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Affiliation Department |
生命・応用化学科 生命・物質化学分野
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YAMAMURA Hatsuo
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Degree
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Master of Pharmaceutical Scinece ( Kyushu University )
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Doctor (Pharmaceutical Scinece) ( Nagasaki University )
Research Areas
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Life Science / Pharmaceutical chemistry and drug development sciences
From School
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Kyushu University Faculty of Pharmaceutical Science Graduated
- 1984.03
Country：Japan
From Graduate School
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Kyushu University Graduate School, Division of Pharmaceutical Sciences Master's Course Completed
- 1986.03
Country：Japan
Professional Memberships
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日本油化学会
2009.04
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日本化学会
2009.04
Research Career
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Chemistry of Natural and Modified Cyclodextrin
(not selected)
Project Year：
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Synthetic Studies of Carbohydrates and Analysis of Its Property
(not selected)
Project Year：
Papers
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Amphiphilic cyclodextrin derivatives with antibacterial activity: chemical mutation and structure-activity relationship Reviewed
Hatsuo Yamamura, Ayame Kato, Eri Yamada, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Kayo Osawa, and Atsushi Miyagawa
New Journal of Chemistry 48 12355 - 12361 2024.07
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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安全で抗菌性に優れた新規オリゴ糖誘導体—防腐効果のある化粧品原料の開発— Reviewed
小見宏幸，髙田健太，竹内彩乃，村上栞菜，宮川 淳，山村初雄
日本香粧品学会誌 48 ( 2 ) 82 - 88 2024.06
Authorship：Last author, Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)
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One-step synthesis of sugar nucleotides under optimized conditions Reviewed
Kota Fujihara, Hatsuo Yamamura and Atsushi Miyagawa
Synthetic communications 54 ( 15 ) 1245 - 1251 2024.05
Language：English Publishing type：Research paper (scientific journal)
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Facile synthesis of β-1,3-glucan disaccharides using acyl protected glycosyl donors and acceptors prepared from 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose Invited Reviewed
Atsushi Miyagawa, Ryusuke Tomita, Hatsuo Yamamura
24 ( 10 ) 69 - 78 2024.05
Authorship：Last author Language：English
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Atsushi Miyagawa, Nami Yamamoto, Ayane Ohno, Hatsuo Yamamura
International Journal of Biological Macromolecules 264 130546 2024.03
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
Other Link： https://www.sciencedirect.com/science/article/abs/pii/S0141813024013497
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Synthesis of cyclodextrin dimers via Diels–Alder reaction Reviewed
A. Miyagawa , T. Hasegawa, H. Yamamura
Synthetic Ccmmunications 53 ( 22 ) 1878 - 1885 2023.10
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Anti-bacterial ß-cyclodextrin derivatives inspired by the anti-microbial peptide polymyxin in order to better understand the role of single hydrophobic chain tail in selective anti-bacterial activity Reviewed
New Journal of Chemistry 47 10921 - 10929 2023.04
Authorship：Lead author, Corresponding author Language：English Publishing type：Research paper (scientific journal)
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Identification of a tomato UDP-arabinosyltransferase for airborne volatile reception Reviewed
K. Sugimoto, E. Ono, T. Inaba, T. Tsukahara, K. Matsui, M. Horikawa, H. Toyonaga, K. Fujikawa, T. Osawa, S. Homma, Y. Kiriiwa, Ippei Ohmura, Atsushi Miyagawa, Hatsuo Yamamura, M. Fujii, R. Ozawa, B.Watanabe, K. Miura, H. Ezura, T. Ohnishi, J. Takabayashi
Nature Communications 14 677 2023.02
Language：English Publishing type：Research paper (scientific journal)
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Synthesis of antimicrobial polymers with mannose residues for binding to the FimH adhesin of Escherichia coli Reviewed
Atsushi Miyagawa, Shinya Ohno, Hatsuo Yamamura
Journal of Polymer Science 2022.12
Authorship：Last author Language：English
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UDP glucose, cereblon dependent proinsulin degrader Reviewed
Cho, J.; Miyagawa, A.; Yamaguchi, K.; Abe, W.; Tsugawa, Y.; Yamamura, H.; Imai, T.
Scientific Reports 11 24516 2022.08
Language：English Publishing type：Research paper (scientific journal)
Misc
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ペプチドのバイオミメティクスとしてのシクロデキストリン誘導体による抗菌物質創製 Invited
山村 初雄
27 A19 2024.10
Authorship：Lead author, Corresponding author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Other Link： https://doi.org/10.32285/glycoforum.27A19J
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Cyclodextrin Derivatives as Biomimetics of Peptides for Creating Antimicrobial Substances Invited
Hatsuo Yamamura
Glycoforum 27 A19 2024.10
Authorship：Lead author, Corresponding author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
Other Link： https://doi.org/10.32285/glycoforum.27A19
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N,n-bis(Hexyl α-d-acetylmannosyl) acrylamide
Atsushi Miyagawa, Shinya Ohno, Hatsuo Yamamura
MolBank 2021 ( 3 ) 2021
Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：MDPI AG
Glycosyl monomers for the assembly of multivalent ligands are typically synthesized using carbohydrates with biological functions and polymerizable functional groups such as acrylamide or styrene introduced into the carbohydrate aglycon, and monomers polymerized using a radical initiator. Herein, we report the acryloylation of 6-aminohexyl α-mannoside and its conversion into the glycosyl monomer bearing an acrylamide group. The general acryloylation procedure afforded the desired N-hexyl acetylmannosyl acrylamide monomer as well as an unexpected compound with a close Rf value. The compounds were separated and analyzed by nuclear magnetic resonance spectroscopy and mass spectrometry, which revealed the unknown compound to be the bivalent N,N-bis(hexyl α-D-acetylmannosyl) acrylamide monomer, which contains two hexyl mannose units and one acrylamide group. To the best of our knowledge, this side reaction has not previously been disclosed, and may be useful for the construction of multivalent sugar ligands.
DOI： 10.3390/M1255
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Chemical Modification of Cyclodextrin and Amylose by Click Reaction and Its Application to Synthesis of Poly-alkylamine-modified Antibacterial Sugars Invited Reviewed International journal
Hatsuo Yamamura
65 ( 4 ) 312 - 317 2017.04
Authorship：Lead author Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
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Chemical Modification of Cyclodextrin and Amylose by Click Reaction and Its Application to the Synthesis of Poly-alkylamine-Modified Antibacterial Sugars Invited Reviewed
Hatsuo Yamamura
CHEMICAL & PHARMACEUTICAL BULLETIN 65 ( 4 ) 312 - 317 2017.04
Language：English Publishing type：Book review, literature introduction, etc. Publisher：PHARMACEUTICAL SOC JAPAN
Cyclodextrin (CD) can be chemically modified into desired and sophisticated functional molecules. However, poly-modification often produces complicated mixtures, resulting in a low yield of the desired product. As the most promising procedure to solve such problems and to achieve poly-modification of the CD molecule, we present here the Huisgen 1,3-dipolar cycloaddition, known as a click reaction. This review will describe the results of our microwave-assisted click reaction for the poly-modification of CD and amylose molecules, and its application to the study of synthetic membrane active antibacterial derivatives.
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Synthetic beta-1,3-Oligoglucans as Probes to Study for Hydrolysis and Recognition of Endo-beta-1,3-Glucanase
Atsushi Miyagawa, Masayuki Oda, Hatsuo Yamamura
GLYCOBIOLOGY 24 ( 11 ) 1132 - 1132 2014.11
Language：English Publishing type：Research paper, summary (international conference) Publisher：OXFORD UNIV PRESS INC
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Comprehensive syntheses of sialyl galactoside regioisomers
Kenta Kurimoto, Hatsuo Yamamura, Atsushi Miyagawa
GLYCOBIOLOGY 24 ( 11 ) 1140 - 1140 2014.11
Language：English Publishing type：Research paper, summary (international conference) Publisher：OXFORD UNIV PRESS INC
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Crystal structures of protected derivatives of alpha-alkoxyglycines
M Kawai, K Hosoda, Y Omori, H Yamamura, Y Miwa, T Taga
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 76 ( 11 ) 2215 - 2216 2003.11
Language：English Publisher：CHEMICAL SOC JAPAN
X-ray crysal structures of two alpha-alkoxyglycine derivatives, Cbz-Gly(OR)-OR (R = Me and Pr-i), were determined. The structural and chemical characteristics of Gly(OR) residues as unique beta-oxa analogs of alpha-amino acids are discussed.
DOI： 10.1246/bcsj.76.2215
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Complexation and chiral recognition thermodynamics of gamma-cyclodextrin with dipeptides possessing two aromatic rings.
MV Rekharsky, H Yamamura, S Araki, M Kawai, Y Inoue
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 225 U257 - U257 2003.03
Language：English Publishing type：Research paper, summary (international conference) Publisher：AMER CHEMICAL SOC
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Phosphodiester bond cleavage mediated by a cyclic beta-sheet peptide-based dinuclear zinc(II) complex (pg 1315, 2000)
K Yamada, Y Takahashi, H Yamamura, S Araki, K Saito, M Kawai
CHEMICAL COMMUNICATIONS ( 21 ) 2173 - 2173 2000
Presentations
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クリックケミストリーによる抗菌シクロデキストリン誘導体の合成と機能に関する研究 Invited
山村初雄
第３９回シクロデキストリンシンポジウム 2023.09
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保護基を用いない糖ヌクレオチドの合成
藤原 亘汰、山村 初雄、宮川 淳
第55回 中部化学関係学協会支部連合秋季大会 2024.11
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1,2-trans-O-グリコシド結合をもつ糖ヌクレオチドの一段階合成
藤原亘汰、山村初雄、宮川淳
日本農芸化学会 中部支部第199回例会 2024.09
Event date： 2024.09
Presentation type：Poster presentation
Venue：愛知県
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一段階反応による種々の糖ヌクレオチドの合成
藤原 亘汰、山村 初雄、宮川淳
糖鎖科学中部拠点 第20回「若手の力」フォーラム 2024.09
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β-グルカンオリゴ糖を基盤としたFRET 分子の合 成と endo-β -1,3- Glucanaseの検 出 能評価
宮川 淳，大野 綾音，金野 克博，山村 初雄
第43 回日本糖質学会年会 2024.09
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β-グルカンオリゴ糖を集積化したβ-グルカン模倣高分子の合成とその活性評価
宮川淳、山本菜未、大野綾音、山村初雄
日本化学会 第104春季年会 2024.03 日本化学会
Event date： 2024.03
Language：Japanese Presentation type：Oral presentation (general)
Venue：千葉県
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疎水性の調節により高い抗菌性を目指した２種類のアルキルアミノ基を持つシクロクロデキストリン誘導体
山村初雄、早野匠真、宮川淳
第３９回シクロデキストリンシンポジウム 2023.09
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β-グルカン模倣高分子ライブラリー構築とDectin-1の親和性と免疫活性化の相関研究
宮川淳、山本菜未、大野綾音、山村初雄
第４２回糖質学会年会 2023.09
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無保護糖を用いた糖ヌクレオチド一段階合成法の収率改善
藤原亘汰、神川早希、山村初雄、宮川淳
第４２回糖質学会年会 2023.09
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グロボ３糖を導入した抗菌ポリマーの合成と抗菌性評価
宮川 淳、寺島 萌乃、山村 初雄
第４２回糖質学会年会 2023.09
Industrial Property Rights
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菌体膜傷害性・抗菌性物質とその利用法
山村初雄,川井正雄,勝孝
Patent/Registration no：特許第5098015号 Date registered：2013.10 Date issued：2013.10
Country of applicant：Domestic Country of acquisition：Domestic
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Monoclonal antibody to human hemoglobin and its use for detection of occult blood
Application no：昭６３―２７３４７２
Country of applicant：Domestic Country of acquisition：Domestic
Awards
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Award for the Young Cyclodextrin Scientist, The Society of Cyclodextrins, Japan
2001.04
Country：Japan
Scientific Research Funds Acquisition Results
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Synthetic Studies of Carbohydrates and Analysis of Its Property
Grant type：Competitive
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Chemistry of Natural and Modified Cyclodextrin
Grant type：Competitive