OHTANI Hajime

写真a

Affiliation Department etc.

Department of Life Science and Applied Chemistry
Department of Life Science and Applied Chemistry

Title

Professor

Mail Address

E-mail address

Degree

  • Nagoya University -  Doctor of Engineering

External Career

  • 1998.04
    -
    2005.03

    Associate Professor, Graduate School of Engineering, Nagoya University   Associate Professor (as old post name)  

  • 1995.04
    -
    1998.03

    Associate Professor, Center for Integrated Research in Science and Engineering   Associate Professor (as old post name)  

  • 1986.07
    -
    1995.03

    Assistant Professor, School of Engineering, Nagoya University   Research Assistant  

Academic Society Affiliations

  • 2014.03
    -
    Now

    The Society of Rubber Science and Technology, Japan

  • 2012.10
    -
    Now

    Tha Mass Specttrometry Society of Japan

  • 2002.06
    -
    2018.06

    American Chemical Society

  • 1998.04
    -
    Now

    Materials Life Society, Japan

  • 1992.05
    -
    Now

    The Japan Scientist Association

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Field of expertise (Grants-in-aid for Scientific Research classification)

  • Polymer chemistry

  • Analytical chemistry

 

Research Career

  • Study on Degradation and Modification of Polymeric Materials

    Collaboration in Japan   (not selected)  

    Project Year:  1986.01  -  Now

  • Basis and Application of Pyrolysis-Gas Chromatography

    International Collaboration   (not selected)  

    Project Year:  1980.04  -  Now

  • Structural Characterization of Polymers

    International Collaboration   (not selected)  

    Project Year:  1980.04  -  Now

Papers

  • Analysis of Multiply Charged Poly(Ethylene Oxide-co-Propylene Oxide) Using Electrospray Ionization-Ion Mobility Spectrometry-Mass Spectrometry

    Kanako ITO, Shinya KITAGAWA, Hajime OHTANI

    Analytical Sciences ( 日本分析化学会 )    2018.12  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Electrophoretic behavior in nonaqueous capillary zone electrophoresis using tetrahydrofuran-based ternary nonaqueous solutions

    Soichiro UCHIDA, Shinya KITAGAWA, Yoshinori IIGUNI, Hajime OHTANI

    Chromatography ( クロマトグラフィー科学会 )  39 ( 3 ) 161 - 165   2018.10  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    Nonaqueous capillary electrophoresis has the potential to separate water-insoluble analytes. Previously, we reported the separation of water-insoluble and neutral synthetic polymers in nonaqueous capillary zone electrophoresis using tetrahydrofuran (THF)-based ternary nonaqueous solutions. In this paper, the effect of the composition of a THF-based ternary solution (THF, acetonitrile, and methanol) containing cetyltrimethylammonium chloride (CTAC) on electrophoretic behavior is investigated using small organic compounds as prove analytes. In addition to general electrophoretic parameters such as electrophoretic mobility, analytical stability was also evaluated. The electric current, electrophoretic mobility of the benzyltriethylammonium cation (ion pair formation with chloride anion), and electrophoretic mobility of coronene (solvophobic interaction with the CTA cation) were dominated mainly by the THF content, and lower THF content resulted in higher values. In contrast, electroosmotic mobility was enhanced by an increase in THF content and was affected mainly by methanol content. Interestingly, in addition to stable electropherograms, we observed instable (fluctuation of baseline or zero current) electropherograms, which were obtained irregularly. Although a notable relation between the composition and the instable behavior was not observed, it is suggested that this “discontinuous instability” is related with the composition distribution (heterogeneous composition) of the ternary solvents in a capillary. Increasing the temperature effectively suppressed the composition distribution and has the potential to decrease the risk of instable behavior.

  • On the Kendrick mass defect plots of multiply charged polymer ions: splits, misalignments and how to correct them

    Thierry N. J. Fouque, Robert B. Cody, Yuka Ozeki, Shinya Kitagawa, Hajime Ohtani, Hiroaki Sato

    Journal of The American Society for Mass Spectrometry ( Springer )  29 ( 8 ) 1611 - 1626   2018.08  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    The Kendrick mass defect (KMD) analysis of multiply charged polymeric distributions has recently revealed a surprising isotopic split in their KMD plots—namely a 1/z difference between KMDs of isotopes of an oligomer at charge state z. Relying on the KMD analysis of actual and simulated distributions of poly(ethylene oxide) (PEO), the isotopic split is mathematically accounted for and found to go with an isotopic misalignment in certain cases. It is demonstrated that the divisibility (resp. indivisibility) of the nominal mass of the repeating unit (R) by z is the condition for homolog ions to line up horizontally (resp. misaligned obliquely) in a KMD plot. Computing KMDs using a fractional base unit R/z eventually corrects the misalignments for the associated charge state while using the least common multiple of all the charge states as the divisor realigns all the points at once. The isotopic split itself can be removed by using either a new charge-dependent KMD plot compatible with any fractional base unit or the remainders of KM (RKM) recently developed for low-resolution data all found to be linked in a unified theory. These original applications of the fractional base units and the RKM plots are of importance theoretically to satisfy the basics of a mass defect analysis and practically for a correct data handling of single stage and tandem mass spectra of multiply charged homo- and copolymers.

  • Micro-fin structured poly(butylene terephthalate) monolith prepared by thermally induced phase separation

    Yukiko Kajima, Shinya Kitagawa, Hajime Ohtani

    Chemistry Letters ( 日本化学会 )  47 ( 4 ) 417 - 420   2018.04  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    Poly(butylene terephthalate) (PBT) monoliths were prepared from a solution of linear PBT solution by cooling induced phase separation. The bicontinuous monoliths composed of globules having a micro-fin structure, and the monolith of such morphological feature, similar to nano flower, has never been reported in the literature. Both the size of the globule and the fin thickness could be controlled by the refrigeration temperature.

  • Separation of water-insoluble and neutral linear synthetic polymers in nonaqueous capillary zone electrophoresis using phosphonium-based ionic liquid

    Nao Fukai, Shinya Kitagawa, Hajime Ohtani

    Chromatography ( クロマトグラフィー科学会 )  38 ( 3 ) 123 - 127   2017.10  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    The separation of neutral and water-insoluble linear synthetic polymers in non-aqueous capillary zone electrophoresis using the hydrophobic phosphonium-based ionic liquid trihexyl(tetradecyl)phosphonium chloride (P66614Cl) were investigated using polystyrene, polymethylmethacrylates, polybutadiene, and polycarbonate as test analytes. The solubility of P66614Cl in tetrahydrofuran was above 500 mM, which was significantly higher than that of the general ionic surfactants used in our previous studies. The separation of the four polymers was achieved using a binary mixture of tetrahydrofuran/methanol or tetrahydrofuran/acetonitrile containing P66614Cl as the electrophoretic medium. It was confirmed that an increase in hydrophobicity or bulkiness of the cationic reagent improved the polymer separation. The interaction between polycarbonate with P66614Cl was reduced by the addition of acetonitrile, and enhanced by the methanol addition.

  • On-line analysis of catalytic reaction products using a high-pressure tandem micro-reactor GC/MS

    Atsushi WATANABE, Young-Min KIM, Akihiko HOSAKA, Chuichi WATANABE, Norio TERAMAE, Hajime OHTANI, Seungdo KIM, Young-Kwon PARK, Kaige WANG, Robert R. FREEMAN

    Analytical Sciences ( 公益社団法人日本分析化学会 )  33 ( 9 ) 1085 - 1089   2017.09  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    When a GC/MS system is coupled with a pressurized reactor, the separation efficiency and the retention time are directly affected by the reactor pressure. To keep the GC column flow rate constant irrespective of the reaction pressure, a restrictor capillary tube and an open split interface are attached between the GC injection port and the head of a GC separation column. The capability of the attached modules is demonstrated for the on-line GC/MS analysis of catalytic reaction products of a bio-oil model sample (guaiacol), produced under a pressure of 1 to 3 MPa.

  • Multi-imaging of cytokinin and abscisic acid on the roots of rice (oryza sativa) using matrix-assisted laser desorption/ionization mass spectrometry

    Katsuhiro Shiono, Riho Hashizaki, Toyofumi Nakanishi, Tatsuko Sakai, Takushi Yamamoto, Koretsugu Ogata, Ken-ichi Harada, Hajime Ohtani, Hajime Katano, Shu Taira

    Journal of Agricultural and Food Chemistry ( American Chemical Society )  65 ( 35 ) 7624 - 7628   2017.09  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    Plant hormones act as important signaling molecules that regulate responses to abiotic stress as well as plant growth and development. Because their concentrations of hormones control the physiological responses in the target tissue, it is important to know the distributions and concentrations in the tissues. However, it is difficult to determine the hormone concentration on the plant tissue as a result of the limitations of conventional methods. Here, we report the first multi-imaging of two plant hormones, one of cytokinin [i.e., trans-zeatin (tZ)] and abscisic acid (ABA) using a new technology, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI–TOF–MS) imaging. Protonated signals of tZ (m/z 220.1) and ABA (m/z 265.3) were chosen on longitudinal sections of rice roots for MS imaging. tZ was broadly distributed about 40 mm behind the root apex but was barely detectable at the apex, whereas ABA was mainly detected at the root apex. Multi-imaging using MALDI–TOF–MS enabled the visualization of the localization and quantification of plant hormones. Thus, this tool is applicable to a wide range of plant species growing under various environmental conditions.

  • High resolution Kendrick mass defect analysis of poly(ethylene oxide)-based non-ionic surfactants and their degradation products

    Thierry Fouquet, Haruo Shimada, Katsuyuki Maeno, Kanako Ito, Yuka Ozeki, Shinya Kitagawa, Hajime Ohtani, Hiroaki Sato

    Joulnal of Oleo Science ( Japan Oil Chemists' Society )  66 ( 9 ) 1061 - 1072   2017.09  [Refereed]

    Research paper (scientific journal)   Single Author

    Matrix assisted laser desorption ionization (MALDI) high-resolution mass spectrometry (HRMS) and the recently introduced high-resolution Kendrick mass defect (HRKMD) analysis are combined to thoroughly characterize non-ionic surfactants made of a poly(ethylene oxide) (PEO) core capped by esters of fatty acids. A PEO monostearate surfactant is first analyzed as a proof of principle of the HRKMD analysis conducted with a fraction of EO as the base unit (EO/X with X being an integer) in lieu of EO for a regular KMD analysis. Data visualization is greatly enhanced and the distributions detected in the MALDI mass spectrum are assigned to a pristine (H, OH)-PEO as well as mono- and di-esterified PEO chains with palmitate and stearate end-groups in HRKMD plots computed with EO/45. The MALDI-HRMS/HRKMD analysis is then successfully applied to the more complex case of ethoxylated hydrogenated castor oil (EHCO) found to contain a large number of hydrogenated ricinoleate moieties (up to 14) in its HRKMD plot computed with EO/43, departing from the expected triglyceride structure. The exhaustiveness of the MALDI-HRMS/HRKMD strategy is validated by comparing the so-obtained fingerprints with results from alternative techniques (electrospray ionization MS, size exclusion and liquid adsorption chromatography, ion mobility spectrometry). Finally, aged non-ionic surfactants formed upon hydrolytic degradation are analyzed by MALDI-HRMS/HRKMD to easily assign the degradation products and infer the associated degradation routes. In addition to the hydrolysis of the ester groups observed for EHCO, chain scissions and new polar end-groups are observed in the HRKMD plot of PEO monostearate arising from a competitive oxidative ageing.

  • Effect of surfactant species and electrophoretic medium composition on the electrophoretic behavior of neutral and water-insoluble linear synthetic polymers in nonaqueous capillary zone electrophoresis

    Nao Fukai, Shinya Kitagawa, Hajime Ohtani

    Electrophoresis ( Wiley )  38 ( 13-14 ) 1724 - 1729   2017.07  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    We have recently demonstrated the separation of neutral and water-insoluble linear synthetic polymers in nonaqueous capillary zone electrophoresis (NACZE) using a cationic surfactant of cetyltrimethylammonium chloride (CTAC). In this study, eight ionic surfactants were investigated for the separation of four synthetic polymers (polystyrene, polymethylmethacrylates, polybutadiene, and polycarbonate); only three surfactants (CTAC, dimethyldioctadecylammonium bromide, and sodium dodecylsulfate) caused their separation. The order of the interaction between the polymers and the surfactants depended on both the surfactant species and the composition of the electrophoretic medium. Their investigation revealed that the separation is majorly affected by the hydrophobic interactions between the polymers and the ionic surfactants. In addition, the electrophoretic behavior of polycarbonate suggested that electrostatic interaction also affects the selectivity of the polymers.

  • Retention in high-performance liquid chromatography at -196ºC

    Tomohiro Motono, Shinya Kitagawa, Hajime Ohtani

    Journal of Chromatography A ( Elsevier )  1503   32 - 37   2017.06  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    Recently, we have developed ultralow-temperature high-performance liquid chromatography (HPLC) at −196 °C using liquid nitrogen-based mobile phases. In this study, a retention model for ultralow-temperature HPLC, in which adsorption exchange and “pseudo partition” modes are combined, is proposed to describe the effect of the mobile phase composition on the retention of analytes. The experimental results agreed well with the equation of the proposed model. It was revealed that, in the low and high additive concentration regions, adsorption exchange and pseudo partition retention, respectively, dominate the analyte retention. The difference in the retention behavior between bare-silica and octadecylsilyl-modified silica (ODS) columns was also studied. Retention of alkanes in the ODS column was greater than that in the bare-silica one. Addition of both ethane and ethylene to the mobile phase in the ODS column afforded the elution of propylene, which was not eluted with the bare-silica column at −196 °C.

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Books

  • Practical Gas Chromatography

    Shin TSUGE, Hajime OHTANI (Part: Allotment Writing )

    Springer  2014.12 ISBN: 978-3-642-54640-2

  • Pyrolysis-GC/MS Data Book of Synthetic Polymers

    TSUGE Shin, OHTANI Hajime, WATANABE Chuichi (Part: Multiple Authorship )

    Elsevier  2011.10 ISBN: 978-0-444-53892-5

    This data book provides an extensive reference collection of the behavior of specific polymers during pyrolysis. It fills a big gap in the available standards and data on pyrolysis research, as there are no books that give the same combination of excellent analytical data with such a wide range of polymer systems that are useful to so many areas of multidisciplinary research. The data provided will be useful whenever a new polymer has to be analyzed in order to facilitate the identification or to confirm the results. The book also briefly reviews the instrumentation available in advanced analytical pyrolysis and offers guidance to perform this technique, effectively combining gas chromatography and mass spectrometry. Main contents are comprehensive sample pyrograms, thermograms, identification tables, and representative mass spectra (MS) of pyrolyzates for synthetic polymers. This edition also highlights thermally assisted hydrolysis and methylation techniques effectively applied to 33 basic condensation polymers.

  • Recent Trends of LED-UV Curing Technology and Curing Materials, "jointly worked"

    H. Ohtani (Part: Multiple Authorship )

    CMC Publishing  2010.05 ISBN: 978-4-7813-0221-8

  • Introduction to Polymer Analysis, "jointly works"

    H. Ohtani (Part: Multiple Authorship )

    2010.04 ISBN: 978-4-06-154360-7

  • Conservation of Paper and Books

    H. Ohtnai (Part: Multiple Authorship )

    Iwata-shoin  2009.10 ISBN: 978-4-87294-574-4

  • Crosslinking and Degradation of Polymers for Sustainable Chemistry

    H. Ohtani (Part: Multiple Authorship )

    CMC Publishing  2007.07 ISBN: 978-4-88231-693-0

  • The Fifth Series of Experimental Chemistry 20-1 Analytical Chemistry, "jointly worked"

    H. Ohtani (Part: Multiple Authorship )

    Maruzen  2007.01 ISBN: 978-4-621-07319-3

  • Applied Pyrolysis Handbook second edition, "jointly worked"

    H. Ohtani, S. Tsuge (Part: Multiple Authorship ,  4. Microstructure of Polyolefins, pp.65-80; 5. Degradation Mechanism of Condensation Polymers:Polyesters and Polyamides, pp.81-103;11. Characterization of Condensation Polymers by Pyrolysis-GC in the Presence of Organic Alkali, pp.249-269 )

    CRC Press  2007.01 ISBN: 1-57444-641-X

  • Pyrolysis GC/MS of Highpolymers - Fundamentals and Pyrograms -, "jointly worked"

    S. Tsuge, H. Ohtani, C. Watanabe (Part: Multiple Authorship )

    Technosystem  2006.10 ISBN: 4-924728-51-9

  • Analytical Chemistry, 6th edition, "jointry worked"

    H. Ohtani (Part: Joint Translation )

    Maruzen  2005.03 ISBN: 978-4-621-07554-8

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Review Papers

  • Rapid Evaluation of The Weatherrability of polymers bu Xenon Lamp-Based Online Ultraviolet Irradiation-Pyrolysis-GC/MS

    Science and Industry   88 ( 1 ) 19 - 27   2014.01

    Introduction and explanation (others)   Multiple Authorship

  • Evaluation of Acidic Paper Deterioration in Library Materials by Pyrolysis-Gas Chromatography

    Hajime Ohtani

    Senri Ethnological Studies ( 国立民族学博物館 )  85   11 - 19   2013.12

    Introduction and explanation (others)   Single Author

    Pyrolysis-gas chromatography (Py-GC) was used to evaluate deteriorated acidic paper in old books. A tiny piece (ca. 0.25 mg) of deteriorated paper from each book was subjected to Py-GC measurement at a 300 °C pyrolysis temperature. Levoglucosan and its dehydrated form levoglucosenone were typical degradation products, whereas primarily only levoglucosan was observed in control samples of undamaged new paper. The relative intensity of levoglucosenone was much higher in samples taken at the heavily deteriorated marginal edge than in those taken from the center of the same page of an old book. Accordingly, levoglucosenone observed in the pyrogram can be used as a marker to evaluate the degree of deterioration of acidic paper. The formation of levoglucosenone can be attributed to the slow deterioration process of paper, in which the dehydration reaction plays an important role, accompanied by the chain scission of cellulose. The Py-GC method for paper evaluation was also applied to clarify the effect of storage conditions on the deterioration of paper materials and to evaluate the long-term deterioration of the British Parliamentary Papers (1801–1986) collected at the Kyoto University Library.

  • Direct Analysis of Stabilizers in Plastic Materials by Pyrolysis-GC and MALDI-MS

      47 ( 10 ) 336 - 344   2012.10

    Introduction and explanation (international conference proceedings)   Single Author

  • Polymer Characterization by Mass Spectrometry

    OHTANI Hajime

    Journal of Network Polymer, Japan ( Japan Thermosetting Plastic Industry Association )  32 ( 4 ) 219 - 227   2011.07

    Introduction and explanation (international conference proceedings)   Single Author

  • Ongoing study on the conservation of paper and books: evaluating paper deterioration and strengthening of deteriorated paper

    H, Sonoda, M. Seki, T. Okayama, H. Ohtani

    International Preservation News ( The International Federation of Library Associations and Institutions )  48   27 - 29   2009.08

    Introduction and explanation (international conference proceedings)   Multiple Authorship

  • Structural Characterization of UV-cured Acrylic Ester Resins by Specific Sample Decomposition

    H. Ohtani

    Journal of Network Polymer, Japan ( Japan Thermosetting Plastics Industry Association )  30 ( 1 ) 23 - 32   2009.02

    Introduction and explanation (international conference proceedings)   Single Author

Presentations

  • End group analysis of poly(methyl methacrylate) using electrospray ionization-ion mobility-tandem mass spectrometry

    M. Omae, Y. Ozeki, S. Kitagawa, H. Ohtani

    RSC Tokyo International Conference 2018  (幕張メッセ)  2018.09  -  2018.09  日本分析化学会

  • Frequency division multiplex LC-MS for simultaneous analyses of plural samples

    H. Kishi, T. Kumazaki, S. Kitagawa, H. Ohtani

    RSC Tokyo International Conference 2018  (幕張メッセ)  2018.09  -  2018.09  日本分析化学会

  • Thermal decomposition reaction of cured phenol resin in hydrogen donor solvent studied by pyrolysis-GC-MS and MALDI-MS

    Hajime Ohtani, Ryota Kano

    The 10th International Conference of Modification, Degradation and Stabilization of Polymers  (東京大学)  2018.09  -  2018.09  MoDeSt組織委員会

  • Separation of Water-insoluble and Neutral Linear Synthetic Polymer in Non-aqueous Electrophoresis Using Ionic Surfactant

    S. Kitagawa, N. Fukai, S. Uchida, K. Usui, H. Ohtani

    25th International Symposium on Electro- and Liquid Phase-Separation Techniques (ITP2018)  (京都大学桂キャンパス)  2018.08  -  2018.09  ITP2018組織委員会

  • A Novel Multiplex LC-MS Based on Frequency Division Multiplexing for Simultaneous Analyses of Plural Samples

    H. Kishi, T. Kumazaki, S. Kitagawa, H. Ohtani

    25th International Symposium on Electro- and Liquid Phase-Separation Techniques (ITP2018)  (京都大学桂キャンパス)  2018.08  -  2018.09  ITP2018組織委員会

  • HPLC at ultralow-temperatures

    S. Kitagawa, T. Motono, H. Ohtani  [Invited]

    2018 Sino-Japanese Joint Symposium on Separation Sciences  (中国科学院大連化学物理研究所)  2018.07  -  2018.07  中国科学院大連化学物理研究所

  • Polymer Characterization by Pyrolysis Technique

    Hajime Ohtani  [Invited]

    2018 APAC Chemical Material Technology Summit  (Waters Corporation Headquarters/University of Liverpool)  2018.07  -  2018.07  Waters Corporation/University of Liverpool

  • Polymer characterization using pyrolysis-gas chromatography-atmospheric pressure chemical ionization quadrupole time-of-flight mass spectrometry

    K. Harata, H. Ohtani, T. Ezaki

    22nd International Symposium on Analytical & Applied Pyrolysis (PYRO2018)  (京都大学)  2018.06  -  2018.06  PYRO2018組織委員会

  • Catalytic co-pyrolysis of lignocellulosic biomass with polystyrene studied by tandem micro-reactor-GC system

    A. Hosaka, T. Muroi, C. Watanabe, S. Karagos, H. Ohtani

    22nd International Symposium on Analytical & Applied Pyrolysis (PYRO2018)  (京都大学)  2018.06  -  2018.06  PYRO2018組織委員会

  • Development of a new sampling device for Py-GC/MS analysis and its modification for solid phase extraction

    K. Tei, N. Teramae, H. Ohtani, T. Kaneko

    22nd International Symposium on Analytical & Applied Pyrolysis (PYRO2018)  (京都大学)  2018.06  -  2018.06  PYRO2018組織委員会

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Grant-in-Aid for Scientific Research

  • Applicability of Cellulose Nanofibers for the Conservation of Paper

    Grant-in-Aid for Scientific Research(B)

    Project Year: 2015.04  -  2018.03 

 
 

Academic Activity

  • 2018.03
    -
    Now

    The Chemical Society of Japan  

  • 2018.03
    -
    Now

    The Japan Society for Analytical Chemistry  

  • 2016.03
    -
    2017.02

    The Japan Society for Analytical Chemistry  

  • 2014.04
    -
    Now

    The Japan Society for Analytical Chemistry  

  • 2014.04
    -
    2015.03

    The Japan Society for Analytical Chemistry  

  • 2014.03
    -
    2016.02

    The Japan Society for Analytical Chemistry  

  • 2013.03
    -
    2014.02

    The Japan Society for Analytical Chemistry  

  • 2012.03
    -
    Now

    The Society of Polymer Sciences, Japan  

  • 2012.03
    -
    2013.02

    The Chemical Society of Japan  

  • 2011.03
    -
    2013.02

    The Japan Society for Analytical Chemistry  

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