論文 - 山村 初雄
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Amphiphilic cyclodextrin derivatives with antibacterial activity: chemical mutation and structure-activity relationship 査読あり
Hatsuo Yamamura, Ayame Kato, Eri Yamada, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Kayo Osawa, and Atsushi Miyagawa
New Journal of Chemistry 48 12355 - 12361 2024年07月
担当区分：筆頭著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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安全で抗菌性に優れた新規オリゴ糖誘導体—防腐効果のある化粧品原料の開発— 査読あり
小見宏幸，髙田健太，竹内彩乃，村上栞菜，宮川 淳，山村初雄
日本香粧品学会誌 48 ( 2 ) 82 - 88 2024年06月
担当区分：最終著者, 責任著者 記述言語：日本語 掲載種別：研究論文（学術雑誌）
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One-step synthesis of sugar nucleotides under optimized conditions 査読あり
Kota Fujihara, Hatsuo Yamamura and Atsushi Miyagawa
Synthetic communications 54 ( 15 ) 1245 - 1251 2024年05月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Facile synthesis of β-1,3-glucan disaccharides using acyl protected glycosyl donors and acceptors prepared from 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 招待あり 査読あり
Atsushi Miyagawa, Ryusuke Tomita, Hatsuo Yamamura
24 ( 10 ) 69 - 78 2024年05月
担当区分：最終著者 記述言語：英語
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Atsushi Miyagawa, Nami Yamamoto, Ayane Ohno, Hatsuo Yamamura
International Journal of Biological Macromolecules 264 130546 2024年03月
担当区分：最終著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
その他リンク： https://www.sciencedirect.com/science/article/abs/pii/S0141813024013497
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Synthesis of cyclodextrin dimers via Diels–Alder reaction 査読あり
A. Miyagawa , T. Hasegawa, H. Yamamura
Synthetic Ccmmunications 53 ( 22 ) 1878 - 1885 2023年10月
担当区分：最終著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Anti-bacterial ß-cyclodextrin derivatives inspired by the anti-microbial peptide polymyxin in order to better understand the role of single hydrophobic chain tail in selective anti-bacterial activity 査読あり
New Journal of Chemistry 47 10921 - 10929 2023年04月
担当区分：筆頭著者, 責任著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Identification of a tomato UDP-arabinosyltransferase for airborne volatile reception 査読あり
K. Sugimoto, E. Ono, T. Inaba, T. Tsukahara, K. Matsui, M. Horikawa, H. Toyonaga, K. Fujikawa, T. Osawa, S. Homma, Y. Kiriiwa, Ippei Ohmura, Atsushi Miyagawa, Hatsuo Yamamura, M. Fujii, R. Ozawa, B.Watanabe, K. Miura, H. Ezura, T. Ohnishi, J. Takabayashi
Nature Communications 14 677 2023年02月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Synthesis of antimicrobial polymers with mannose residues for binding to the FimH adhesin of Escherichia coli 査読あり
Atsushi Miyagawa, Shinya Ohno, Hatsuo Yamamura
Journal of Polymer Science 2022年12月
担当区分：最終著者 記述言語：英語
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UDP glucose, cereblon dependent proinsulin degrader 査読あり
Cho, J.; Miyagawa, A.; Yamaguchi, K.; Abe, W.; Tsugawa, Y.; Yamamura, H.; Imai, T.
Scientific Reports 11 24516 2022年08月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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UDP-glucose: A cereblon-dependent glucokinase Protein Degrader 査読あり
Cho, J.; Miyagawa, A.; Yamaguchi, K.; Abe, W.; Tsugawa, Y.; Yamamura, H.; Imai, T.
Int. J. Mol. Sci. 23 9094 2022年04月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Antimicrobial activities of amphiphilic cationic polymers and their efficacy of combination with novobiocin 査読あり
Miyagawa, A., Ohno, S., Hattori, T., Yamamura, H.
Journal of Biomaterials Science, Polymer Edition 22 299 - 312 2022年02月
担当区分：最終著者 掲載種別：研究論文（学術雑誌）
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Antibacterial Activity of Membrane-Permeabilizing Bactericidal Cyclodextrin Derivatives 査読あり
Hatsuo Yamamura, Tatsuya Hagiwara, Yuma Hayashi, Kayo Osawa, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Ayumi Sumino, Hayato Yamashita, Ryo Jinno, Masayuki Abe, Atsushi Miyagawa
ACS Omega 6 ( 47 ) 31831 - 31842 2021年11月
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Antibacterial Activity of Membrane-permeabilizing Bactericidal Cyclodextrin Derivatives 査読あり 国際誌
Hatsuo Yamamura, Tatsuya Hagiwara, Yuma Hayashi, Kayo Osawa, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Ayumi Sumino, Hayato Yamashita, Ryo Jinno, Masayuki Abe, Atsushi Miyagawa
ACS Omega 2021年11月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
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Antimicrobial activities of amphiphilic cationic polymers and their efficacy of combination with novobiocin 査読あり 国際誌
Miyagawa, A., Ohno, S., Hattori, T., Yamamura, H
Journal of Biomaterials Science, Polymer Edition 2021年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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N, N-Bis (hexyl α-d-acetylmannosyl) Acrylamide 査読あり 国際誌
Atsushi Miyagawa, Shinya Ohno, Hatsuo Yamamura
Molbank 2021 ( 3 ) M1255 2021年07月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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One-Step Synthesis of Sugar Nucleotides 査読あり 国際誌
Atsushi Miyagawa, Sanami Toyama, Ippei Ohmura, Shun Miyazaki, Takeru Kamiya, Hatsuo Yamamura
J. Org. Chem. 85 15645 - 15651 2020年11月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Synthesis of β-1,3-glucan mimics by β-1,3-glucan trisaccharyl monomer polymerization 査読あり 国際誌
Atsushi Miyagawa, Hatsuo Yamamura
Carbohydrate Polymers 227 115105 2020年01月
記述言語：英語 掲載種別：研究論文（学術雑誌）
β-1,3-Glucans are important as immunostimulating agents in living organisms. The multivalent binding ofβ-1,3glucans to dectin-1, a cell surface receptor, activates immunological defenses. To study artificial immunostimulating agents, glycopolymers carrying β-1,3-glucan trisaccharides as artificial ligands were synthesized. The β-1,3-glucan trisaccharide, defined as an active unit of β-1,3-glucan, was constructed from D-glucose by glycosylation. A norbornene group was introduced as a polymerizable group into the trisaccharide derivative at the aglycone. The prepared endo/exo norbornene stereoisomers of the monomers were separated by silica gel chromatography and identified by NMR spectroscopy and mass spectrometry. The synthesized glycosyl monomers were polymerized and copolymerized with norbornene using 2nd generation Hoveyda-Grubbs catalyst, deprotected, and purified by gel filtration to prepare water-soluble glycopolymers of varied compositions and high molecular weights. These polymers will have the potential for multivalent binding to dectin-1 to activate immune response and facilitate studies to understand the binding mechanisms of β-1,3-glucans with dectin-1.
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Gramicidin S-inspired Antimicrobial Cyclodextrin to Disrupt Gram-negative and Gram-positive Bacterial Membranes 査読あり 国際誌
Hatsuo Yamamura, Kana Isshiki, Yusuke Fujita, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Kayo Osawa, Atsushi Miyagawa
MedChemComm 10 ( 10 ) 1432 - 1437 2019年08月
担当区分：筆頭著者 記述言語：英語 掲載種別：研究論文（学術雑誌）
A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-O-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.
DOI： 10.1039/C9MD00229D
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Development of New Antimicrobial Agents from Cationic PG-surfactants containing oligo-Lys peptides 査読あり
Kimura Ryosuke, Shibata Masahide, Koeda Shuhei, Miyagawa Atsushi, Yamamura Hatsuo Mizuno Toshihisa
Bioconjugate Chemistry 2018年12月
記述言語：英語 掲載種別：研究論文（学術雑誌）
Peptide gemini-surfactant (PG-surfactant), a kind of lipopeptide, is composed of a short linker peptide (X) between two alkyl-chain-modified Cys residues, and peripheral peptides at the N-terminal (Y) and the C-terminal (Z) sides, respectively, of the alkylated
Cys residues. In this study, we developed and examined a series of PG-surfactants containing two C12 saturated alkanes and oligo-Lys, arranged at the X-, Y-, or Z-positions. To arrange oligo-Lys at the Y- or Z-positions, a repeat sequence of -Asp-Lys-Asp-Lys-
was used at the X-position. All of the PG-surfactants exhibited high antimicrobial activity against both gram-positive and negative bacteria. In addition to high antimicrobial activity, a low hemolysis activity is prerequisite for efficient intravenous administration.
Among the synthesized PG-surfactants, those having -(Lys)3- at the Y- or Z-positions, i.e. K3-DKDKC12 and DKDKC12-K3, showed reasonably low hemolytic activities. This combination of high antimicrobial activity along with low hemolytic activity is an
essential and unique property, and has not been previously reported for the synthesized lipopeptides. Further, using scanning electron microscope (SEM) and N-phenyl-1-naphthylamine (NPN) uptake assay we showed that the antimicrobial activity of these PG-surfactants may be attributed to membrane disruptive mechanisms. Although the PG-surfactants with low hemolytic activity could interact and localize onto red blood cell surfaces, and cause slight expansion of cell morphologies, no subsequent penetration occurred. In summary, we describe here the successful development of PG-surfactants having high antibacterial and low hemolytic activity, thus providing a significant molecular platform to develop novel antimicrobial agents.
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