TSUKIJI Shinya

写真a

Affiliation Department

Department of Life Science and Applied Chemistry
Department of Life Science and Applied Chemistry
Frontier Laboratory

Title

Professor

Contact information

Contact information

Homepage

http://tsukijilab.web.nitech.ac.jp/index-e.html

External Link

Degree

  • Doctor (Engineering) ( 2001.03   Kyushu University )

Research Areas

  • Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules

  • Nanotechnology/Materials / Chemical biology

  • Nanotechnology/Materials / Bio chemistry

From School

  • Kyushu University   Faculty of Engineering   Department of Chemical Science & Technology   Graduated

    - 1996.03

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    Country:Japan

From Graduate School

  • Kyushu University   Graduate School, Division of Engineering   Department of Chemistry and Biochemistry   Doctor's Course   Completed

    - 2001.03

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    Country:Japan

  • Kyushu University   Graduate School, Division of Engineering   Department of Chemistry and Biochemistry   Master's Course   Completed

    1996.04 - 1998.03

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    Country:Japan

External Career

  • Nagoya University

    2019.10

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    Country:Japan

  • Nagoya University

    2017.04 - 2017.09

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    Country:Japan

  • Nagoya City University

    2016.10 - 2017.03

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    Country:Japan

  • Nagaoka University of Technology

    2015.10 - 2016.03

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    Country:Japan

 

Papers

  • Chemogenetic manipulation of endogenous proteins in fission yeast using a self-localizing ligand-induced protein translocation (SLIPT) system

    Akinobu Nakamura, Yuhei Goto, Hironori Sugiyama, Shinya Tsukiji, Kazuhiro Aoki

    ACS Chemical Biology   in press   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Chemogenetic manipulation of endogenous proteins in fission yeast using a self-localizing ligand-induced protein translocation (SLIPT) system

    Akinobu Nakamura, Yuhei Goto, Hironori Sugiyama, Shinya Tsukiji, Kazuhiro Aoki

    bioRxiv   2023.07

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1101/2023.07.27.550911

    Other Link: https://www.biorxiv.org/content/10.1101/2023.07.27.550911v2

  • Hierarchical supramolecular structure comprising reduction-responsive DNA microspheres and semi-artificial glycopeptide-based micro-asters Reviewed

    Ayaka Isogami, Sayuri L. Higashi, Bioru Okumura, Aya Shibata, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Shinya Tsukiji, Kazunori Matsuura, Masato Ikeda

    Polymer Journal   55   1103 - 1107   2023.06

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1038/s41428-023-00809-1

    Other Link: https://www.nature.com/articles/s41428-023-00809-1

  • Revisit of the plasmon-mediated chemical transformation of para-aminothiophenol Reviewed

    Toshiki Kondo, Motoharu Inagaki, Shohei Tanaka, Shinya Tsukiji, Kenta Motobayashi, Katsuyoshi Ikeda

    Physical Chemistry Chemical Physics   25   14618 - 14626   2023.05

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1039/D3CP00924F

    Other Link: https://pubs.rsc.org/en/content/articlelanding/2023/cp/d3cp00924f

  • Palmitoylation-dependent small-molecule fluorescent probes for live-cell Golgi imaging Reviewed

    Shunsuke Sawada, Masaru Yoshikawa, Keita Tsutsui, Tomoki Miyazaki, Keiko Kano, Emi Mishiro-Sato, Shinya Tsukiji

    ACS Chemical Biology   18   1047 - 1053   2023.04

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1021/acschembio.3c00046

    Other Link: https://pubs.acs.org/doi/10.1021/acschembio.3c00046

  • Editorial overview: Synthetic biomolecules for probing lipid membranes International coauthorship

    Neal K. Devaraj, Shinya Tsukiji

    Current Opinion in Chemical Biology   73   102271   2023.02

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.cbpa.2023.102271

    Other Link: https://www.sciencedirect.com/science/article/abs/pii/S1367593123000091

  • Chemo- and opto-genetic tools for dissecting the role of membrane contact sites in living cells: recent advances and limitations Reviewed

    Fubito Nakatsu, Shinya Tsukiji

    Current Opinion in Chemical Biology   73   102262   2023.01

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.cbpa.2022.102262

    Other Link: https://www.sciencedirect.com/science/article/abs/pii/S1367593122001478

  • Miniaturized synthetic palmitoylation motifs for small-molecule localization in living cells Reviewed International coauthorship

    Sachio Suzuki, Masaru Yoshikawa, Shunsuke Sawada, Neal K. Devaraj, Shinya Tsukiji

    Bioconjugate Chemistry   34   169 - 173   2022.12

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1021/acs.bioconjchem.2c00517

    Other Link: https://pubs.acs.org/doi/10.1021/acs.bioconjchem.2c00517

  • A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration Reviewed International coauthorship

    Naoya Hino, Kimiya Matsuda, Yuya Jikko, Gembu Maryu, Katsuya Sakai, Ryu Imamura, Shinya Tsukiji, Kazuhiro Aoki, Kenta Terai, Tsuyoshi Harashima, Xavier Trepat, Michiyuki Matsuda

    Developmental Cell   57   2290 - 2304   2022.09

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    Language:English   Publishing type:Research paper (scientific journal)  

  • A peptide nanocage constructed by self-assembly of oligoproline conjugates Reviewed

    Shogo Matsubara, Yui Okamoto, Masaru Yoshikawa, Shinya Tsukiji, Masahiro Higuchi

    Bioconjugate Chemistry   33   1785 - 1788   2022.07

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    Language:English   Publishing type:Research paper (scientific journal)  

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Misc

  • 光-化学遺伝学による細胞内タンパク質の局在操作

    吉井達之, 築地真也

    16 ( 1 )   7 - 9   2023.05

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

  • ケモジェネティクスによる細胞夾雑環境でのタンパク質活性操作

    築地真也

    Part II ( 9章 )   86 - 92   2023.02

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

    Other Link: https://www.kagakudojin.co.jp/book/b615061.html

  • SLIPT-PMシステムを用いた細胞内シグナル操作

    築地真也, 鈴木祥央

    75 ( 12 )   879   2022.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

    Other Link: https://www.chemistry.or.jp/division-topics/2022/11/slipt-pm.html

  • タンパク質活性を隔離・放出する人工相分離ドロップレット

    築地真也, 吉川優

    32 ( 3 )   140 - 144   2022.08

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

  • メンブレンコンタクトの化学遺伝学操作を介した膜脂質代謝の可逆制御

    吉川優, 阿喰萌香, 中津史, 築地真也

    36 ( 2 )   30 - 31   2021.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)  

  • 細胞内相分離を理解・操作・活用する人工相分離ツール

    築地真也, 吉川優

    39   204 - 210   2021.06

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  • 局在性リガンドによる細胞夾雑空間でのタンパク質局在操作

    築地真也

    53   58 - 62   2021.04

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  • 生命現象の操作と可視化のための細胞内人工相分離ツール

    吉川優, 吉井達之, 築地真也

    98 ( 5 )   246 - 250   2020

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  • 生細胞内に人工ドロプレットをつくる:合成相分離生物学

    築地真也

    第V部 ( 44章 )   220 - 224   2020

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  • 単一細胞内の局所プロトン濃度を測る蛍光センサー:古典的手法から新展開まで

    築地真也

    88 ( 3 )   240 - 245   2020

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Presentations

  • 分割型ケモジェネティック蛍光プローブを用いた膜-膜接触部位の可視化

    阿喰萌香、吉川優、筒井啓太、中津史、築地真也

    第46回日本分子生物学会年会 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Poster presentation  

  • 小分子やペプチドを細胞膜内葉に送達する合成モチーフの開発

    王笑桐、澤田隼佑、吉川優、飯島共女、筒井啓太、築地真也

    第46回日本分子生物学会年会 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Poster presentation  

  • pH応答性光増感剤開発に向けたペプチド‐クロロフィル複合体

    永谷美裕、吉川優、築地真也、樋口真弘、民明均、松原翔吾

    第33回日本MRS年次大会 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 進化分子工学による cis 型アゾベンゼン特異的人工抗体の創製と光細胞操作ツールへの応用

    宮崎友輝、藤野公茂、吉井達之、舟根守、村田直哉、Kim Chung Nguyen、田原海、吉川優、深谷菜摘、長門石曉、津本浩平、林剛介、村上裕、築地真也

    第61回日本生物物理学会年会 

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    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (general)  

  • Designer protein condensates for cell signal manipulation Invited

    Shinya Tsukiji

    第61回日本生物物理学会 シンポジウム「構造生物学的アプローチに基づく液液相分離(LLPS)の機能解明」 

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    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  • 小分子薬剤に応答してタンパク質活性の隔離・放出を誘導する 人工非膜オルガネラ技術

    深谷陽子、吉川優、築地真也

    第40回メディシナルケミストリーシンポジウム 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Poster presentation  

  • 小分子化合物や中分子ペプチドの細胞膜内葉デリバリーツール

    王笑桐、澤田隼佑、吉川優、飯島共女、筒井啓太、築地真也

    第40回メディシナルケミストリーシンポジウム 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Poster presentation  

  • 人工相分離オルガネラによる細胞操作 Invited

    築地真也

    第13回CSJ化学フェスタ2023 テーマ企画「コロナで変わった・進んだバイオと化学〜生体分子の集合体と相分離が拓く新しい化学〜」 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  • 人工細胞バイオセンサーの開発

    筒井啓太、吉川優、築地真也

    第1回ケミカルバイオ超分子研究会 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 進化分子工学を利用した細胞機能の光可逆制御を可能にするcis型アゾベンゼン特異的人工抗体タグの創製

    宮崎友輝、藤野公茂、吉井達之、舟根守、村田直哉、Chung Nguyen Kim、田原海、吉川優、深谷菜摘、長門石曉、津本浩平、林剛介、村上裕、築地真也

    第1回ケミカルバイオ超分子研究会 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

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Industrial Property Rights

  • 細胞膜非透過性の物質を動物細胞の細胞質に送達する新規キャリア分子

    築地真也, 澤田隼佑

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    Applicant:国立大学法人名古屋工業大学

    Application no:特開2022-029516  Date applied:2022.02

    Country of applicant:Domestic   Country of acquisition:Domestic

  • フィブロネクチンIII型ドメイン骨格を含むポリペプチド

    村上裕, 都築成晃, 近藤太志, 林剛介, 藤野公茂, 築地真也, 吉井達之

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    Applicant:国立大学法人東海国立大学機構, 国立大学法人名古屋工業大学

    Application no:特願2020-145463  Date applied:2020.08

    Announcement no:WO 2022/045365 A1  Date announced:2022.03

    Country of applicant:Domestic   Country of acquisition:Domestic

  • ゴルジ体に局在する化合物及びその使用

    築地真也, 中村彰伸, 澤田隼佑, 吉井達之

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    Applicant:国立大学法人名古屋工業大学

    Application no:特願2020-141893  Date applied:2020.08

    Announcement no:特開2022-37654  Date announced:2022.03

    Country of applicant:Domestic   Country of acquisition:Domestic

  • 細胞膜又はゴルジ体に局在する化合物及びその使用

    築地真也, 吉井達之, 中村彰伸, 沖超二, 鈴木祥央, 生田雅裕

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    Applicant:国立大学法人名古屋工業大学

    Application no:特願2019-038979  Date applied:2019.03

    Announcement no:特開2020-143049  Date announced:2020.09

    Country of applicant:Domestic   Country of acquisition:Domestic

Scientific Research Funds Acquisition Results

  • 個体内細胞操作を革新するin vivoケモジェネティクスツールの開発

    2022.06 - 2024.03

    科学研究費補助金  挑戦的研究(萌芽)

    築地真也

  • 超高感度バイオマーカー・ウイルス検出を実現する人工細胞センサーのボトムアップ構築

    2021.09 - 2026.03

    科学研究費補助金  学術変革領域研究(A)

    築地真也

  • 生細胞内メンブレンコンタクトの可視化・操作ツールの開発

    2021.04 - 2024.03

    科学研究費補助金  基盤研究(B)

    築地真也

  • 高汎用的な細胞内タンパク質阻害技術の開発

    2020.07 - 2022.03

    科学研究費補助金  挑戦的萌芽研究

    築地真也

  • 細胞内オルガネラ膜結合分子の拡張とin vivo展開

    2020.04 - 2021.09

    科学研究費補助金  新学術領域研究

    築地真也

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