Details of a Researcher - UJIHARA Yoshihiro

Papers - UJIHARA Yoshihiro

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Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure Reviewed International journal

Yoshihiro Ujihara, Motoi Kanagawa, Satoshi Mohri, Satomi Takatsu, Kazuhiro Kobayashi, Tatsushi Toda, Keiji Naruse, Yuki Katanosaka

Nature Communications 10 1 - 17 2019.12

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41467-019-13623-2

Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodeling Reviewed International journal

Ujihara Y, Iwasaki K, Takatsu S, Hashimoto K, Naruse K, Mohri S, Katanosaka Y

Cardiovascular Research 111 ( 4 ) 348 - 361 2016.09

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1093/cvr/cvw113

Proposed spring network cell model based on a minimum energy concept Reviewed International journal

Ujihara Y, Nakamura M, Miyazaki H, Wada S

Annals of Biomedical Engineering 38 ( 4 ) 1539 - 1538 2010.04

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s10439-010-9930-8

TRPV2 mediates stress resilience in mouse cardiomyocytes Reviewed

Yubing Dong, Guohao Wang, Yoshihiro Ujihara, Chen Yanzu, Kenji Yoshida, Kazufumi Nakamura, Kimiaki Katanosaka, Keiji Naruse, Yuki Katanosaka 2025.05

Language：English Publishing type：Research paper (scientific journal)

Empirical Estimation of Young’s Modulus for Biological Tissue Mimics Using Acoustic Impedance Measurements: A Study on Agar Gel Tissue Phantoms Reviewed

Morodomi S, Ito K, Maegawa S, Ujihara Y, Sugita S, Nakamura M

PloS one 20 ( 4 ) e0320705 2025.04

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0320705

Interleaflet Translocation of Second-Harmonic-Generation-Active Dye Molecules in Phospholipid Bilayers with Transmembrane Pores Reviewed

41 ( 5 ) 3209 - 3219 2025.02

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1021/acs.langmuir.4c03943

Relationships among capillary refill time, peripheral blood flow rate, and fingertip temperature: advances in peripheral artery contractility diagnosis Reviewed International journal

Sorataro Shibata, Yoshihiro Ujihara, Masanori Nakamura, and Shukei Sugita

Journal of Biomechanical Engineering 147 ( 2 ) 021005 2025.02

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1115/1.4067209

Phenotypic Plasticity of Vascular Smooth Muscle Cells in Aortic Dissection: Insights from Ex Vivo Flow Exposure Studies Reviewed International journal

Iwata S, Ujihara Y, Sugita S, Nakamura M

Journal of Biorheology 39 2024.12

Language：English Publishing type：Research paper (scientific journal)

Probing mechanical properties through acoustic impedance in cultured smooth muscle cells with cytoskeletal disruption using scanning acoustic microscopy Reviewed International journal

Yoshihiro Ujihara, Shota Watanabe, Shinri Morodomi, Shukei Sugita, Masanori Nakamura

Journal of Biorheology 39 2024.12

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Impact of habitat on ventricular stiffness in anurans: insights from Xenopus borealis and Buergeria buergeri Reviewed

Megumi Ito, Shukei Sugita, Masanori Nakamura, Yoshihiro Ujihara

Journal of Biorheology 38 ( 2 ) 65 - 72 2024.12

Language：English Publishing type：Research paper (scientific journal)

DOI： https://doi.org/10.17106/jbr.38.65

Stress Fiber Strain is Zero in Normal Aortic Smooth Muscle, Elevated in Hypertensive Stretch, and Minimal in Wall Thickening Rats Reviewed

14 29731 2024.11

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-024-81229-w

Other Link： https://www.nature.com/articles/s41598-024-81229-w?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20241129&utm_content=10.1038/s41598-024-81229-w#citeas

Finite element analysis and computational fluid dynamics to elucidate the mechanism of distal stent graft-induced new entry after frozen elephant trunk technique Reviewed International journal

Morodomi S, Okamura H, Ujihara Y, Sugita S, Nakamura M

European Journal of Cardio-Thoracic Surgery 2024.10

Language：English Publishing type：Research paper (scientific journal)

Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics Reviewed International journal

Ken Hashimoto, Momoko Ohira, Aya Kodama, Misaki Kimoto, Mariko Inoue, Shigenobu Toné, Yuu Usui, Akira Hanashima, Takato Goto, Yuhei Ogura, Yoshihiro Ujihara, Satoshi Mohri

Scientific Reports 14 ( 1 ) 13727 2024.06

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-024-64608-1

Mathematical modeling and experimental analysis of the relationship between ventricular size and diastolic function of trabecular ventricles Reviewed International journal

Megumi Ito, Yoshihiro Ujihara, Shukei Sugita, Masanori Nakamura

37 ( 2 ) 96 - 104 2023.11

Language：English Publishing type：Research paper (scientific journal)

Comparison of changes in Ca2+ concentration in quail and rat cardiomyocytes using Fura-4F Reviewed International journal

Yuhei Ogura, Shukei Sugita, Masanori Nakamura, Yoshihiro Ujihara

37 ( 2 ) 138 - 144 2023.11

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Longitudinal study of the mechanical properties of rat abdominal aortas incubated in ex vivo conditions Reviewed International journal

Sugita S, Kawai H, Ujihara Y, Nakamura M

Journal of Biorheology 37 ( 2 ) 36 - 43 2023.11

Language：English Publishing type：Research paper (scientific journal)

Nuclear deformability of cancer cells with different metastatic potential Reviewed

Yoshihiro Ujihara, Daichi Ono, Megumi Ito, Shukei Sugita, Masanori Nakamura

Journal of Biorheology 37 ( 2 ) 56 - 63 2023.11

Authorship：Lead author

Second harmonic generation signal imaging of the membrane damage due to electroporation Reviewed

Nakamura M, Takagi R, Wada H, Sinoda Y, Ujihara Y, Sugita S, Shigematsu T

Journal of Biorheology 37 ( 2 ) 145 - 154 2023.11

Effect of elastin on delamination strength in the porcine aortic tunica media Reviewed International journal

G. Kurihara, Y. Ujihara, M. Nakamura, and S. Sugita

Journal of Biorheology 37 ( 2 ) 120 - 129 2023.11

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Delamination strength and elastin interlaminar fibers decrease with the development of aortic dissection in model rats Reviewed International journal

G. Kurihara, Y. Ujihara, M. Nakamura, and S. Sugita

Bioengineering 10 ( 11 ) 1292 2023.11

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3390/bioengineering10111292

Other Link： https://www.mdpi.com/2306-5354/10/11/1292

Improvement in the precision of capillary refill time measurements for diagnosing hypovolemic status Reviewed International journal

Sugita S, Mizuno T, Ujihara Y, Nakamura M

Journal of Biomechanical Science and Engineering 18 ( 3 ) 23-00002 2023.07

Language：English Publishing type：Research paper (scientific journal)

Other Link： https://www.jstage.jst.go.jp/article/jbse/18/3/18_23-00002/_article/-char/en

Hamster Sperm Possess Functional Na+/Ca2+-Exchanger 1: Its Implication in Hyperactivation Reviewed International journal

Gen L. Takei , Yuhei Ogura, Yoshihiro Ujihara, Fubito Toyama, Keitaro Hayashi, Tomoe Fujita

International Journal of Molecular Sciences 24 ( 10 ) 8905 2023.05

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3390/ijms24108905

Decoding the effect of hydrostatic pressure on TRPV1 lower gate conformation by molecular dynamics simulation Reviewed International coauthorship International journal

Muhammad Harith Bin Zamri, Yoshihiro Ujihara, Masanori Nakamura, Mohammad R.K. Mofrad, and Shukei Sugita

International Journal of Molecular Sciences 23 ( 13 ) 7366 2022.07

Language：English Publishing type：Research paper (scientific journal)

Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15 Reviewed International journal

Ken Hashimoto, Aya Kodama, Momoko Ohira, Misaki Kimoto, Reiko Nakagawa, Yuu Usui, Yoshihiro Ujihara, Akira Hanashima, Satoshi Mohri

iScience 2022.05

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.isci.2022.104337

Direct visualization of interstitial flow distribution in aortic walls Reviewed International journal

Wataru Fukui, Yoshihiro Ujihara, Masanori Nakamura, and Shukei Sugita

Scientific Reports 12 5381 2022.03

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-022-09304-8

Other Link： https://www.nature.com/articles/s41598-022-09304-8

Decrease in Ca2+ Concentration in Quail Cardiomyocytes Is Faster than That in Rat Cardiomyocytes Reviewed International journal

Yuhei Ogura, Hioroaki Ito, Shukei Sugita, Masanori Nakamura, Yoshihiro Ujihara

Processes 10 ( 3 ) 508 2022.03

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.3390/pr10030508

Differences in Pressure Resistance and Tissue Structure of Ventricles between Aquatic, Semiaquatic, and Terrestrial Anura Reviewed

59 ( 6 ) 162 - 168 2021.12

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.11239/jsmbe.59.162

Comparison of the histology and stiffness of ventricles in Anura of different habitats Reviewed International journal

Megumi Ito, Yoshihiro Ujihara, Shukei Sugita, Masanori Nakamura

Journal of Biological Physics 2021.09

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s10867-021-09579-4

Novel method for clarifying faster interstitial flow in the intimal side of the aorta under intraluminal pressurization

Fukui W, Ujihara Y, Nakamura M, Sugita S

bioRxiv 2021.07

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1101/2021.07.09.451753

Second harmonic generation light quantifies the ratio of type III to total (I + III) collagen in a bundle of collagen fiber Reviewed International journal

Shukei Sugita, Takuya Suzumura, Akinobu Nakamura, Shinya Tsukiji, Yoshihiro Ujihara, and Masanori Nakamura

Scientific Reports 11 ( 1 ) 11874 2021.06

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-021-91302-3

Other Link： https://www.nature.com/articles/s41598-021-91302-3

B16 Melanoma Cancer Cells with Higher Metastatic Potential are More Deformable at a Whole-Cell Level Reviewed International journal

Yoshihiro Ujihara, Daichi Ono, Koki Nishitsuji, Megumi Ito, Shukei Sugita, Masanori, Nakamura

Cellular and Molecular Bioengineering 2021.05

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s12195-021-00677-w

Stress fibers of the aortic smooth muscle cells in tissues do not align with the principal strain direction during intraluminal pressurization Reviewed International journal

Shukei Sugita, Naoto Mizuno, Yoshihiro Ujihara, and Masanori Nakamura

Biomechanics and Modeling in Mechanobiology 20 1003 - 1011 2021.01

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s10237-021-01427-7

Other Link： https://link.springer.com/article/10.1007%2Fs10237-021-01427-7

Transient induction of cell cycle promoter Fam64a improves cardiac function through regulating Klf15-dependent cardiomyocyte differentiation in mice International journal

Ken Hashimoto, Aya Kodama, Momoko Ohira, Misaki Kimoto, Reiko Nakagawa, Yuu Usui, Yoshihiro Ujihara, Akira Hanashima, Satoshi Mohri

bioRxiv 2021.01

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1101/2021.04.01.438048

Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice Reviewed

Michio Sato, Keishi Miyata, Zhe Tian, Tsuyoshi Kadomatsu, Yoshihiro Ujihara, Jun Morinaga, Haruki Horiguchi, Motoyoshi Endo, Jiabin Zhao, Shunshun Zhu, Taichi Sugizaki, Kimihiro Igata, Masashi Muramatsu, Takashi Minami, Takashi Ito, Marco E Bianchi, Satoshi Mohri, Kimi Araki, Koichi Node, Yuichi Oike

Circulation Journal 83 ( 2 ) 368 - 378 2019.01

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1253/circj.CJ-18-0925

Nuclear connectin novex-3 promotes proliferation of hypoxic foetal cardiomyocytes Reviewed International journal

Hashimoto K, Kodama A, Sugino M, Yobimoto T, Honda T, Hanashima A, Ujihara Y, Mohri S

Scientific Reports ８ 12337 2018.08

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-018-30886-9

Turtle spongious ventricles exhibit more compliant diastolic property and possess larger elastic regions of connectin in comparison to rat compact left ventricles Reviewed International journal

Honda T, Ujihara Y, Hanashima A, Hashimoto K, Tanemoto K, Mohri S

Kawasaki Medical Journal 44 ( 1 ) 1 - 17 2018

Language：English Publishing type：Research paper (scientific journal)

Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice Reviewed International journal

Hashimoto K, Kodama A, Honda T, Hanashima A, Ujihara Y, Murayama T, Nishimatsu S, Mohri S

Scientific Reports 7 4486 2017.06

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-017-04823-1

Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle Reviewed International journal

Hanashima A, Hashimoto K, Ujihara Y, Yobimoto T, Kodama A, Mohri S

Gene 59 19 - 26 2017.01

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.gene.2016.10.010

赤血球膜破断強度計測を目的とした赤血球引張試験 Reviewed

中村匡徳, 池田拓郎, 氏原嘉洋

実験力学 16 ( 4 ) 301 - 306 2016.12

Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.11395/jjsem.16.301

Effects of induced Na+/Ca2+ exchanger overexpression on the spatial distribution of L-type Ca2+ channels and junctophilin-2 in pressure-overloaded hearts Reviewed International journal

Ujihara Y, Mohri S, Katanosaka Y

Biochemical and Biophysical Research Communications 480 ( 4 ) 564 - 569 2016.11

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bbrc.2016.10.090

ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism Reviewed International journal

Tian Z, Miyata K, Kadomatsu T, Horiguchi H, Fukushima H, Tohyama S, Ujihara Y, Okumura T, Yamaguchi S, Zhao J, Endo M, Morinaga J, Sato M, Sugizaki T, Zhu S, Terada K, Sakaguchi H, Komohara Y, Takeya M, Takeda N, Araki K, Manabe I, Fukuda K, Otsu K, Wada J, Murohara T, Mohri S, Yamashita JK, Sano M, Oike Y

Nature Communications 7 13016 2016.09

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/ncomms13016

Numerical simulations of tensile tests of red blood cells: effects of the hold position Reviewed International journal

Nakamura M, Ujihara Y

Micro and Nanosystems 7 ( 3 ) 41 - 55 2015.08

Language：English Publishing type：Research paper (scientific journal)

Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans Reviewed International journal

Wei F, Zhou B, Suzuki T, Miyata K, Ujihara Y, Horiguchi H, Takahashi N, Xie P, Michiue H, Fujimura A, Kaitsuka T, Matsui H, Koga Y, Mohri S, Suzuki T, Oike Y, Tomizawa K

Cell Metabolism 21 ( 2 ) 428 - 442 2015.03

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.cmet.2015.01.019

Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments Reviewed International journal

Ujihara Y, Nakamura M, Soga M, Koshiyama K, Miyazaki H, Wada S

Computers in Biology and Medicine 56 20 - 29 2015.01

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.compbiomed.2014.10.015

Left ventricular mechanics and myocardial calcium dynamics in short-term and long-term hyperthyroid mice Reviewed International journal

Sasae Y, Hashimoto K, Ujihara Y, Hanashima A, Honda T, Morita Y, Mohri S

Kawasaki Medical Journal 41 ( 2 ) 41 - 55 2015

Language：English Publishing type：Research paper (scientific journal)

Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells Reviewed International journal

Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, Takuwa Y, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I

Pharmacology & Pharmaceutical Medicine 2 ( 5 ) e00068 2014.10

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/prp2.68

TRPV2 is critical for the maintenance of cardiac structure and function in mice Reviewed International journal

Katanosaka Y, Iwasaki K, Ujihara Y, Takatsu S, Nishitsuji K, Kanagawa M, Sudo A, Toda T, Katanosaka K, Mohri S, Naruse K

Nature Communications 5 3932 2014.05

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/ncomms4932

Segmentation and morphometric analysis of cells from fluorescence microscopy images of cytoskeletons Reviewed International journal

Ujihara Y, Nakamura M, Miyazaki H, Wada S

Computational and Mathematical Methods in Medicine 2013 381356 2013

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Contribution of actin filaments to the global compressive properties of fibroblasts Reviewed International journal

Ujihara Y, Nakamura M, Miyazaki H, Wada S

Journal of the Mechanical Behavior of Biomedical Materials 14 192 - 198 2012.10

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.jmbbm.2012.05.006

Effects of cytoskeletal orientations on deformation of a cell residing in a collagen gel construct Reviewed International journal

Nakamura M, Ujihara Y, Soga M, Koshiyama K, Miyazaki H, Wada S

Journal of Biomechanical Science and Engineering 7 ( 1 ) 2 - 14 2012

Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1299/jbse.7.2

Effects of the initial tension in actin fibers on the global tensile and compressive properties of a cell Reviewed International journal

Ujihara Y, Nakamura M, Miyazaki H, Wada S

Transactions of the Japanese Society for Medical and Biological Engineering 48 ( 6 ) 604 - 608 2010.12

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.11239/jsmbe.48.604

Effects of the initial orientation of actin fibers on global tensile properties of cells Reviewed International journal

Ujihara Y, Nakamura M, Miyazaki H, Wada S

Journal of Biomechanical Science and Engineering 5 ( 5 ) 515 - 525 2010

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1299/jbse.5.515

Morphological study of fibroblasts treated with cytochalasin D and colchicine using a confocal laser scanning microscopy Reviewed International journal

Ujihara Y, Miyazaki H, Wada S

The Journal of Physiological Sciences 58 ( 7 ) 499 - 506 2008.12

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2170/physiolsci.RP007708

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Papers - UJIHARA Yoshihiro