03.034
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Direct Enantioselective Three-Component Kabachnik-Fields Reaction Catalyzed by Chiral Bis(imidazoline)-Zinc(II) Catalysts Reviewed
Mutsuyo Ohara, Shuichi Nakamura, Norio Shibata
Advanced Synthesis & Catalysis 18 ( 353 ) 3285 - 3289 2011.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
県境にやさしい多成分連結型の合成手法の開発は強く望まれている。本論文では、我々が開発したピリジンビスイミダゾリンー亜鉛錯体を用い、アルデヒド、アミン、亜リン酸エステルの三成分連結型反応による光学活性αアミノホスホン酸の合成を行った。これまでに、報告されている例は一例しかなく、本手法は基質一般性も高いことを明らかにした。
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Enantioselective Reaction of Imines and Benzylnitriles Using Palladium Pincer Complexes with C2-Symmetric Chiral Bis(imidazoline)s Reviewed
Kengo Hyodo, Shuichi Nakamura, Kotaro Tsuji, Takahiro Ogawa, Yasuhiro Funahashi, Norio Shibata
Advanced Synthesis & Catalysis 18 ( 353 ) 3385 - 3390 2011.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
光学活性なビスイミダゾリン-パラジウム（II)ピンサー型触媒を開発した。この触媒を用い、ベンジルシアニドのイミンへの不斉求核付加反応を検討したところ、高エナンチオ選択的に反応し、βアミノニトリル化合物を与えることを明らかにした。
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Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins Reviewed
Noriyuki Hara, Shuichi Nakamura, Yasuhiro Funahashi, Norio Shibata
Advanced Synthesis & Catalysis 16 ( 353 ) 2976 - 2980 2011.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
環境にやさしい有機触媒を用いる脱炭酸形アルドール反応を検討した。ケトン類への脱炭酸アルドール反応は未報告であり、本報告が世界初の例となる。本合成を活用し、有機触媒を用いるFlustraminol Bの触媒的エナンチオ選択的合成に成功した
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N-(Heteroarenesulfonyl)prolinamides-Catalyzed Aldol Reaction between Acetone and Aryl Trihalomethyl Ketones Reviewed
Noriyuki Hara, Ryota Tamura, Yasuhiro Funahashi, Shuichi Nakamura
Organic Letters 7 ( 13 ) 1662 - 1665 2011.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
新規の不斉有機触媒として8-キノリンスルホニル基を有するプロリンアミド触媒を設計合成した。この触媒を用いて、トリハロメチルケトン、イミンへの反応を検討したところ、高エナンチオ選択的にアルドール反応が進行することが明らかとなった。分子軌道計算を用いて、分子内水素結合が選択性の発現に重要な役割を果たしていることを明らかにした。
DOI： 10.1021/ol2001039
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Catalytic Enantioselective Protonation of a-Oxygenated Ester Enolates Prepared through Phospha-Brook Rearrangement Reviewed
Masashi Hayashi, Shuichi Nakamura
Angew. Chem. Int. Ed., 50 ( 10 ) 2249 - 2252 2011.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
ケトエステル類への亜リン酸の付加反応を、キナアルカロイド触媒と塩基を組み合わせて用いることで、高エナンチオ選択的にαリン酸エステル化エステルの合成に成功した。世界で初めてのa-オキシエノラートの触媒的エナンチオ選択的プロトン化であるとともに、世界で初めてのフォスファブルック転位によるエナンチオ選択的プロトン化例である。
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ヘテロアレーンスルホニル基を高機能性保護・活性化基として利用する不斉合成反応 Invited Reviewed
中村修一・柴田哲男・融 健
有機合成化学協会誌 10 ( 68 ) 1017 - 1027 2010.10
Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal)
これまでに我々が開発してきたヘテロアレーンスルホニル基を利用する不斉合成反応を概説した。
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Enantioselective Synthesis of Trifluoromethyl-Substituted 2-Isoxazolines: Asymmetric Hydroxylamine/Enone Cascade Reaction Reviewed
Kazutaka Matoba, Hiroyuki Kawai, Tatsuya Furukawa, Akihiro Kusuda, Etsuko Tokunaga, Shuichi Nakamura, Motoo Shiro, Norio Shibata
Angew. Chem. Int. Ed. 33 ( 49 ) 5762 - 5766 2010.07
Language：English Publishing type：Research paper (scientific journal)
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Enantioselective aldol reaction using recyclable montmorillonite-entrapped N-(2-thiophensulfonyl)prolinamide Reviewed
Noriyuki Hara, Shuichi Nakamura, Norio Shibata, and Takeshi Toru
Adv. Synth. Catal. 19 ( 352 ) 1621 - 1624 2010.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
これまでに我々が開発してきた高機能性有機触媒をモンモリロナイトに担持し、触媒の回収再利用に成功した。
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Enantioselective Desymmetrization of meso-N-(Heteroarenesulfonyl)aziridines with TMSN3 Catalyzed by Chiral Lewis Acids Reviewed
Shuichi Nakamura, Masashi Hayashi, Yasutoshi Kamada, Ryosuke Sasaki, Yuichi Hiramatsu, Norio Shibata and Takeshi Toru
Tetrahedron Letters 29 ( 51 ) 3820 - 3823 2010.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
アジリジンの不斉開環反応を行った。不斉触媒としてビスオキサゾリン-Mgを用い、窒素上に２－ピリジンスルホニル基を導入したところ、高エナンチオ選択的に生成物が得られた。得られた生成物から、生理活性物質であるU-50488を合成した。
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2-Fluoro-1,3-benzodithiole-1,1,3,3-tetraoxide: A Reagent for Nucleophilic Monofluoromethylation of Aldehydes Reviewed
Tatsuya Furukawa, Yosuke Goto, Jumpei Kawazoe, Etsuko Tokunaga, Shuichi Nakamura,Yudong Yang, Hongguang Du,, Akikazu Kakehi, Motoo Shiro, Norio Shibata
Angew. Chem. Int. Ed., 49 ( 9 ) 1642 - 1647 2010.01
Language：English Publishing type：Research paper (scientific journal)
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Copper-Catalyzed Enantioselective Three-Component Synthesis of Optically Active Propargylamines from Aldehyde, Amines, and Aliphatic Alkynes Reviewed
Shuichi Nakamura, Mutsuyo Ohara, Yuko Nakamura, Norio Shibata, Takeshi Toru
Chem. Eur. J. 16 ( 8 ) 2360 - 2362 2010.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Synthesis and Configurational Stability of (S)- and (R)-Deuteriothalidomides Reviewed
Takeshi Yamamoto, Etsuko Tokunaga, Shuichi Nakamura, Norio Shibata, and Takeshi Toru
Takeshi Yamamoto, Etsuko Tokunaga, Shuichi Nakamura, Norio Shibata, and Takeshi Toru The Chemical Society of Japan 1 ( 58 ) 110 - 112 2010.01
Language：English Publishing type：Research paper (scientific journal)
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Self-disproportionation of enantiomers of heterocyclic compounds having a tertiary trifluoromethyl alcohol center on chromatography with a non-chiral system Reviewed
Shinichi Ogawa, Takayuki Nishimine, Etsuko Tokunaga, Shuichi Nakamura, Norio Shibata
J. Fluorine Chem. 131 ( 4 ) 521 - 524 2010.01
Language：English Publishing type：Research paper (scientific journal)
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Pronounced rate enhancements in condensation reactions attributed to the fluorous tag in modified Mukaiyama reagents Reviewed
Masato Matsugi, Shuichi Nakamura, Yoko Kunda, Yuya Sugiyama, Takayuki Shioiri
Tetrahedron Lett 51 ( 1 ) 133 - 135 2010.01
Language：English Publishing type：Research paper (scientific journal)
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Efficient Access to Extended Yagupolskii-Umemoto-Type Reagents: Triflic Acid Catalyzed Intramolecular Cyclization of ortho-Ethynylaryltrifluoromethylsulfanes Reviewed
Andrej Matsnev, Shun Noritake, Yoshinori Nomura, Etsuko Tokunaga, Shuichi Nakamura, Norio Shibata
Angew. Chem. Int. Ed. 3 ( 49 ) 572 - 576 2009.12
Language：English Publishing type：Research paper (scientific journal)
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Catalytic Enantioselective Hydrophosphonylation of Ketimines Using Cinchona Alkaloids Reviewed
Shuichi Nakamura, Masashi Hayashi, Yuichi Hiramatsu, Norio Shibata, Yasuhiro Funahashi, Takeshi Toru
Journal of the American Chemical Society 51 ( 131 ) 18240 - 18241 2009.12
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Construction of Nonadjacent Stereocenters Containing a Trifluoromethylated Carbon by Organocatalyzed Michael Addition of b-Ketoesters to 2-(Trifluoromethyl)acrylate Reviewed
Shinichi Ogawa, Hiroyuki Yasui, Shuichi Nakamura, and Norio Shibata
Chemistry Letters 10 1006 - 1007 2009.10
Language：English Publishing type：Research paper (scientific journal)
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Design and Synthesis of Thalidomide-Deoxyribonucleoside Chimeras Reviewed
Shigeru Suzuki, Takeshi Yamamoto, Etsuko Tokunaga, Shuichi Nakamura, Motohiro Tanaka, Takuma Sasaki, and Norio Shibata
Chemistry Letters 11 1046 - 1047 2009.10
Language：English Publishing type：Research paper (scientific journal)
-
Asymmetric synthesis of a-fluoro-a-sulfenyl-b-ketoesters using DBFOX-Ph/Ni(II) complex Reviewed
Takehisa Ishimaru, Shinichi Ogawa, Etsuko Tokunaga, Shuichi Nakamura, Norio Shibata
Journal of Fluorin Chemistry 124 ( 11 ) 1049-1053 2009.08
Language：English Publishing type：Research paper (scientific journal)
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SolkaneR 365mfc is an environmentally benign alternative solvent for trifluoromethylation reactions Reviewed
Akihiro Kusuda, Hiroyuki Kawai, Shuichi Nakamura and Norio Shibata,
Green Chemistry 11 1733 - 1735 2009.08
Language：English Publishing type：Research paper (scientific journal)
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Catalytic Enantioselective Trifluoromethylation of Azomethine Imines with Trimethyl(trifluoromethyl)silane Reviewed
Hiroyuki Kawai, Akihiro Kusuda, Shuichi Nakamura, Motoo Shiro, Norio Shibata
Angew. Chem. Int. Ed., 34 ( 48 ) 6324 - 6327 2009.07
Language：English Publishing type：Research paper (scientific journal)
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Synthesis, photophysical and electrochemical properties of perfluoroisopropyl substituted binuclear phthalocyanine conjugated with a butadiyne linker Reviewed
Norio Shibata, Banibrata Das, Masamichi Hayashi, Shuichi Nakamura, Takeshi Toru
Journal of Fluorin Chemistry 12 ( 124 ) 1164 - 1170 2009.07
Language：English Publishing type：Research paper (scientific journal)
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Synthesis, Configurational Stability and Stereochemical Biological Evaluations of (S)- and (R)-5-Hydroxythalidomides Reviewed
Takeshi Yamamoto, Norio Shibata, Daisuke Sukeguchi, Masayuki Takashima,Shuichi Nakamura, Takeshi Toru, Nozomu Matsunaga, Hideaki Hara, Motohiro, Tanaka, Tohru Obata, Takuma Sasaki
Bioorg. Med. Chem. Lett. 14 ( 19 ) 3973 - 3976 2009.07
Language：English Publishing type：Research paper (scientific journal)
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A DBFOX-Ph-Based Combinatorial Catalyst for Enantioselective Fluorination of Aryl Acetyl and 3-Butenoyl Thiazolidinones Reviewed
Dhande Sudhakar Reddy, Norio Shibata, Takao Horikawa, Satoru Suzuki, Shuichi Nakamura, Takeshi Toru, Motoo Shiro
Chemistry - An Asian Journal 9 ( 4 ) 2009.06
Language：English Publishing type：Research paper (scientific journal)
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Synthesis of novel C2-symmetric chiral crown ethers and their application to enantioselective trifluoromethylation of aldehydes and ketones Reviewed
Hiroyuki Kawai, Akihiro Kusuda, Satoshi Mizuta, Shuichi Nakamura, Yasuhiro Funahashi, Hideki Masuda, Norio Shibata
Journal of Fluorin Chemistry 8 ( 130 ) 762 - 765 2009.06
Language：English Publishing type：Research paper (scientific journal)
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Enantioselective electrophilic trifluoromethylation of b-keto esters with Umemoto reagents induced by chiral nonracemic guanidines Reviewed
Shun Noritake, Norio Shibata, Yoshinori Nomura, Yiyong Huang, Andrej Matsnev, Shuichi Nakamura, Takeshi Toru and Dominique Cahard
Org. Biomol. Chem ( 7 ) 3599 - 3604 2009.06
Language：English Publishing type：Research paper (scientific journal)
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First Enantioselective Synthesis of (R)-Convolutamydine B and E with N-(Heteroarenesulfonyl)prolinamides Reviewed
Noriyuki Hara, Shuichi Nakamura, Norio Shibata, Takeshi Toru
Chemistry - A European Journal 28 ( 15 ) 6790 - 6793 2009.06
Language：English Publishing type：Research paper (scientific journal)
-
Organocatalytic Enantioselective Aza-Friedel-Crafts Alkylation of Pyrroles with N-(Heteroarenesulfonyl)imines. Invited Reviewed
Shuichi Nakamura, Yuki Sakurai, Hiroki Nakashima, Norio Shibata, Takeshi Toru
Synlett ( 10 ) 1639 - 1642 2009.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Synthesis of Covalently Linked Phthalocyanine-C60 Dyad via a Flexible Carbon Linker Reviewed
Daisuke Sukeguchi, Hideyuki Yoshiyama, Surya Prakash Singh, Norio Shibata, Shuichi Nakamura, Takeshi Toru, Yasuhiko Hayashi and Tetsuo Soga
Heterocycl. Commun. 3 ( 15 ) 195 - 202 2009.06
Language：English Publishing type：Research paper (scientific journal)
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A Dynamic Kinetic Asymmetric Transformation in the -Hydroxylation of Racemic Malonates and Its Application to Biologically Active Molecules Reviewed
Dhande Sudhakar Reddy, Norio Shibata, Jun Nagai, Shuichi Nakamura, Takeshi Toru
Angew. Chem. Int. Ed 48 ( 4 ) 803 - 806 2009.06
Language：English Publishing type：Research paper (scientific journal)
-
Synthesis of trifluoroethoxy-coated binuclear phthalocyanines with click spacers and investigation of their clamshell behaviour Reviewed
Hideyuki Yoshiyama, Norio Shibata, Takefumi Sato, Shuichi Nakamura and Takeshi Toru
Org. Biomol. Chem. 11 ( 7 ) 2265 - 2269 2009.04
Language：English Publishing type：Research paper (scientific journal)
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Ionic Liquids as Media for Nucleophilic Ring Opening Fluorination of Aziridines Reviewed
Shun Noritake, Norio Shibata, Hiroyuki Kawai, Manoj Kumar Pandy, Shuichi Nakamura, Takeshi Toru
Heterocycl. Commun., 15 ( 2 ) 105 - 113 2009.04
Language：English Publishing type：Research paper (scientific journal)
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New diarylmethanofullerene derivatives and their properties for organic thin- film solar cells Reviewed
Daisuke Sukeguchi, Surya Prakash Singh, Mamidi Ramesh Reddy, Hideyuki Yoshiyama, Rakesh A. Afre, Yasuhiko Hayashi, Hiroki Inukai, Tetsuo Soga, Shuichi Nakamura, Norio Shibata, Takeshi Toru
Beilstein Journal of Organic Chemistry 7 ( 5 ) 2009.02
Language：English Publishing type：Research paper (scientific journal)
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Synthesis and spectroscopic investigation of trifluoroethoxy-coated phthalocyanine linked with fullerene Reviewed
Daisuke Sukeguchi, Hideyuki Yoshiyama, Norio Shibata, Shuichi Nakamura, Takeshi Toru, Yasuhiko Hayashi, Tetsuo Soga
Journal of Fluorin Chemistry 3 ( 130 ) 361 - 364 2008.12
Language：English Publishing type：Research paper (scientific journal)
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A Novel Enantiocomplementary C2-Symmetric Chiral Bis(imidazoline) Ligands: Highly Enantioselective Friedel-Crafts Alkylation of Indoles with Ethyl 3,3,3-Trifluoropyruvate Reviewed
Shuichi Nakamura, Kengo Hyodo, Yuko Nakamura, Norio Shibata, Takeshi Toru
Adv. Synth. Catal. 350 ( 10 ) 1443 - 1448 2008.06
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Organocatalytic Enantioselective Hydrophosphonylation of Sulfonylimines Having Heteroarylsulfonyl Group as a Novel Reviewed
Shuichi Nakamura, Hiroki Nakashima, Akiko Yamamura, Norio Shibata, Takeshi Toru
Adv. Synth. Catal. 350 ( 10 ) 1209 - 1212 2008.05
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Enantioselective C-C bond Formation to Sulfonylimines Using 2-Pyridylsulfonyl Group as a Novel Stereocontroller Reviewed
Shuichi Nakamura, Hiroki Nakashima, Hideki Sugimoto, Hideaki Sano, Masataka Hattori, Norio Shibata and Takeshi Toru
Chemistry - A European Journal 14 ( 7 ) 2145 - 2152 2008.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Confirmation of the Stereostructure of (+)-Cytostatin by Fluorous Mixture Synthesis of Four Candidate Stereoisomers Reviewed
Won-Hyuk Jung, Sabrina Guyenne, Concepcion Riesco-Fagundo, John Mancuso, Shuichi Nakamura, Dennis P. Curran
Angewandte Chemie International Edition 47 ( 6 ) 1130 - 1133 2008.01
Language：English Publishing type：Research paper (scientific journal)
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Highly Enantioselective Reactions of a-Sulfonyl Carbanion of Trifluoromethyl Sulfones Reviewed
Shuichi Nakamura, Norimune Hirata, Takeshi Kita, Ryusuke Yamada, Daisuke Nakane, Norio Shibata, Takeshi Toru
Angew. Chem. Int. Ed. 46 ( 40 ) 7648 - 7650 2007.08
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Asymmetric Synthesis of Axially Chiral cis-arylmethylenebicyclo[3.3.0]octanes Using a-Thio- and a-Selenoorganolithium Compounds Reviewed
Libo Wang, Shuichi Nakamura, Norio Shibata, and Takeshi Toru
Chem. Lett. 34 ( 1 ) 76 - 77 2005.01
Language：English Publishing type：Research paper (scientific journal)
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Enantioselective Reaction of a-Lithiated Thiazolidines as new chiral formyl anion equivalents Reviewed
Libo Wang, Shuichi Nakamura, Yuji Ito, and Takeshi Toru
Tetrahedron: Asymmetry 15 ( 19 ) 2004.10
Language：English Publishing type：Research paper (scientific journal)
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The Synthesis of Metal-Free Phthalocyanines from Phthalonitriles with Hexamethyldisilazane Reviewed
H. Uchida, H. Yoshiyama, P. Y. Reddy, S. Nakamura, and T. Toru
Bull. Chem. Soc. Jpn. 77 ( 7 ) 1401 - 1404 2004.07
Language：English Publishing type：Research paper (scientific journal)
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A New Approach to Enantioselective Cyanation of Imines with Et2AlCN Reviewed
Shuichi Nakamura, Naoki Sato, Masashige Sugimoto and Takeshi Toru
Tetrahedron: Asymmetry 15 ( 9 ) 1513 - 1516 2004.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
A novel method for the preparation of benzylidenecyclohexanes with high optical purity Reviewed
Shuichi Nakamura, Takahiro Ogura, Libo Wang and Takeshi Toru
Tetrahedron Lett. 45 ( 11 ) 2399 - 2402 2004.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Highly Enantioselective Reaction of a-Selenoorganolithium Compounds Using Chiral Bis(oxazoline)s and Preparation of Enantioenriched Benzylidencyclohexanes Reviewed
Shuichi Nakamura, Takayuki Aoki, Takahiro Ogura, Libo Wang and Takeshi Toru
J. Org. Chem 69 ( 25 ) 8916 - 8923 2004.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1021/jo048505l
-
Libo Wang, Shuichi Nakamura, and Takeshi Toru
Organic & Biomolecular Chemistry 2 ( 15 ) 2168 - 2169 2004.01
Language：English Publishing type：Research paper (scientific journal)
-
Enantioselective Reaction of a-Lithiated Dithioacetals Using Chiral Bis(oxazoline)s: New Chiral Formyl Anion Equivalents Reviewed
Shuichi Nakamura, Yuji Ito, Libo Wang, and Takeshi Toru
The Journal of Organic Chemistry 69 ( 5 ) 1581 - 1589 2004.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Enantioselective Radical Cyclization ofa,b-Unsaturated Sulfonyl Compounds Invited Reviewed
Hideki Sugimoto, Makoto Kobayashi, Shuichi Nakamura, and Takeshi Toru
Tetrahedron Letters 45 ( 22 ) 4213 - 4216 2004.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Enantioselective Reactions of a-Lithiated Allyl Aryl Sulfides Using Chiral Bis(oxazoline)s Reviewed
Shuichi Nakamura, Toru Kato, Haruka Nishimura and Takeshi Toru
Chirality 16 ( 2 ) 86 - 89 2004.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Novel Chiral Sulfur-Containing Ferrocenyl Ligands for Palladium-Catalyzed Asymmetric Allylic Substitution Reviewed
Shuichi Nakamura, Takeo Fukuzumi, Takeshi Toru
Chirality 16 ( 1 ) 10 - 12 2004.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Solvent-Free Efficient Synthesis of 2,4,5-Triarylimidazolines from Aromatic aldehydes and Hexamethyldisilazane Reviewed
Hitoshi Uchida, Takashi Shimizu, Paidi Yella Reddy, Shuichi Nakamura, Takeshi Toru
Synthesis ( 8 ) 1236 - 1240 2003.04
Language：English Publishing type：Research paper (scientific journal)
-
Novel Synthesis of Metal-Free Phthalocyanines from Phthalimides and Phthalic Anhydrides with Hexamethyldisilazane Reviewed
Hitoshi Uchida, Hideyuki Yoshiyama, Paidi Yella Reddy, Shuichi Nakamura, Takeshi Toru
Synlett ( 13 ) 2083 - 2085 2003.04
Language：English Publishing type：Research paper (scientific journal)
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Novel Efficient Preparative Method for Phthalocyanines from Phthalimides and Phthalic Anhydride with HMDS Reviewed
Hitoshi Uchida, Paidi Yella Reddy, Shuichi Nakamura, Takeshi Toru
J. Org. Chem 68 ( 22 ) 8736 - 8738 2003.04
Language：English Publishing type：Research paper (scientific journal)
-
Microwave-Assisted Rapid and Selective Synthesis of cis- and trans-2,4,5-Triarylimidazolines from Aromatic Aldehydes Reviewed
Hitoshi Uchida, Hirofumi Tanikoshi, Shuichi Nakamura, Paidi Yella Reddy, Takeshi Toru
Synlett ( 8 ) 1117 - 1120 2003.04
Language：English Publishing type：Research paper (scientific journal)
-
Enantioselective Hydrogen Atom Transfer to α-Sulfonyl Radicals Controlled by Selective Coordination of a Chiral Lewis Acid to an Enantiotopic Sulfonyl Oxygen Invited Reviewed
Hideki Sugimoto, Shuichi Nakamura, Yoshihiko Watanabe and Takeshi Toru
Tetrahedron: Asymmetry 14 ( 19 ) 3043 - 3055 2003.01
Language：English Publishing type：Research paper (scientific journal)
-
Asymmetric reduction of a-(trimethylsilyl)methyl-b-ketosulfoxide with DIBAL under basic conditions Reviewed
Shuichi Nakamura, Jun-ichi Nakayama, and Takeshi Toru
J. Org. Chem 68 ( 14 ) 5766 - 5768 2003.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Preparation of Optically Pure Propargylic and Allylic Alcohols from 2-(Trimethylsilyl)vinyl Sulfoxides as a Chiral Ethynyl Anion Synthon: Computational Studies on Elimination Reaction of 2-(Trimethylsilyl)vinyl Sulfoxides Reviewed
Shuichi NAKAMURA, Sinya KUSUDA, Kiyoshi KAWAMURA, Takeshi TORU
Journal of Organic Chemistry 63 ( 3 ) 640 - 647 2002.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Novel Synthesis of Phthalocyanines from Phthalonitriles under Mild Conditions Reviewed
Hitoshi UCHIDA, Hirokazu TANAKA, Hideyuki YOSHIYAMA, Paidi Yella REDDY, Shuichi NAKAMURA, Takeshi TORU
Synlett 1649 - 1652 2002.04
Language：English Publishing type：Research paper (scientific journal)
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Diastereoselective Reaction of [1-(2,4,6-Triisopropylphenylsulfinyl)-2-naphthyl]methanimines via Diastereomeric Rotamers Reviewed
Shuichi NAKAMURA, Hiroki YASUDA, and Takeshi TORU
Tetrahedron: Asymmetry 13 1509 - 1518 2002.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Asymmetric Conjugate Addition Reactions of Polymer-Supported Highly Enantioenriched b-(Trimethylsilyl)ethyl Sulfoxides Reviewed
Shuichi Nakamura, Youhei Uchiyama, Satoshi Ishikawa, Ryuta Fukinbara, Yoshihiko Watanabe, Takeshi Toru
Tetrahedron Letters 43 ( 13 ) 2381 - 2383 2002.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Highly Enantioselective Reaction of a-Lithio 2-Quinolyl Sulfide Using Chiral Bis(oxazoline)s: New Synthesis of Enantioenriched Thiols Reviewed
Shuichi Nakamura, Akinori Furutani, Takeshi Toru
European Journal of Organic Chemistry ( 10 ) 1690 - 1695 2002.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Stereoselective aldol reaction of a-seleno carbonyl compounds: preparation of (Z)-a,b-unsaturated carbonyl compounds Reviewed
Shuichi NAKAMURA, Toshinobu HAYAKAWA, Tatsuya NISI, Yoshihiko WATANABE, Takeshi TORU
Tetrahedron 57 ( 31 ) 6703 - 6711 2001.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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1,4-Asymmetric Reduction of g-Ketosulfoxides Bearing the 2,4,6-Triisopropylphenyl Group Reviewed
Shuichi NAKAMURA, Masayuki KUROYANAGI, Yoshihiko WATANABE, Takeshi TORU
The Journal of Chemical Society, Perkin Transaction 1 ( 18 ) 3143 - 3148 2000.09
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Stereoselective Reaction of a-Sulfinyl Carbanion Derived from Chiral 2-(Trialkylsilyl)ethyl Sulfoxides: Evidence for a Novel Silicon-Oxygen Interaction Reviewed
Shuichi NAKAMURA, Hirofumi TAKEMOTO, Yoshio UENO, Takeshi TORU, Terumitsu KAKUMOTO, Tsuneo HAGIWARA
The Journal of Organic Chemistry 65 ( 2 ) 469 - 474 2000.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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New Asymmetric Reactions of 2-Formyl- and 2-Acyl-1-[(2,4,6-triisopropylphenyl) sulfinyl]naphthalenes via Diastereomeric Rotamers Reviewed
Shuichi NAKAMURA, Hiroki Yasuda, Yoshihiko WATANABE,Takeshi TORU
The Journal of Organic Chemistry 65 ( 25 ) 8640 - 8650 2000.04
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Diastereoselective reaction of 1-(arylsulfinyl)-2-naphthaldehydes Reviewed
Shuichi NAKAMURA, Hiroki YASUDA, Yoshihiko WATANABE, Takeshi TORU
Tetrahedron Letters 41 ( 21 ) 4157 - 4160 2000.03
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
-
Enantioselective Reactions of Configurationally Unstable a-Thiobenzyllithiums Compounds Reviewed
Shuichi NAKAMURA, Ryo NAKAGAWA, Yoshihiko WATANABE, Takeshi TORU
Angewandte Chemie International Edition 39 ( 2 ) 353 - 355 2000.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Extremely Efficient Chiral Induction in Conjugate Additions of a-Lithio-b-(trimethylsilyl)ethyl Sulfoxide and Subsequent Electrophilic Trapping Reactions Reviewed
Shuichi NAKAMURA, Yoshihiko WATANABE, Takeshi TORU
The Journal of Organic Chemistry 65 ( 6 ) 1758 - 1766 2000.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Highly Enantioselective Reactions of Configurationally Labile a-Thioorganolithiums Using Chiral Bis(oxazoline)s via Two Different Enantiodetermining Steps Reviewed
Shuichi NAKAMURA, Ryo NAKAGAWA, Yoshihiko WATANABE, Takeshi TORU
Journal of the American Chemical Society 122 ( 46 ) 11340 - 11347 2000.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Efficient synthesis of chrysanthemate precursor from chiralp-tolyl b-(trimethylsilyl)ethyl sulfoxide Reviewed
Shuichi NAKAMURA, Yoshihiko WATANABE, Takeshi TORU
The Journal of Chemical Society, Perkin Transaction 1 ( 23 ) 3403 - 3404 1999.11
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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Stereoselective Conjugate Addition of an a-Sulfinyl Carbanionto a,b-Unsaturated Ester: Asymmetric Synthesis of Cycloalkanecarboxylates Invited Reviewed
Takeshi TORU, Shuichi NAKAMURA, Hirofumi TAKEMOTO, Yoshio UENO
SYNLETT ( 5 ) 449 - 450 1997.04
Language：English Publishing type：Research paper (scientific journal)
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Nobuyuki Mase, Yoshihiko Watanabe, Koji Higuchi, Shuichi Nakamura, and Takeshi Toru
J. Chem. Soc. Perkin Trans. 1 2134 - 2136 1996.01
Language：English Publishing type：Research paper (scientific journal)
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Sulfinyl-Induced Highly Stereoselective 1,4-Asymmetric Reactions of 2-(Arylsulfinyl)benzaldehydes and 2-(Arylsulfinyl)phenyl Ketones Reviewed
Shuichi NAKAMURA, Masahiro ODA, Hiroki YASUDA, Takeshi TORU
Tetrahedron 57 ( 40 ) 8469 - 8480 1996.01
Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
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