YAMAMURA Hatsuo

写真a

Affiliation Department etc.

Department of Life Science and Applied Chemistry
Department of Life Science and Applied Chemistry

Title

Professor

Mail Address

E-mail address

Research Fields, Keywords

organic chemistry

Graduating School

  •  
    -
    1984.03

    Kyushu University   Faculty of Pharmaceutical Science   Graduated

Graduate School

  •  
    -
    1986.03

    Kyushu University  Graduate School, Division of Pharmaceutical Sciences  Master's Course  Completed

Degree

  • Nagasaki University -  Doctor (Pharmaceutical Scinece)

  • Kyushu University -  Master of Pharmaceutical Scinece

 

Research Career

  • Synthetic Studies of Carbohydrates and Analysis of Its Property

    Collaboration in Japan   (not selected)  

    Project Year:   - 

  • Chemistry of Natural and Modified Cyclodextrin

    International Collaboration   (not selected)  

    Project Year:   - 

Papers

  • Antibacterial Activity of Membrane-permeabilizing Bactericidal Cyclodextrin Derivatives

    Hatsuo Yamamura, Tatsuya Hagiwara, Yuma Hayashi, Kayo Osawa, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Ayumi Sumino, Hayato Yamashita, Ryo Jinno, Masayuki Abe, Atsushi Miyagawa

    ACS Omega     2021.11  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Antimicrobial activities of amphiphilic cationic polymers and their efficacy of combination with novobiocin

    Miyagawa, A., Ohno, S., Hattori, T., Yamamura, H

    Journal of Biomaterials Science, Polymer Edition     2021.10  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • N, N-Bis (hexyl α-d-acetylmannosyl) Acrylamide

    Atsushi Miyagawa, Shinya Ohno, Hatsuo Yamamura

    Molbank   2021 ( 3 ) M1255   2021.07  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • One-Step Synthesis of Sugar Nucleotides

    Atsushi Miyagawa, Sanami Toyama, Ippei Ohmura, Shun Miyazaki, Takeru Kamiya, Hatsuo Yamamura

    J. Org. Chem.   85   15645 - 15651   2020.11  [Refereed]

    Research paper (scientific journal)   Single Author

  • Synthesis of β-1,3-glucan mimics by β-1,3-glucan trisaccharyl monomer polymerization

    Atsushi Miyagawa, Hatsuo Yamamura

    Carbohydrate Polymers   227   115105   2020.01  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    β-1,3-Glucans are important as immunostimulating agents in living organisms. The multivalent binding ofβ-1,3glucans to dectin-1, a cell surface receptor, activates immunological defenses. To study artificial immunostimulating agents, glycopolymers carrying β-1,3-glucan trisaccharides as artificial ligands were synthesized. The β-1,3-glucan trisaccharide, defined as an active unit of β-1,3-glucan, was constructed from D-glucose by glycosylation. A norbornene group was introduced as a polymerizable group into the trisaccharide derivative at the aglycone. The prepared endo/exo norbornene stereoisomers of the monomers were separated by silica gel chromatography and identified by NMR spectroscopy and mass spectrometry. The synthesized glycosyl monomers were polymerized and copolymerized with norbornene using 2nd generation Hoveyda-Grubbs catalyst, deprotected, and purified by gel filtration to prepare water-soluble glycopolymers of varied compositions and high molecular weights. These polymers will have the potential for multivalent binding to dectin-1 to activate immune response and facilitate studies to understand the binding mechanisms of β-1,3-glucans with dectin-1.

  • Gramicidin S-inspired Antimicrobial Cyclodextrin to Disrupt Gram-negative and Gram-positive Bacterial Membranes

    Hatsuo Yamamura, Kana Isshiki, Yusuke Fujita, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Kayo Osawa, Atsushi Miyagawa

    MedChemComm   ( 10 ) 1432 - 1437   2019.08  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-O-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.

  • Development of New Antimicrobial Agents from Cationic PG-surfactants containing oligo-Lys peptides

    Kimura Ryosuke, Shibata Masahide, Koeda Shuhei, Miyagawa Atsushi, Yamamura Hatsuo Mizuno Toshihisa

    Bioconjugate Chemistry     2018.12  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

    Peptide gemini-surfactant (PG-surfactant), a kind of lipopeptide, is composed of a short linker peptide (X) between two alkyl-chain-modified Cys residues, and peripheral peptides at the N-terminal (Y) and the C-terminal (Z) sides, respectively, of the alkylated
    Cys residues. In this study, we developed and examined a series of PG-surfactants containing two C12 saturated alkanes and oligo-Lys, arranged at the X-, Y-, or Z-positions. To arrange oligo-Lys at the Y- or Z-positions, a repeat sequence of -Asp-Lys-Asp-Lys-
    was used at the X-position. All of the PG-surfactants exhibited high antimicrobial activity against both gram-positive and negative bacteria. In addition to high antimicrobial activity, a low hemolysis activity is prerequisite for efficient intravenous administration.
    Among the synthesized PG-surfactants, those having -(Lys)3- at the Y- or Z-positions, i.e. K3-DKDKC12 and DKDKC12-K3, showed reasonably low hemolytic activities. This combination of high antimicrobial activity along with low hemolytic activity is an
    essential and unique property, and has not been previously reported for the synthesized lipopeptides. Further, using scanning electron microscope (SEM) and N-phenyl-1-naphthylamine (NPN) uptake assay we showed that the antimicrobial activity of these PG-surfactants may be attributed to membrane disruptive mechanisms. Although the PG-surfactants with low hemolytic activity could interact and localize onto red blood cell surfaces, and cause slight expansion of cell morphologies, no subsequent penetration occurred. In summary, we describe here the successful development of PG-surfactants having high antibacterial and low hemolytic activity, thus providing a significant molecular platform to develop novel antimicrobial agents.

  • Transglycosylation Activity of Catalytic Domain Mutant of Endo-1,3-β-glucanase from Cellulosimicrobium Cellulans

    Y. Hantani, S. Motoki, A. Miyagawa, H. Yamamura, M.Oda

    Protein & Peptide Letters   25   1 - 5   2018.07  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Membrane-Active Antimicrobial Poly(Amino-Modified Alkyl) beta-Cyclodextrins Synthesized via Click Reactions

    Hatsuo Yamamura, Miho Nonaka, Shingo Okuno, Ryogo Mitsuhashi, Hisato Kato, Takashi Katsu, Kazufumi Masuda, Koichi Tanimoto,Haruyoshi Tomita, Atsushi Miyagawa

    MedChemComm   9   509 - 518   2018.03  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

  • Syntheses and structure–membrane active antimicrobial activity relationship of alkylamino-modified glucose, maltooligosaccharide, and amylose

    Hatsuo Yamamura, Takahiro Mabuchi, Tomoki Ishida, Atsushi Miyagawa

    Chemical Biology & Drug Design   90 ( 5 ) 1012 - 1018   2017.11  [Refereed]

    Research paper (scientific journal)   Multiple Authorship

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Review Papers

  • Chemical Modification of Cyclodextrin and Amylose by Click Reaction and Its Application to Synthesis of Poly-alkylamine-modified Antibacterial Sugars

    Hatsuo Yamamura

    Chem. Pharm. Bull.   65 ( 4 ) 312 - 317   2017.04  [Refereed]  [Invited]

    Introduction and explanation (scientific journal)   Single Author

Presentations

  • An antibacterial oligosaccharide makes lipid bilayer multi-layered

    Ayumi Sumino,Tatsuya Hagiwara, Hatsuo Yamamura

    第57回日本生物物理学会年会  2019.09  -  2019.09 

  • CYCLODEXTRIN DERIVATIVES BEING ANTIMICROBIAL THROUGH MULUPOINT INTERACTION WITH BACTERIAL MEMBRANE

    H. Yamamura  [Invited]

    The 4th Symposium on Weak Molecular Interactions  2019.05  -  2019.05 

  • A Raman microspectroscopic study on the destruction process of liposome membranes by hepta-6-benzylamino-β-cyclodextrin

    Tatsuyuki Yamamoto, Chikako Yoshimoto, Hiroki Tanaka, Hemanth Noothalapati, Keisuke Yoshikiyo, Atsushi Miyagawa, Hatsuo Yamamura

    The 19th International Cyclodextrin Symposium  2018.04  -  2018.04 

  • Studies on a β-cyclodextrin derivative induced destruction process of liposomal membrane by confocal Raman microspectroscopy

    Chikako Yoshimoto, Akiko Miyazako, Keita Iwaski, Hemanth Noothalapati, Atsushi Miyagawa, Hatsuo Yamamura, Tatsuyuki Yamamoto

    Japan-Taiwan Medical Spectroscopy International Symposium/14th Annual Meeting of the Japan Association of Medical Spectroscopy  2016.12  -  2016.12 

  • 蛍光基を有するシアリルガラクトース結合位置異性体の合成とその加水分解特異性評価

    栗本 健太、山村 初雄、宮川 淳

    第34回 日本糖質学会年会  2015.07  -  2015.07 

  • Antimicrobial Cyclodextrin Bearing Polyamino Groups for Bacterial Membrane Disruption

    Hatsuo Yamamura  [Invited]

    The 8th Asian Cyclodextrin Symposium  2015.05  -  2015.05 

  • Synthetic β-1,3-Oligoglucans as Probes to Study for Hydrolysis and Recognition of Endo-β-1,3-Glucanas

    A. Miyagawa、 M. Oda、H. Yamamura

    糖質科学学会-日本糖質学会合同シンポジウム  2014.11  -  2014.11 

  • Comprehensive syntheses of sialyl galactoside regioisomers

    Kenta Kurimoto、Hatsuo Yamamura、Atsushi Miyagawa

    糖質科学学会-日本糖質学会合同シンポジウム  2014.11  -  2014.11 

  • シクロデキストリンおよびアミロースのクリック反応による化学修飾

    村田健介,林孝暁,宮川淳,山村初雄

    第29回シクロデキストリンシンポジウム  2012.09  -  2012.09 

  • Synthesis of -(1,6)-Branched -(1,3)-Oligoglucans and Evaluation of Hydrolysis Activity of -(1,3)-Glucanase

    A. Miyagawa, Y. Tanabe,S. Motoki,M. Oda,H. Yamamura

    26th International Carbohydrate Symposium  2012.07  -  2012.07 

Industrial Property

  • Monoclonal antibody to human hemoglobin and its use for detection of occult blood

    特願 昭63―273472 

    Monoclonal antibody to human hemoglobin and its use for detection of occult blood

Academic Awards Received

  • Award for the Young Cyclodextrin Scientist, The Society of Cyclodextrins, Japan

    2001.04