MIZUNO Toshihisa

写真a

Affiliation Department etc.

Department of Life Science and Applied Chemistry
Department of Life Science and Applied Chemistry

Title

Associate Professor

Research Fields, Keywords

Biofunctional chemistry, Protein Engineering, Nano-materials

Graduating School

  •  
    -
    1995.03

    Nagoya Institute of Technology   Faculty of Engineering   Graduated

Degree

  • Kyushu University -  Doctor (Engineering)

  • Kyushu University -  Master (Engineering)

External Career

  • 2001.04
    -
    2002.03

      Researcher  

  • 1999.04
    -
    2001.03

      Special researcher of the Japan Society for the Promotion of Science  

Field of expertise (Grants-in-aid for Scientific Research classification)

  • Bio-related chemistry

 

Research Career

  • Rational design of the stimuli-respondent proteins

    Individual   Grant-in-Aid for Scientific Research  

    Project Year:  2004.04  -  2010.03

Papers

  • Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol

    Natsumi Sumito, Shuhei Koeda, Naoki Umezawa, Yasumichi Inoue, Shinya Tsukiji, Tsunehiko Higuchi, Toshihisa Mizuno

    Bioconjugate Chemistry   xx ( xx ) xx - xx   2020.01  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Development of New Antimicrobial Agents from Cationic PG-surfactants containing oligo-Lys peptide

    R. Kimura, M. Shibata, S. Koeda, A. Miyagawa, H. Yamamura, T. Mizuno

    Bioconjugate Chemistry   29 ( 12 )   2018.12  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Construction of Enzyme-encapsulated Fibermats from the Cross-linkable Copolymers Poly(acrylamide)-co-poly(diacetone acrylamide) with the Bi-functional Cross-linker, Adipic Acid Dihydrazide

    Yuya Ido, Anthony L. B. Maçon, Makito Iguchi, Yuto Ozeki, Shuhei Koeda, Akiko Obata, Toshihiro Kasuga, Toshihisa Mizuno

    Polymer   132   342 - 352   2017.12  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Design of New Extraction Surfactants for Membrane Proteins from Peptide-Gemini Surfactants (PG-surfactants)

    M. Shibata, S. Koeda, T. Noji, K. Kawakami, Y. Ido, Y. Amano, N. Umezawa, T. Higuchi, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno

    Bioconjugate Chemistry   27 ( 10 ) 2469 - 2479   2016.10

    Research paper (scientific journal)   Multiple Authorship

  • Coaxial Electrospun Fibermat of Poly(AM/DAAM)/ADH and PCL: Versatile Platform for Encapsulating Functionally Active Enzymes

    Yuji Tanikawa, Yuya Ido, Ren Ando, Akiko Obata, Kenji Nagata, Toshihiro Kasuga, Toshihisa Mizuno

    Bulletin of the Chemical Society of Japan   93   1155 - 1163   2020.06  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Construction of DNAzyme-Encapsulated Fibermats Using the Precursor Network Polymer of Poly(γ-glutamate) and 4-Glycidyloxypropyl Trimethoxysilane

    Koji Mizuno, Shuhei Koeda, Akiko Obata, Jun Sumaoka, Toshihiro Kasuga, Julian R. Jones, Toshihisa Mizuno

    Langmuir   33 ( 16 ) 4028 - 4035   2017.04  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Rational Design of Novel High-Molecular-Weight Solubilization Surfactants for Membrann Proteins from the peptide gemini surfactants (PG-surfactants)

    S. Koeda, T. Suzuki, T. Noji, K. Kawakami, Y. Ido, T. Dewa, S. Itoh, N. Kamiya, T. Mizuno

    Tetrahedron   72   6898 - 6908   2016.10  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Light-induced hydrogen production by Photosystem I–Pt nanoparticle conjugates immobilized in porous glass plate nanopores

    T. Noji, T. Suzuki, M. Kondo, T. Jin, K. Kawakami, T. Mizuno, H. Oh-oka, M. Ikeuchi, M. Nango, Y. Amao, N. Kamiya, T. Dewa

    Res. Chem. Intermed   42 ( 0 ) 7731 - 7742   2016.09  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Construction and Characterization of Protein-Encapsulated Electrospun Fibermats Prepared from a Silica/Poly(γ-glutamate) Hybrid

    S. Koeda, K. Ichiki, N. Iwanaga, K. Mizuno, M. Shibata, A. Obata, T. Kasuga, T. Mizuno

    Langmuir   32 ( 1 ) 221 - 229   2015.12  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Applications of Peptide Gemini Surfactants as Solubilization Surfactants for Photosystems I and II of Cyanobacteria

    Shuhei Koeda, Katsunari Umezaki, Tomoyasu Noji, Atsushi Ikeda, Keisuke Kawakami, Masaharu Kondo, Yasushi Yamamoto, Jian-Ren Shen, Keijiro Taga, Takehisa Dewa, Mamoru Nango, Toshiki Tanaka, Toshihisa Mizuno

    Langmuir   29 ( 37 ) 11667 - 11680   2013.09  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

display all >>

Review Papers

  • Construction of the Artificial Proteins Whose Functions Can Be Altered with the Specific External Inputs by Using the Engineered Protein Modules

    Toshihisa Mizuno, Masayuki Oda, Toshiki Tanaka

    NetsuSokutei ( The Japan Society of Calorimetry and Thermal Analysis )  35 ( 5 ) 227 - 236   2008.10

    Introduction and explanation (international conference proceedings)   Multiple Authorship

Presentations

  • Construction of Protein-loadable Protein Cages Using the Hybrid Proteins of the Oleosin Hydrophobic Domain and Hydrophilic Dimeric Coiled-coil

    T. Nishiyama, K. Sugiura, K. Takahashi, T. Mizuno  [Invited]

    ISNM2021  2021.11  -  2021.11 

  • Evaluation of enzymatic activity of the enzyme-encapsulated core-shell fibermats of nylon-6/poly (AA/DAAM)

    Taira Ishiguro, Toshihisa Mizuno

    4th GLowing Polymer Symposium in KANTO (GPS-K 2021)  2021.07  -  2021.07 

  • Development of the PG-surfactants, functioning as a cell-type-selective membrane permeation carrier

    Momoka Yamada, Natsumi Sumito, Naoki Umezawa, Yasumichi Inoue, Toshihisa Mizuno

    4th GLowing Polymer Symposium in KANTO (GPS-K 2021)  2021.07  -  2021.07 

  • Coaxial Electrospun Fibermat of Poly(AM/DAAM)/ADH and PCL: Versatile Platform for Functioning Active Enzymes

    Yuji Tanikawa, Yuya Ido, Akiko Obata, Toshihiro Kasuga, Toshihisa Mizuno

    3rd GLowing Polymer Symposium in KANTO (GPS-K 2020)  2020.11  -  2020.11 

  • Construction of Protein-loadable Protein Cages Using the Hybrid Proteins of the Oleosin Hydrophobic Domain and Hydrophilic Dimeric Coiled-coil

    Taiki Nishiyama, Kento Sugiura, Toshihisa Mizuno

    3rd GLowing Polymer Symposium in KANTO (GPS-K 2020)  2020.11  -  2020.11 

  • 抗体結合蛋白質を有した蛋白質カプセルの抗体結合能評価

    西山 泰貴、水野 稔久

    第30回バイオ・高分子シンポジウム  2020.07  -  2020.07 

  • Development of cell-penetration PG-surfactants and its application in external peptide delivery to cytosol

    Natsumi Sumito, Shuhei Koeda, Naoki Umezawa, Yasumichi Inoue, Shinya Tsukiji, Tsunehiko Higuchi, Toshihisa Mizuno  [Invited]

    ISNM2019  2019.12  -  2019.12 

  • Development of peptide gemini surfactants as carriers for intracellular transport of foreign substances

    Natsumi Sumito, Naoki Umezawa, Shinya Tsukiji, Toshihisa Mizuno

    ISNM2019  2019.12  -  2019.12 

  • Solubilization properties of the polyacrylamide-conjugated PG-surfactants for membrane proteins

    Taro Shimamoto, Keisuke Kawakami, Nobuo Kamiya, Toshihisa Mizuno

    ISNM2019  2019.12  -  2019.12 

  • 外来ペプチドの細胞内への輸送キャリヤーとして働く新規ペプチドジェミニ型界面活性剤の設計と評価

    住藤 夏美, 築地 真也, 水野 稔久

    第68回高分子学会年次大会  2019.05  -  2019.05 

display all >>