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Affiliation Department |
生命・応用化学科 ソフトマテリアル分野
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TSUKIJI Shinya
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Research Areas
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Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules
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Nanotechnology/Materials / Chemical biology
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Nanotechnology/Materials / Bio chemistry
From School
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Kyushu University Faculty of Engineering Department of Chemical Science & Technology Graduated
- 1996.03
Country：Japan
From Graduate School
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Kyushu University Graduate School, Division of Engineering Department of Chemistry and Biochemistry Doctor's Course Completed
- 2001.03
Country：Japan
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Kyushu University Graduate School, Division of Engineering Department of Chemistry and Biochemistry Master's Course Completed
1996.04 - 1998.03
Country：Japan
External Career
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Nagoya University
2019.10
Country：Japan
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Nagoya University
2017.04 - 2017.09
Country：Japan
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Nagoya City University
2016.10 - 2017.03
Country：Japan
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Nagaoka University of Technology
2015.10 - 2016.03
Country：Japan
Papers
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Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters during collective cell migration of epithelial cells Reviewed International coauthorship
Eriko Deguchi, Shuhao Lin, Daiki Hirayama, Kimiya Matsuda, Akira Tanave, Kenta Sumiyama, Shinya Tsukiji, Tetsuhisa Otani, Mikio Furuse, Alexander Sorkin, Michiyuki Matsuda, Kenta Terai
Cell Reports 43 ( 11 ) 114986 2024.11
Language：English Publishing type：Research paper (scientific journal)
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γ-Secretase cleavages bifunctional fatty acid-conjugated small molecules with amide bonds in mammalian cells Reviewed
Kai Tahara, Akinobu Nakamura, Xiaotong Wang, Keishi Mitamura, Keiko Kano, Emi Mishiro-Sato, Yuki Ichihashi, Kazuhiro Aoki, Yasuteru Urano, Toru Komatsu, Shinya Tsukiji
ACS Chemical Biology in press 2024.11
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Acid-activatable photosensitizers for photodynamic therapy using self-aggregates of chlorophyll‒peptide conjugates Reviewed
Miyu Nagatani, Masaru Yoshikawa, Shinya Tsukiji, Masahiro Higuchi, Hitoshi Tamiaki, Shogo Matsubara
Polymer Journal in press 2024.09
Language：English Publishing type：Research paper (scientific journal)
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ORP9-PH domain-based fluorescent reporters for visualizing phosphatidylinositol 4-phosphate dynamics in living cells Reviewed
Moeka Ajiki, Masaru Yoshikawa, Tomoki Miyazaki, Asami Kawasaki, Kazuhiro Aoki, Fubito Nakatsu, Shinya Tsukiji
RSC Chemical Biology 5 544 - 555 2024.04
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Chemogenetic manipulation of endogenous proteins in fission yeast using a self-localizing ligand-induced protein translocation (SLIPT) system Reviewed
Akinobu Nakamura, Yuhei Goto, Hironori Sugiyama, Shinya Tsukiji, Kazuhiro Aoki
ACS Chemical Biology 18 ( 12 ) 2506 - 2515 2023.11
Language：English Publishing type：Research paper (scientific journal)
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Chemogenetic manipulation of endogenous proteins in fission yeast using a self-localizing ligand-induced protein translocation (SLIPT) system
Akinobu Nakamura, Yuhei Goto, Hironori Sugiyama, Shinya Tsukiji, Kazuhiro Aoki
bioRxiv 2023.07
Language：English Publishing type：Research paper (scientific journal)
DOI： https://doi.org/10.1101/2023.07.27.550911
Other Link： https://www.biorxiv.org/content/10.1101/2023.07.27.550911v2
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Hierarchical supramolecular structure comprising reduction-responsive DNA microspheres and semi-artificial glycopeptide-based micro-asters Reviewed
Ayaka Isogami, Sayuri L. Higashi, Bioru Okumura, Aya Shibata, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Shinya Tsukiji, Kazunori Matsuura, Masato Ikeda
Polymer Journal 55 1103 - 1107 2023.06
Language：English Publishing type：Research paper (scientific journal)
DOI： https://doi.org/10.1038/s41428-023-00809-1
Other Link： https://www.nature.com/articles/s41428-023-00809-1
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Revisit of the plasmon-mediated chemical transformation of para-aminothiophenol Reviewed
Toshiki Kondo, Motoharu Inagaki, Shohei Tanaka, Shinya Tsukiji, Kenta Motobayashi, Katsuyoshi Ikeda
Physical Chemistry Chemical Physics 25 14618 - 14626 2023.05
Language：English Publishing type：Research paper (scientific journal)
DOI： https://doi.org/10.1039/D3CP00924F
Other Link： https://pubs.rsc.org/en/content/articlelanding/2023/cp/d3cp00924f
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Palmitoylation-dependent small-molecule fluorescent probes for live-cell Golgi imaging Reviewed
Shunsuke Sawada, Masaru Yoshikawa, Keita Tsutsui, Tomoki Miyazaki, Keiko Kano, Emi Mishiro-Sato, Shinya Tsukiji
ACS Chemical Biology 18 1047 - 1053 2023.04
Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)
DOI： https://doi.org/10.1021/acschembio.3c00046
Other Link： https://pubs.acs.org/doi/10.1021/acschembio.3c00046
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Editorial overview: Synthetic biomolecules for probing lipid membranes International coauthorship
Neal K. Devaraj, Shinya Tsukiji
Current Opinion in Chemical Biology 73 102271 2023.02
Language：English Publishing type：Research paper (scientific journal)
DOI： https://doi.org/10.1016/j.cbpa.2023.102271
Other Link： https://www.sciencedirect.com/science/article/abs/pii/S1367593123000091
Misc
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細胞内シグナル分子の活性化を簡便・特異的・可逆的に誘導するSLIPT-PM法
築地真也
42 ( 11 ) 1750 - 1756 2024.06
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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細胞内シグナル分子を特異的に活性化する新ツール "SLIPT"
築地真也
74 ( 6 ) 595 - 601 2023.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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光-化学遺伝学による細胞内タンパク質の局在操作
吉井達之, 築地真也
16 ( 1 ) 7 - 9 2023.05
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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ケモジェネティクスによる細胞夾雑環境でのタンパク質活性操作
築地真也
Part II ( 9章 ) 86 - 92 2023.02
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
Other Link： https://www.kagakudojin.co.jp/book/b615061.html
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SLIPT-PMシステムを用いた細胞内シグナル操作
築地真也, 鈴木祥央
75 ( 12 ) 879 2022.11
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
Other Link： https://www.chemistry.or.jp/division-topics/2022/11/slipt-pm.html
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タンパク質活性を隔離・放出する人工相分離ドロップレット
築地真也, 吉川優
32 ( 3 ) 140 - 144 2022.08
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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メンブレンコンタクトの化学遺伝学操作を介した膜脂質代謝の可逆制御
吉川優, 阿喰萌香, 中津史, 築地真也
36 ( 2 ) 30 - 31 2021.12
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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細胞内相分離を理解・操作・活用する人工相分離ツール
築地真也, 吉川優
39 204 - 210 2021.06
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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局在性リガンドによる細胞夾雑空間でのタンパク質局在操作
築地真也
53 58 - 62 2021.04
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
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生命現象の操作と可視化のための細胞内人工相分離ツール
吉川優, 吉井達之, 築地真也
98 ( 5 ) 246 - 250 2020
Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
Presentations
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Chemogenetic control of protein localization with synthetic self-localizing ligands Invited International conference
Shinya Tsukiji
17th International Symposium on Nanomedicine (ISNM2024)
Event date： 2024.12
Language：English Presentation type：Oral presentation (invited, special)
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Design, synthesis, and evaluation of membrane-localizable gefitinib derivatives targeting an EGFR mutant International conference
Keishi Mitamura, Keita Tsutsui, Yoko Fukaya, Shinya Tsukiji
17th International Symposium on Nanomedicine (ISNM2024)
Event date： 2024.12
Language：English Presentation type：Poster presentation
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Targeted delivery of small molecules and peptides to the inner plasma membrane using a novel lipopeptidomimetic motif International conference
Xiaotong Wang, Shunsuke Sawada, Masaru Yoshikawa, Tomome Iijima, Keita Tsutsui, Shinya Tsukiji
17th International Symposium on Nanomedicine (ISNM2024)
Event date： 2024.12
Language：English Presentation type：Poster presentation
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In vitro selection of a small molecule-binding tag protein for fluorescence imaging International conference
Tomoki Miyazaki, Shun Umemoto, Koushirou Endo, Masaaki Tsuduki, Natsumi Fukaya, Kim Nguyen Chung, Tatsuyuki Yoshii, Yoshikatsu Sato, Tomoshige Fujino, Gosuke Hayashi, Tomoya Hino, Hiroshi Murakami, and Shinya Tsukiji
17th International Symposium on Nanomedicine (ISNM2024)
Event date： 2024.12
Language：English Presentation type：Poster presentation
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Synthetic self-localizing ligands for targeted protein relocalization Invited International conference
Shinya Tsukiji
4th Switzerland-Japan Biomolecular Chemistry Symposium (SJBC2024)
Event date： 2024.11
Language：English Presentation type：Oral presentation (invited, special)
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Chemogenetic control of membrane contacts and lipid transfer using lipid-conjugated small molecules International conference
Xiaotong Wang, Masaru Yoshikawa, Asami Kawasaki, Keita Tsutsui, Moeka Ajiki, Francesca Giordano, Kazuhiro Aoki, Fubito Nakatsu, Shinya Tsukiji
4th Switzerland-Japan biomolecular Chemistry Symposium (SJBCS2024)
Event date： 2024.11
Language：English Presentation type：Poster presentation
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A small self-labeling tag protein for fluorescence imaging International conference
Tomoki Miyazaki, Shun Umemoto, Koushirou Endo, Masaaki Tsuduki, Natsumi Fukaya, Kim Nguyen Chung, Tatsuyuki Yoshii, Yoshikatsu Sato, Tomoshige Fujino, Gosuke Hayashi, Tomoya Hino, Hiroshi Murakami, and Shinya Tsukiji
4th Switzerland-Japan biomolecular Chemistry Symposium (SJBCS2024)
Event date： 2024.11
Language：English Presentation type：Poster presentation
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Synthetic Activation of Epidermal Growth Factor Receptor (EGFR) through Plasma Membrane Recruitment International conference
Shuya Ohira, Kai Tahara, Masaru Yoshikawa, Shinya Tsukiji
4th Switzerland-Japan biomolecular Chemistry Symposium (SJBCS2024)
Event date： 2024.11
Language：English Presentation type：Poster presentation
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Artificial cells that sense biomarker enzymes International conference
Keita Tsutsui, Masaru Yoshikawa, Tomoaki Matsuura, Shinya Tsukiji
4th Switzerland-Japan biomolecular Chemistry Symposium (SJBCS2024)
Event date： 2024.11
Language：English Presentation type：Poster presentation
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小分子結合性モノボディタグの創製と蛍光イメージングへの展開
宮崎友輝、梅本駿、遠藤鴻志郎、都築成晃、深谷菜摘、Chung Nguyen Kim、吉井達之、佐藤良勝、藤野公茂、林剛介、日野智也、村上裕、築地真也
第55回中部化学関係協会支部連盟秋季大会
Event date： 2024.11
Language：Japanese Presentation type：Oral presentation (general)
Industrial Property Rights
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細胞膜非透過性の物質を動物細胞の細胞質に送達する新規キャリア分子
築地真也, 澤田隼佑
Applicant：国立大学法人名古屋工業大学
Application no：特開2022-029516 Date applied：2022.02
Country of applicant：Domestic Country of acquisition：Domestic
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フィブロネクチンIII型ドメイン骨格を含むポリペプチド
村上裕, 都築成晃, 近藤太志, 林剛介, 藤野公茂, 築地真也, 吉井達之
Applicant：国立大学法人東海国立大学機構, 国立大学法人名古屋工業大学
Application no：特願2020-145463 Date applied：2020.08
Announcement no：WO 2022/045365 A1 Date announced：2022.03
Country of applicant：Domestic Country of acquisition：Domestic
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ゴルジ体に局在する化合物及びその使用
築地真也, 中村彰伸, 澤田隼佑, 吉井達之
Applicant：国立大学法人名古屋工業大学
Application no：特願2020-141893 Date applied：2020.08
Announcement no：特開2022-37654 Date announced：2022.03
Country of applicant：Domestic Country of acquisition：Domestic
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細胞膜又はゴルジ体に局在する化合物及びその使用
築地真也, 吉井達之, 中村彰伸, 沖超二, 鈴木祥央, 生田雅裕
Applicant：国立大学法人名古屋工業大学
Application no：特願2019-038979 Date applied：2019.03
Announcement no：特開2020-143049 Date announced：2020.09
Patent/Registration no：特許第7478412号 Date registered：2024.04
Country of applicant：Domestic Country of acquisition：Domestic
Scientific Research Funds Acquisition Results
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細胞内時空間ダイナミクス解析を革新するオルガネラ膜局在性分子ツール
2024.04 - 2027.03
科学研究費補助金 基盤研究（B）
築地真也
Authorship：Principal investigator
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個体内細胞操作を革新するin vivoケモジェネティクスツールの開発
2022.06 - 2024.03
科学研究費補助金 挑戦的研究（萌芽）
築地真也
Authorship：Principal investigator
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超高感度バイオマーカー・ウイルス検出を実現する人工細胞センサーのボトムアップ構築
2021.09 - 2026.03
科学研究費補助金 学術変革領域研究(A)
築地真也
Authorship：Principal investigator
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生細胞内メンブレンコンタクトの可視化・操作ツールの開発
2021.04 - 2024.03
科学研究費補助金 基盤研究(B)
築地真也
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高汎用的な細胞内タンパク質阻害技術の開発
2020.07 - 2022.03
科学研究費補助金 挑戦的萌芽研究
築地真也