NAKAMURA Shuichi

写真a

Affiliation Department etc.

Department of Life Science and Applied Chemistry
Department of Life Science and Applied Chemistry

Title

Professor

Mail Address

E-mail address

Research Fields, Keywords

Asymmetric synthesis, Optically active compounds, chiral, Synthesis of biologically active compounds

Graduating School

  •  
    -
    1996.03

    Nagoya Institute of Technology   Faculty of Engineering   Graduated

Graduate School

  •  
    -
    2001.03

    Nagoya Institute of Technology  Graduate School, Division of Engineering  Doctor's Course  Completed

  •  
    -
    1998.03

    Nagoya Institute of Technology  Graduate School, Division of Engineering  Doctor's Course  Completed

Degree

  • Nagoya Institute of Technology -  Doctor (Engineering)

  • Nagoya Institute of Technology -  Master (Engineering)

External Career

  • 2003.09
    -
    2004.08

      Researcher  

Academic Society Affiliations

  • 1996.04
    -
    Now

    The Chemical Society of Japan

  • 2008.04
    -
    Now

    American Chemical Society

  • 1997.04
    -
    Now

    The Society of Synthetic Organic Chemistry

  • 2009.04
    -
    Now

    The Japanese Society for Process Chemistry

Field of expertise (Grants-in-aid for Scientific Research classification)

  • Organic chemistry

  • Synthetic chemistry

  • Drug development chemistry

  • Bio-related chemistry

  • Green/Environmental chemistry

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Research Career

  • Development of environmental friendly asymmetric synthesis

    (not selected)  

    Project Year:  2005.04  -  Now

  • Development of Novel Asymmetric Catalysts

    Grant-in-Aid for Scientific Research  

    Project Year:  2002.04  -  Now

  • Development of Novel Asymmetric Syntheses using sulfur compounds

    Grant-in-Aid for Scientific Research  

    Project Year:  2000.04  -  Now

  • Stereoselective reaction of α-heterocarbanion

    Grant-in-Aid for Scientific Research  

    Project Year:  2000.04  -  2008.04

Papers

  • Catalytic enantioselective decarboxylative nucleophilic addition reactions using chiral organocatalysts

    Kengo Hyodo, Shuichi Nakamura

    Organic & Biomolecular Chemistry ( RSC )    2020.03  [Refereed]  [Invited]

    Research paper (scientific journal)   Multiple Authorship

    有機触媒を用いる脱炭酸型不斉求核付加反応の総合論文

  • Enantioselective Vinylogous Mannich Reaction of Acyclic Vinylketene Silyl Acetals with Ketimines Using Chiral Bis(imidazoline)-Cu(II) Catalysts

    Shuichi Nakamura,* Koichi Matsuzaka, Tsubasa Hatanaka, Yasuhiro Funahashi

    Organic Letters ( ACS )    2020.02  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    直鎖系ビニルケテンシリルアセタールを用いるケチミン類への世界初のビニロガスMannich反応に成功した。また、皿に共役系を伸ばした求核剤をもちいビスビニロガスMannich反応の開発にも成功した

  • Enantioselective conjugate addition of an a,a-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)-Pd complexes

    Shuichi Nakamura,* Akari Tokunaga, Hikari Saito, Masaru Kondo

    Chemical Communications ( RSC )  55 ( 37 ) 5391 - 5394   2019.04  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    ジチオアセトニトリルの共役付加反応を世界で初めて可能としました。合成した化合物から、医薬品の有効成分であるロリプラム(抗炎症剤:選択的ホスホジエステラーゼ阻害薬)へと変換も行いました。

  • Enantioselective Reaction of 2H-Azirines

    Shuichi Nakamura*

    Chemistry An Asian Journal ( RSC )  14 ( 9 ) 1323 - 1330   2019.04  [Refereed]

    Research paper (scientific journal)   Single Author

    アジリンの不斉反応について取りまとめた

  • Enantioselective Aza-Friedel-Crafts Reaction of Cyclic Ketimines with Indoles Using Chiral Imidazoline-Phosphoric Acid Catalysts

    Shuichi Nakamura*, Takashi Furukawa, Tsubasa Hatanaka, Yasuhiro Funahashi

    Chemical Communications ( RSC )  54 ( 31 ) 3811 - 3814   2018.05  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    環状のケチミンにインドール類を反応させるaza-Friedel-Crafts型反応の初めての例で、当研究室で開発した不斉イミダゾリン-リン酸触媒を用いることで成功した。

  • Catalytic Enantioselective Reaction of 2H-Azirines with Thiols Using Cinchona Alkaloid Sulfonamide Catalysts

    Shuichi Nakamura*, Daiki Hayama, Masataka Miura, Tsubasa Hatanaka, Yasuhiro Funahashi

    Organic Letters     2018.01  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    アジリン類へのチオールの付加による光学活性N,S-アセタールの合成を検討した。不斉触媒として、これまでに当研究室で開発したシンコナアルカロイド-キノリンスルホンアミド触媒を利用したところ、高立体選択的に反応が進行することが明らかとなった。

  • Catalytic Enantioselective Reaction of Allenylnitriles with Imines Using Chiral Bis(imidazoline)s-Palladium(II) Pincer Complexes

    Masaru Kondo, Masashi Omori, Tsubasa Hatanaka, Yasuhiro Funahashi, Shuichi Nakamura

    Angew. Chem. Int. Ed.   56 ( 30 ) 8677 - 8680   2017.06  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    独自に開発した不斉パラジウム触媒を用いることで、これまでに不斉合成反応において利用することができなかったアレニルニトリル類のイミン類への反応の開発に成功しました。合成した化合物群は、生物活性物質の合成中間体として利用が可能です。

  • Enantioselective Reaction of 2H-Azirines with Phosphite Using Chiral Bis(imidazoline)/Zinc(II) Catalysts

    Shuichi Nakamura,* Daiki Hayama

    Angew. Chem. Int. Ed.   56 ( 30 ) 8785 - 8789   2017.05  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    今回、独自に開発した不斉ビスイミダゾリン触媒を用いることで、これまでに不斉合成反応において、ほとんど利用されてこなかったアジリン類への高立体選択的不斉求核付加反応の開発に世界で初めて成功しました。

  • Direct catalytic enantioselective Mannich-type reaction of a,a-dithioacetonitriles with imines using chiral bis(imidazoline)-Pd complexes

    Masaru Kondo, Hikari Saito, Shuichi Nakamura*

    Chemical Communications ( RSC )  53 ( 0 ) 6776 - 6779   2017.04  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    a,a-ジチオアセトニトリルを用いるイミン類への不斉求核付加反応の開発に成功した。触媒として、当研究室で開発しているビスイミダゾリン-Pd触媒を用いたところ、高立体選択的に反応が進行することが明らかとなった。また、ジチオ部分、ニトリル基部分の合成的変換にも成功した。

  • Enantioselective Barbier-type Allylation of Ketones Using Allyl halide and Indium in Water

    Shuichi Nakamura, Yoshichika Hara, Takashi Furukawa, Tsunehisa Hirashita

    RSC Advances   7 ( 25 ) 15582 - 15585   2017.03  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    近年、環境調和型溶媒として、水が注目されている。そこで、ケトンへの水中での不斉アリル化反応を検討した。触媒として、当研究室で開発したt-ブチルカルボニル基を導入したイミダゾリン触媒を用い、藩王を検討したところ、比較的、高立体選択的に反応が進行することが明らかとなった。

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Books

  • The Chemistry of Pincer Compounds; Chapter 10. Chiral NCN pincer-type catalysts having bis(imidazoline)s

    Kengo Hyodo, Shuichi Nakamura (Part: Multiple Authorship )

    ELSEVIER  2018.05 ISBN: 978-0-12-812931-9

  • Organosulfur Chemistry in Asymmetric Synthesis, Asymmetric Reaction of a-Sulfenyl Carbanions

    (Part: Multiple Authorship )

    Wiley  2008.04 ISBN: 3527318542

  • Science of Synthesis, Compounds with Two Carbon-Heteroatom Bonds, Volume 31a Arene-X (X = Hal, O, S, Se, Te). Aryl sulfones and N Derivatives (31.10)

    (Part: Multiple Authorship )

    Thime  2007.04

  • Science of Synthesis, Compounds with Two Carbon-Heteroatom Bonds, Volume 31a Arene-X (X = Hal, O, S, Se, Te). Arenesulfinic Acids and Derivatives (31.11)

    (Part: Multiple Authorship )

    Thime  2007.04

  • Organolithiums in Enantioselective Synthesis (Topics in Organometallic Chemistry) Enantioselective Synthesis by Lithiation Adjacent to S, Se or P, or Without an Adjacent Activating Heteroatom

    (Part: Multiple Authorship )

    Springer  2003.04 ISBN: 3540001042

Review Papers

  • E-factor

      10 ( 68 ) 1082 - 1082   2010.10

    Introduction and explanation (scientific journal)   Single Author

Presentations

  • Asymmetric Propargylation of ketones using chiral bis(imidazoline) catalysts on water

    Wakana Suzuki, Shuichi Nakamura

    The 3rd FRIMS International Symposium on Frontier Materials  (名工大)  2019.11  -  2019.11  FRIMS

  • Enantioselective Vinylogous Mannich Reaction of Ketimines Using Chiral Bis(imidazoline)-Copper(II) Catalyst

    Koichi Matsuzaka, Shuichi Nakamura

    The 3rd FRIMS International Symposium on Frontier Materials  (名工大)  2019.11  -  2019.11  FRIMS

  • Development of Organocatalytic Stereoselective Decarboxylative Aldol Reaction ofα-Amido Malonic Acid Half Oxyesters to Isatins

    Kazuki Abe, Jumpei Yokoi, Shuichi Nakamura

    The 3rd FRIMS International Symposium on Frontier Materials  (名工大)  2019.11  -  2019.11  FRIMS

  • Asymmetric Synthesis of Chiral Aziridines through the Reaction of Oxazolones to 2H-Azirine

    Masataka Miura, Nakamura Shuich

    The 3rd FRIMS International Symposium on Frontier Materials  (名工大)  2019.11  -  2019.11  FRIMS

  • Enantioselective Synthesis of Chiral Amines Having tetra-Substituted Carbon Centers Using Novel Chiral Catalysts (具有四取代碳中心的手性胺的不对称合成 使用新型手性催化剂)

    Shuichi Nakamura  [Invited]

    The 8th Japanese-Sino Symposium on Organic Chemistry for Young Scientists  (Kyoto Garden Palace)  2019.09  -  2019.09  Organizing comitte for The 8th Japanese-Sino Symposium on Organic Chemistry for Young Scientists

  • Enantioselective Construction of tetra-Substituted Carbon Centers Using Novel Chiral Catalysts

    Shuichi Nakamura  [Invited]

    Meeting for Institute of Scientific and Industrial Research  (Osaka University)  2019.05  -  2019.05  Osaka University

  • Development of new asymmetric reactions of 2H-azirines with phosphorus nucleophiles by using novel chiral catalysts

    Daiki Hayama, Shuichi Nakamura

    2nd FRIMS International Symposium on Frontier Materials  (Nagoya Institute of Technology)  2018.02  -  2018.02  FRIMS

  • Enantioselective aza-Friedel-Crafts reaction of cyclic ketimines with indole using novel phosphoric acid catalysts

    Takashi Furukawa, Shuichi Nakamura

    2nd FRIMS International Symposium on Frontier Materials  (Nagoya Institute of Technology)  2018.02  -  2018.02  FRIMS

  • Direct catalytic enantioselective Mannich-type reaction of α,α-dithioacetonitriles with imines

    Hikari Saito, Masaru Kondo, Shuichi Nakamura

    2nd FRIMS International Symposium on Frontier Materials  (Nagoya Institute of Technology)  2018.02  -  2018.02  FRIMS

  • Direct catalytic enantioselective reaction of α,α-dithioacetonitriles using chiral bis(imidazoline)-Pd complexes

    Hikari Saito, Masaru Kondo, and Shuichi Nakamura

    第64回有機金属化学討論会  (東北大学川内キャンパス)  2017.09  -  2017.09 

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Academic Awards Received

  • Inoue Research Award for Young Scientists

    2002.04